DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17802 and ZNF547

DIOPT Version :9

Sequence 1:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_775902.2	Gene:	ZNF547 / 284306	HGNCID:	26432	Length:	402	Species:	Homo sapiens

Alignment Length:	295	Identity:	79/295 - (26%)
Similarity:	125/295 - (42%)	Gaps:	41/295 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 FEDIACEIPFSKED----DEQEQQQEYEDMVDK------KTGHDDGEESQEC-----------EE 188
            |||:|  |.||:|:    || .|:..|.|::.:      ..|...|.|.:|.           :.
Human    13 FEDVA--IYFSQEEWGHLDE-AQRLLYRDVMLENLALLSSLGCCHGAEDEEAPLEPGVSVGVSQV 74

  Fly   189 SQPDEEESQQNEEDEEESQEDDDELWQNEDGDSDTDADSMSDIEATSRQSALDEDKKPRRKYTKR 253
            ..|....|.||.:..|.......::.:..:.|.......:....|...|    ..|:..|:...|
Human    75 MAPKPCLSTQNTQPCETCSSLLKDILRLAEHDGTHPEQGLYTCPAHLHQ----HQKEQIREKLSR 135

  Fly   254 SSPKNDDTDFLKPA-KKKRKTYISQKVHICDHCGKKFTDKGNFNLHVLRHSGVKPFECPECGQKE 317
            .       |..:|. .|..:.:::.|..:|..|||.|:.|...:.|...|:|.:.::|.:||...
Human   136 G-------DGGRPTFVKNHRVHMAGKTFLCSECGKAFSHKHKLSDHQKIHTGERTYKCSKCGILF 193

  Fly   318 FNRYILNIHIRVKHRGEKPYACQFCDERFVHSTMRSRHENRVHRNKKTPKNFKCNYCDKRYESNY 382
            ..|..||.|.|. |.||:||.|..|.:.|:..:...||:. :|..::.   ::|:.|.|.:..:.
Human   194 MERSTLNRHQRT-HTGERPYECNECGKAFLCKSHLVRHQT-IHSGERP---YECSECGKLFMWSS 253

  Fly   383 QRAKHEVVHTGERNFHCEVCKVSFTRNSNLKTHYR 417
            ....|:.||||:|.:.|..|...|..||||..|||
Human   254 TLITHQRVHTGKRPYGCSECGKFFKCNSNLFRHYR 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		C2H2 Zn finger	310..331	CDD:275368	8/20 (40%)
		C2H2 Zn finger	339..360	CDD:275368	5/20 (25%)
		C2H2 Zn finger	371..388	CDD:275370	3/16 (19%)
		zf-met	398..421	CDD:289631	10/20 (50%)
		C2H2 Zn finger	399..417	CDD:275368	8/17 (47%)
ZNF547	NP_775902.2	KRAB	11..66	CDD:214630	17/55 (31%)
		KRAB	11..50	CDD:279668	13/39 (33%)
		COG5048	<156..314	CDD:227381	47/138 (34%)
		C2H2 Zn finger	158..178	CDD:275368	7/19 (37%)
		C2H2 Zn finger	186..206	CDD:275368	8/20 (40%)
		zf-H2C2_2	199..221	CDD:290200	11/22 (50%)
		C2H2 Zn finger	214..234	CDD:275368	5/20 (25%)
		zf-H2C2_2	226..249	CDD:290200	6/26 (23%)
		C2H2 Zn finger	242..262	CDD:275368	4/19 (21%)
		C2H2 Zn finger	270..290	CDD:275368	10/19 (53%)
		C2H2 Zn finger	298..318	CDD:275368
		zf-H2C2_2	311..334	CDD:290200
		C2H2 Zn finger	326..346	CDD:275368
		zf-H2C2_2	339..363	CDD:290200
		C2H2 Zn finger	354..374	CDD:275368
		C2H2 Zn finger	380..400	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050