DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17802 and ace2

DIOPT Version :9

Sequence 1:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_594109.1	Gene:	ace2 / 2541661	PomBaseID:	SPAC6G10.12c	Length:	533	Species:	Schizosaccharomyces pombe

Alignment Length:	522	Identity:	99/522 - (18%)
Similarity:	171/522 - (32%)	Gaps:	166/522 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 YTQNPVNIFDENSKMVRQIALVTGLWLTDHSKMPRNMCSCCLLSLKSAIAFRQACIKTNNRLTI- 76
            :.||..:.||.:|.:                |.|.|.    ||...||...       :|::::
pombe    67 HLQNFQDQFDYSSVL----------------KTPFNP----LLEANSAYFL-------SNQISLP 104

  Fly    77 QRRSVEAKDDGCWADP------LSDAHEGLKINDAEV-----EQEVLYEVSYADNEGLEE----- 125
            ...|..:..|...:.|      :|..|.....|:.:.     .|:...|:.|..:..::|
pombe   105 DSHSYASSFDASLSPPSSPLTCVSQIHTEQNFNNNDAFSLTNSQQAFSEIGYDASNWIDELDSQQ 169

  Fly   126 ------DHDLYKKEEEESEVNENKE----FEDIACEIPFSK--------EDDEQEQQQEYEDMVD 172
                  :.|:   .|.::|...||:    |:.::..||.:.        ...:.|...|:..:..
pombe   170 QVLSFPEFDI---PEIKTETCSNKDHLENFDYLSSSIPETSGPASSVLPSSSQLESFNEFMFLPS 231

  Fly   173 KKTGHDDGEESQECEE-----SQPDEEESQQNEEDEEESQEDDDELWQNEDGDSDTDADSMSDI- 231
            ...|.|:...:...||     |||.....                    .|..|...|.::|.:
pombe   232 SPPGLDEINGAPSFEELNFQISQPSPAHP--------------------VDLSSPETAPNISPVS 276

  Fly   232 --------EATSRQS---ALDED---------KKPRRKYTKRSSPKNDDTDFLKPAKKKRKTYIS 276
                    |.||.|.   |||..         ...::.:.|.|||....::|.|.:.
pombe   277 PFAQLVKLEPTSPQKPSFALDSSFSHLDVCRHTDNQKAFAKLSSPAEYVSEFEKFSS-------- 333

  Fly   277 QKVHICDHCGKKFTDKGNFNLHVLRHSGV-----------KPFECPECGQKE-----FNRYILNI 325
                :||| |...:: .|.|..:.:...:           ||..|....::|     .....|:|
pombe   334 ----VCDH-GLDISN-ANINNTLTQQFALSAPYESCIVTKKPEPCITVKEEEQLAPKIESADLSI 392

  Fly   326 HIRVKHRGEKP-------YAC-------QFCDERFVHSTMRSRHENRVHRNKKTPKNFKCNY--C 374
            ..:|.....||       :.|       :.|  |....||.|     ::...:....:.|.|  |
pombe   393 TPQVTEHDSKPPVRISYDHRCKTRKQSTRIC--RIPPETMAS-----LYCGPEADGKYVCLYNGC 450

  Fly   375 DKRYESNYQRAKHEVVHTGERNFHCEVCKVSFTRNSNLKTHYRSRQHQNKLIAMSAK--SEIDSK 437
            :||....|....|...|..:|.:.|::||..|.|:.:||.|.|..::....:....|  :.:|:.
pombe   451 NKRIARKYNVESHIQTHLSDRPYRCDLCKAGFVRHHDLKRHLRIHENGRPYVCECLKRFNRLDAL 515

  Fly   438 NK 439
            |:
pombe   516 NR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071	13/60 (22%)
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		C2H2 Zn finger	310..331	CDD:275368	5/25 (20%)
		C2H2 Zn finger	339..360	CDD:275368	6/27 (22%)
		C2H2 Zn finger	371..388	CDD:275370	6/18 (33%)
		zf-met	398..421	CDD:289631	9/22 (41%)
		C2H2 Zn finger	399..417	CDD:275368	8/17 (47%)
ace2	NP_594109.1	COG5048	45..518	CDD:227381	99/522 (19%)
		C2H2 Zn finger	448..467	CDD:275368	5/18 (28%)
		zf-C2H2	473..495	CDD:278523	9/21 (43%)
		C2H2 Zn finger	475..495	CDD:275368	9/19 (47%)
		zf-H2C2_2	487..511	CDD:290200	5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	84	1.000	Inparanoid score	I1804
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050