DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17802 and ZNF396

DIOPT Version :9

Sequence 1:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001309215.1	Gene:	ZNF396 / 252884	HGNCID:	18824	Length:	335	Species:	Homo sapiens

Alignment Length:	358	Identity:	83/358 - (23%)
Similarity:	135/358 - (37%)	Gaps:	78/358 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 KSAIAFRQACIKTNNRLTIQRRSVEAKDDGCWADPLSDAHEGLKINDAEVEQEVLYEVSYADNEG 122
            ||:....|...:.|..||   ..:|.::..|  ||.|..|.....:.....|: ..:..|.|:.|
Human     7 KSSSLLTQTSEECNGILT---EKMEEEEQTC--DPDSSLHWSSSYSPETFRQQ-FRQFGYQDSPG 65

  Fly   123 LEED--------H-----DLYKKEE---------------EESEVNENKEFEDIACEIPFSKEDD 159
            ..|.        |     :::.||:               :|.:....|...:...|.....||.
Human    66 PHEALSRLWELCHLWLRPEVHTKEQILELLVLEQFLAILPKELQAWVQKHHPENGEETVTMLEDV 130

  Fly   160 EQE---QQQEY----EDMVDKKTGHDDGEESQECEESQPDEEESQQNEEDEEESQEDDDELWQNE 217
            |:|   .:|.:    :||:.:|....:..|.....:..|.:::.|....:.:..:..|:::....
Human   131 ERELDGPKQIFFGRRKDMIAEKLAPSEITEELPSSQLMPVKKQLQGASWELQSLRPHDEDIKTTN 195

  Fly   218 DGDSDTDADS--------------MSDIEATSRQSALDEDKKPRRKYTKRSSPKNDDTDFLKPAK 268
            ...:.....|              |:..::::.:...::|    .::.||..         .|:.
Human   196 VKSASRQKTSLGIELHCNVSNILHMNGSQSSTYRGTYEQD----GRFEKRQG---------NPSW 247

  Fly   269 KKRKTYISQKVHICDHCGKKFTDKGNFNLHVLRHSGVKPFECPECGQKEFNRYILNIHIRVKHRG 333
            ||:     ||   ||.|||.|:......||...|||.||:.|.||. |.|:|..:.|..|..|.|
Human   248 KKQ-----QK---CDECGKIFSQSSALILHQRIHSGKKPYACDECA-KAFSRSAILIQHRRTHTG 303

  Fly   334 EKPYACQFCDERFVHSTMRSRHENRVHRNKKTP 366
            ||||.|..|.:.|..|:...||..| |..||.|
Human   304 EKPYKCHDCGKAFSQSSNLFRHRKR-HIRKKVP 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071	4/15 (27%)
		C2H2 Zn finger	282..302	CDD:275368	8/19 (42%)
		C2H2 Zn finger	310..331	CDD:275368	8/20 (40%)
		C2H2 Zn finger	339..360	CDD:275368	7/20 (35%)
		C2H2 Zn finger	371..388	CDD:275370
		zf-met	398..421	CDD:289631
		C2H2 Zn finger	399..417	CDD:275368
ZNF396	NP_001309215.1	SCAN	48..157	CDD:128708	19/109 (17%)
		SCAN	48..136	CDD:280241	15/88 (17%)
		COG5048	239..>306	CDD:227381	31/84 (37%)
		zf-C2H2	252..273	CDD:278523	9/23 (39%)
		C2H2 Zn finger	253..273	CDD:275368	8/19 (42%)
		zf-H2C2_2	269..290	CDD:290200	11/21 (52%)
		C2H2 Zn finger	281..301	CDD:275368	8/20 (40%)
		zf-H2C2_2	294..318	CDD:290200	11/23 (48%)
		C2H2 Zn finger	309..329	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050