DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17802 and ZSCAN25

DIOPT Version :9

Sequence 1:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001337908.1	Gene:	ZSCAN25 / 221785	HGNCID:	21961	Length:	544	Species:	Homo sapiens

Alignment Length:	372	Identity:	92/372 - (24%)
Similarity:	156/372 - (41%)	Gaps:	64/372 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 PLSDAHEGL-KINDAEVEQEVLYEVSYADNEGLEEDHDLYKKEEEESEV--------NENKEFED 147
            |:..|..|| .:|..:.|....:..:.:...|..:|..|...|||...|        .|..|.:|
Human   199 PVLQAGPGLPAVNPRDQEMAAGFFTAGSQGLGPFKDMALAFPEEEWRHVTPAQIDCFGEYVEPQD 263

  Fly   148 IACEIP---FSKEDDEQEQQQEYEDMVDKKTGHDDGEESQE-------CEE-------SQPDEEE 195
              |.:.   .|||.:.:..|::.:..:...|....||.|.:       ||:       |.|....
Human   264 --CRVSPGGGSKEKEAKPPQEDLKGALVALTSERFGEASLQGPGLGRVCEQEPGGPAGSAPGLPP 326

  Fly   196 SQQNEEDEEESQEDDDELWQ----NEDGDSDTDADSMSDIEATSRQSALDEDK-----KPRRKYT 251
            .|.......:..:.....|:    .|.|...:.:.::      .|.....|:|     :..:.:|
Human   327 PQHGAIPLPDEVKTHSSFWKPFQCPECGKGFSRSSNL------VRHQRTHEEKSYGCVECGKGFT 385

  Fly   252 KRSSPKNDDTDFLKPAKKKRKTYISQKVHICDHCGKKFTDKGNFNLHVLRHSGVKPFECPECGQK 316
            .|        ::|   .|.::|::.::.::|..|.|.|:.:.:..:|...|:|.||::|.:|.:.
Human   386 LR--------EYL---MKHQRTHLGKRPYVCSECWKTFSQRHHLEVHQRSHTGEKPYKCGDCWKS 439

  Fly   317 EFNRYILNIHIRVKHRGEKPYACQFCDERFVHSTMRSRHEN-RVHRNKKT-PKNFKCNYCDKRYE 379
            ...|..|.:|.|. |.|||||.|: |.:.|      ||:.| .|||...| .|.:.|..|.||:.
Human   440 FSRRQHLQVHRRT-HTGEKPYTCE-CGKSF------SRNANLAVHRRAHTGEKPYGCQVCGKRFS 496

  Fly   380 SNYQRAKHEVVHTGERNFHCEVCKVSFTRNSNLKTHYRSRQHQNKLI 426
            ...:..:|:.:||||:.:||..|..||.:.|.|..|.:::..|..|:
Human   497 KGERLVRHQRIHTGEKPYHCPACGRSFNQRSILNRHQKTQHRQEPLV 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071
		C2H2 Zn finger	282..302	CDD:275368	5/19 (26%)
		C2H2 Zn finger	310..331	CDD:275368	6/20 (30%)
		C2H2 Zn finger	339..360	CDD:275368	6/21 (29%)
		C2H2 Zn finger	371..388	CDD:275370	4/16 (25%)
		zf-met	398..421	CDD:289631	8/22 (36%)
		C2H2 Zn finger	399..417	CDD:275368	7/17 (41%)
ZSCAN25	NP_001337908.1	SCAN	38..136	CDD:322011
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..189
		KRAB_A-box	231..>259	CDD:143639	7/27 (26%)
		COG5048	<324..532	CDD:227381	60/232 (26%)
		C2H2 Zn finger	350..370	CDD:275368	3/25 (12%)
		C2H2 Zn finger	377..397	CDD:275368	4/30 (13%)
		C2H2 Zn finger	405..425	CDD:275368	5/19 (26%)
		C2H2 Zn finger	433..453	CDD:275368	6/20 (30%)
		C2H2 Zn finger	461..480	CDD:275368	9/25 (36%)
		C2H2 Zn finger	488..508	CDD:275368	5/19 (26%)
		C2H2 Zn finger	516..535	CDD:275368	7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960