DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17802 and ZNF169

DIOPT Version :9

Sequence 1:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_003439.2	Gene:	ZNF169 / 169841	HGNCID:	12957	Length:	604	Species:	Homo sapiens

Alignment Length:	353	Identity:	87/353 - (24%)
Similarity:	131/353 - (37%)	Gaps:	81/353 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 EGLEEDHDLYKKEEEE----SEVNENKEFEDIACEIPFSKEDDEQEQQQEY-------EDMVDKK 174
            |.||:..:.:::|.|.    .......||:.   ..|........:..::|       :......
Human    64 EQLEQGDEPWREENEHLLDLCPAEPRTEFQP---SFPHLVAFSSSQLLRQYALSGHPTQIFPSSS 125

  Fly   175 TGHDDGEESQECEESQPDEEESQQNEEDEEESQEDDDELWQNEDGDSDT-----DADSMSDIEAT 234
            .|.|...|:..|        .|::.|..|.|.  .|..|.:.....|.|     ..|.:..:|.
Human   126 AGGDFQLEAPRC--------SSEKGESGETEG--PDSSLRKRPSRISRTFFSPHQGDPVEWVEG- 179

  Fly   235 SRQSALDEDKKPRRKYTKRSSPKNDDTDFLKPA-----------------KKKRKTYISQKVHIC 282
            :|:...|      .:..:|.|....|| .||.|                 .||...:..||.|:|
Human   180 NREGGTD------LRLAQRMSLGGSDT-MLKGADTSESGAVIRGNYRLGLSKKSSLFSHQKHHVC 237

  Fly   283 DHCGKKFTDKGNFNLHVLRHSGVKPFECPECGQKEFNRYILNIHIRVKHRGEKPYACQFCDERFV 347
            ..||:.|..:.:...|...|:|.||:.|||||::...:..|:||.| ||.|||||.|:.|...|.
Human   238 PECGRGFCQRSDLIKHQRTHTGEKPYLCPECGRRFSQKASLSIHQR-KHSGEKPYVCRECGRHFR 301

  Fly   348 HSTMRSRHENRVH-------------------------RNKKTPKNFKCNYCDKRYESNYQRAKH 387
            :::..:.|: |:|                         |.....|.|.|..|.:.:.......:|
Human   302 YTSSLTNHK-RIHSGERPFVCQECGRGFRQKIALLLHQRTHLEEKPFVCPECGRGFCQKASLLQH 365

  Fly   388 EVVHTGERNFHCEVCKVSFTRNSNLKTH 415
            :..|||||.|.|..|..||.:.|.|.:|
Human   366 QSSHTGERPFLCLECGRSFRQQSLLLSH 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071
		C2H2 Zn finger	282..302	CDD:275368	5/19 (26%)
		C2H2 Zn finger	310..331	CDD:275368	9/20 (45%)
		C2H2 Zn finger	339..360	CDD:275368	5/20 (25%)
		C2H2 Zn finger	371..388	CDD:275370	2/16 (13%)
		zf-met	398..421	CDD:289631	7/18 (39%)
		C2H2 Zn finger	399..417	CDD:275368	7/17 (41%)
ZNF169	NP_003439.2	KRAB	14..73	CDD:214630	3/8 (38%)
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..182		14/70 (20%)
		COG5048	223..>584	CDD:227381	55/173 (32%)
		zf-C2H2	235..257	CDD:278523	6/21 (29%)
		C2H2 Zn finger	237..257	CDD:275368	5/19 (26%)
		zf-H2C2_2	249..274	CDD:290200	10/24 (42%)
		C2H2 Zn finger	265..285	CDD:275368	9/20 (45%)
		zf-H2C2_2	277..302	CDD:290200	14/25 (56%)
		C2H2 Zn finger	293..313	CDD:275368	5/20 (25%)
		zf-H2C2_2	305..330	CDD:290200	3/25 (12%)
		C2H2 Zn finger	321..341	CDD:275368	1/19 (5%)
		C2H2 Zn finger	349..369	CDD:275368	3/19 (16%)
		C2H2 Zn finger	377..397	CDD:275368	7/17 (41%)
		zf-C2H2	403..425	CDD:278523
		C2H2 Zn finger	405..425	CDD:275368
		zf-H2C2_2	418..442	CDD:290200
		C2H2 Zn finger	433..453	CDD:275368
		zf-H2C2_2	449..468	CDD:290200
		C2H2 Zn finger	461..481	CDD:275368
		zf-H2C2_2	474..496	CDD:290200
		C2H2 Zn finger	489..509	CDD:275368
		C2H2 Zn finger	518..537	CDD:275368
		C2H2 Zn finger	545..565	CDD:275368
		zf-H2C2_2	557..582	CDD:290200
		C2H2 Zn finger	573..592	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050