DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17802 and ZNF550

DIOPT Version :9

Sequence 1:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001264019.1	Gene:	ZNF550 / 162972	HGNCID:	28643	Length:	422	Species:	Homo sapiens

Alignment Length:	304	Identity:	81/304 - (26%)
Similarity:	122/304 - (40%)	Gaps:	72/304 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 DHDLYKKEEEES--EVNENKEFEDIACEIPFSKEDDEQEQQQEYEDMVDKKTGHDDGEESQECEE 188
            |..|.:..:||.  |:.:.|    :..|....||....:...|.|.:     |.|||..|:..:|
Human   120 DSRLGRARDEEGLLEMQKGK----VTPETDLHKETHLGKVSLEGEGL-----GTDDGLHSRALQE 175

  Fly   189 SQPDEEESQQNEEDEEESQEDDDELWQNEDGDSDTDADSMSDIEATSRQSALDEDKKPRRKYTKR 253
                                     |.:.|...:.|:      :...:.:.:.....|   |..:
Human   176 -------------------------WLSADVLHECDS------QQPGKDALIHAGTNP---YKCK 206

  Fly   254 SSPKNDDTDFLKPAKKKRKTYI--SQKVHI------CDHCGKKFTDKGNFNLHVLRHSGVKPFEC 310
            ...|..:          ||.|:  .|:||.      |:.|||.|:.......|.|.|:|.||::|
Human   207 QCGKGFN----------RKWYLVRHQRVHTGMKPYECNACGKAFSQSSTLIRHYLIHTGEKPYKC 261

  Fly   311 PECGQKEFNR--YILNIHIRVKHRGEKPYACQFCDERFVHSTMRSRHENRVHRNKKTPKNFKCNY 373
            .||| |.|.|  |::..|  ..|.|||||.|..|.:.|.|.:...|| ||.|..:|.   |:|..
Human   262 LECG-KAFKRRSYLMQHH--PIHTGEKPYECSQCRKAFTHRSTFIRH-NRTHTGEKP---FECKE 319

  Fly   374 CDKRYESNYQRAKHEVVHTGERNFHCEVCKVSFTRNSNLKTHYR 417
            |:|.:.:.....:|.::||||:.:.|..|..:|..:|.|..|.|
Human   320 CEKAFSNRAHLIQHYIIHTGEKPYDCMACGKAFRCSSELIQHQR 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		C2H2 Zn finger	310..331	CDD:275368	9/22 (41%)
		C2H2 Zn finger	339..360	CDD:275368	8/20 (40%)
		C2H2 Zn finger	371..388	CDD:275370	3/16 (19%)
		zf-met	398..421	CDD:289631	7/20 (35%)
		C2H2 Zn finger	399..417	CDD:275368	6/17 (35%)
ZNF550	NP_001264019.1	KRAB	12..72	CDD:214630
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..158		9/41 (22%)
		COG5048	<200..357	CDD:227381	57/176 (32%)
		C2H2 Zn finger	205..225	CDD:275368	5/29 (17%)
		C2H2 Zn finger	233..253	CDD:275368	7/19 (37%)
		C2H2 Zn finger	261..281	CDD:275368	9/22 (41%)
		C2H2 Zn finger	289..309	CDD:275368	8/20 (40%)
		C2H2 Zn finger	317..337	CDD:275368	4/19 (21%)
		C2H2 Zn finger	345..365	CDD:275368	7/19 (37%)
		zf-H2C2_2	357..382	CDD:404364	3/7 (43%)
		C2H2 Zn finger	373..393	CDD:275368
		zf-H2C2_2	385..410	CDD:404364
		C2H2 Zn finger	401..421	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050