DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17802 and ZNF565

DIOPT Version :9

Sequence 1:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001035939.1	Gene:	ZNF565 / 147929	HGNCID:	26726	Length:	499	Species:	Homo sapiens

Alignment Length:	371	Identity:	94/371 - (25%)
Similarity:	153/371 - (41%)	Gaps:	72/371 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 GCWADPLSDAHEGLKIND----AEVEQEVLYEVSYADNEGLEEDHDLYKKEEEESEVNENKEFED 147
            |.|...|....|.....|    .....|::..:..:|.||.:...|...:.:.|.:|||...|:.
Human    73 GPWCPDLESRCEKFLQKDIFEIGAFNWEIMESLKCSDLEGSDFRADWECEGQFERQVNEECYFKQ 137

  Fly   148 IAC---EIPFSKEDDEQEQQQEYEDMVDKKTGHDDGEESQECEE-----SQPDEEESQQNEEDEE 204
            :..   .:|..:.......:|..|          .||:..||.|     |:.......|.....|
Human   138 VNVTYGHMPVFQHHTSHTVRQSRE----------TGEKLMECHECGKAFSRGSHLIQHQKIHTGE 192

  Fly   205 ---------ESQEDDDELWQNE---DGDSDTDADSMSDIEATSRQSALDEDKKPRRKYTKRSSPK 257
                     ::......|.|::   .|:...|.....  :|..|.|.|   ...:|.:|.
Human   193 KPFGCKECGKAFSRASHLVQHQRIHTGEKPYDCKDCG--KAFGRTSEL---ILHQRLHTG----- 247

  Fly   258 NDDTDFLKPAKKK---------------RKTYISQKVHICDHCGKKFTDKGNFNLHVLRHSGVKP 307
                  :||.:.|               ::|:..:|.::|..|||.|.......:|...|:|.:|
Human   248 ------VKPYECKECGKTFRQHSQLILHQRTHTGEKPYVCKDCGKAFIRGSQLTVHRRIHTGARP 306

  Fly   308 FECPECGQKEFNRYI-LNIHIRVKHRGEKPYACQFCDERFVHSTMRSRHENRVHRNKKTPKNFKC 371
            :||.||| |.|.::. |.:|.|: |.|||||.|:.|.:.|:||:..:||: |:|..:|.   ::|
Human   307 YECKECG-KAFRQHSQLTVHQRI-HTGEKPYECKECGKGFIHSSEVTRHQ-RIHSGEKP---YEC 365

  Fly   372 NYCDKRYESNYQRAKHEVVHTGERNFHCEVCKVSFTRNSNLKTHYR 417
            ..|.|.:..:.|..:|:.||||:|.:.|:.|..:|:|:|.|..|.|
Human   366 KECGKAFRQHAQLTRHQRVHTGDRPYECKDCGKAFSRSSYLIQHQR 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071
		C2H2 Zn finger	282..302	CDD:275368	6/19 (32%)
		C2H2 Zn finger	310..331	CDD:275368	9/21 (43%)
		C2H2 Zn finger	339..360	CDD:275368	8/20 (40%)
		C2H2 Zn finger	371..388	CDD:275370	4/16 (25%)
		zf-met	398..421	CDD:289631	8/20 (40%)
		C2H2 Zn finger	399..417	CDD:275368	7/17 (41%)
ZNF565	NP_001035939.1	KRAB	6..66	CDD:214630
		C2H2 Zn finger	169..189	CDD:275368	4/19 (21%)
		COG5048	193..498	CDD:227381	68/241 (28%)
		C2H2 Zn finger	197..217	CDD:275368	2/19 (11%)
		C2H2 Zn finger	225..245	CDD:275368	5/24 (21%)
		C2H2 Zn finger	253..273	CDD:275368	1/19 (5%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
		C2H2 Zn finger	309..329	CDD:275368	9/21 (43%)
		C2H2 Zn finger	337..357	CDD:275368	8/20 (40%)
		C2H2 Zn finger	365..385	CDD:275368	5/19 (26%)
		C2H2 Zn finger	393..413	CDD:275368	8/19 (42%)
		C2H2 Zn finger	421..441	CDD:275368
		C2H2 Zn finger	449..469	CDD:275368
		C2H2 Zn finger	477..497	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960