DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17802 and ZNF274

DIOPT Version :9

Sequence 1:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_598009.1	Gene:	ZNF274 / 10782	HGNCID:	13068	Length:	653	Species:	Homo sapiens

Alignment Length:	486	Identity:	115/486 - (23%)
Similarity:	192/486 - (39%)	Gaps:	129/486 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IYTQNPVNIFDENSKMVRQIALVTGL-WLTDHSKMPRNM----CSCCLLSLKSAIAFRQACIKTN 71
            :.:|:|     ||.:.|  :|||.|: |:::...:|...    .:|||
Human   221 VESQHP-----ENCQEV--VALVEGVTWMSEEEVLPAGQPAEGTTCCL----------------- 261

  Fly    72 NRLTIQRRSVEAKDDGCWADPLSDAHEGLKINDAEVE-----------------QEVLYEV---- 115
             .:|.|:.  |.::|...........|.:...|..|:                 ::|:.|.
Human   262 -EVTAQQE--EKQEDAAICPVTVLPEEPVTFQDVAVDFSREEWGLLGPTQRTEYRDVMLETFGHL 323

  Fly   116 ------SYADNEGLEEDHDLYKKEEEES-EVNENKEFEDIACEIPFSKEDDEQEQQQEYEDMVDK 173
                  :..:|:.|..:.|:.::|...| :|.|:..    .|.:..:.||..|...||.:|.|.|
Human   324 VSVGWETTLENKELAPNSDIPEEEPAPSLKVQESSR----DCALSSTLEDTLQGGVQEVQDTVLK 384

  Fly   174 KTGHDDGEESQECEESQPDEEESQQNEEDEEESQEDDDELWQNEDGDSDTDADSMSDI---EATS 235
            :.            ||..:::..|:...|..|||.:        .|..||:..|:..|   |:.:
Human   385 QM------------ESAQEKDLPQKKHFDNRESQAN--------SGALDTNQVSLQKIDNPESQA 429

  Fly   236 RQSALDEDK------KPRRKYTKRSS--------------PKNDDTDFLKPAKKKRKTYISQKVH 280
            ...|||.::      .||::..||.|              .|:.:....|.....|||:......
Human   430 NSGALDTNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKAKEGNGCRKTFSRSTKQ 494

  Fly   281 I-------------CDHCGKKFTDKGNFNLHVLRHSGVKPFECPECGQKEFNRYILNIHIRVKHR 332
            |             |..|||.|.:...|::|...|:|.:|:.|.:||:.......|..|.|| |.
Human   495 ITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKGFVQSSSLTQHQRV-HS 558

  Fly   333 GEKPYACQFCDERFVHSTMRSRHENRVHRNKKTPKNFKCNYCDKRYESNYQRAKHEVVHTGERNF 397
            ||:|:.||.|...|...:..|:| .|.|...|.   :||..|.|.:..:....:|:..|||||.:
Human   559 GERPFECQECGRTFNDRSAISQH-LRTHTGAKP---YKCQDCGKAFRQSSHLIRHQRTHTGERPY 619

  Fly   398 HCEVCKVSFTRNSNL----KTHYRSRQHQNK 424
            .|..|..:||::|:|    :||.|:::.:.:
Human   620 ACNKCGKAFTQSSHLIGHQRTHNRTKRKKKQ 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071	14/66 (21%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		C2H2 Zn finger	310..331	CDD:275368	7/20 (35%)
		C2H2 Zn finger	339..360	CDD:275368	7/20 (35%)
		C2H2 Zn finger	371..388	CDD:275370	3/16 (19%)
		zf-met	398..421	CDD:289631	9/26 (35%)
		C2H2 Zn finger	399..417	CDD:275368	8/21 (38%)
ZNF274	NP_598009.1	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..159
		SCAN	157..269	CDD:128708	16/74 (22%)
		SCAN	157..245	CDD:280241	10/30 (33%)
		KRAB	287..>327	CDD:214630	4/39 (10%)
		KRAB	287..326	CDD:279668	4/38 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..359		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..414		7/33 (21%)
		COG5048	<389..644	CDD:227381	73/267 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..485		5/36 (14%)
		C2H2 Zn finger	481..501	CDD:275368	4/19 (21%)
		C2H2 Zn finger	509..529	CDD:275368	7/19 (37%)
		zf-H2C2_2	521..546	CDD:290200	8/24 (33%)
		C2H2 Zn finger	537..557	CDD:275368	7/20 (35%)
		zf-H2C2_2	549..573	CDD:290200	11/24 (46%)
		zf-C2H2	563..585	CDD:278523	7/22 (32%)
		C2H2 Zn finger	565..585	CDD:275368	7/20 (35%)
		zf-C2H2	591..613	CDD:278523	5/21 (24%)
		C2H2 Zn finger	593..613	CDD:275368	4/19 (21%)
		zf-H2C2_2	605..630	CDD:290200	9/24 (38%)
		C2H2 Zn finger	621..641	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	632..653		5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960