DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17802 and ZNF263

DIOPT Version :9

Sequence 1:	NP_650659.2	Gene:	CG17802 / 42143	FlyBaseID:	FBgn0038549	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_005732.2	Gene:	ZNF263 / 10127	HGNCID:	13056	Length:	683	Species:	Homo sapiens

Alignment Length:	542	Identity:	108/542 - (19%)
Similarity:	169/542 - (31%)	Gaps:	222/542 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 PLSDAHE--GLKINDAEVE-------QEVLYEVSYADNEGLEE-------------DHDLYKKEE 134
            ||..|.|  ..|:...|.|       ||:|......|.:.::|             :.::..||.
Human   146 PLETARESPSFKLEPMETERSPGPRLQELLGPSPQRDPQAVKERALSAPWLSLFPPEGNMEDKEM 210

  Fly   135 EESEVNENKEFEDIACEI---------PFSKEDDEQEQQQEYEDMVDKKTGHDDGEE-------- 182
            ...::.|:  .||:|..|         |..:.......|:.||: ||....|...:|
Human   211 TGPQLPES--LEDVAMYISQEEWGHQDPSKRALSRDTVQESYEN-VDSLESHIPSQEVPGTQVGQ 272

  Fly   183 --------SQECEES------QPDEEESQQNEEDEEESQED-------DDEL-----WQNEDG-- 219
                    .|.|:|.      .|.||:.:..|.......|:       .|:.     |..|.|
Human   273 GGKLWDPSVQSCKEGLSPRGPAPGEEKFENLEGVPSVCSENIHPQVLLPDQARGEVPWSPELGRP 337

  Fly   220 ----DSDTDADSMSDIE------ATSRQSALDEDKKPRRKYTKRSSPKN---------------- 258
                ..|........:|      ::.|:....::.:|::.:......||
Human   338 HDRSQGDWAPPPEGGMEQALAGASSGRELGRPKELQPKKLHLCPLCGKNFSNNSNLIRHQRIHAA 402

  Fly   259 -------DDTDF----------------------LKPAK---------KKRKTYISQKVHICDHC 285
                   |.|:.                      |:..|         :.::|:..:|.:.|:.|
Human   403 ERLCMGVDCTEIFGGNPRFLSLHRAHLGEEAHKCLECGKCFSQNTHLTRHQRTHTGEKPYQCNIC 467

  Fly   286 GKKFTDKGNFNLHVLRHSGVKPFECPECGQ---------------------------KEFNRYI- 322
            ||.|:...|.:.|...|:|.||::|||||:                           |.|:|..
Human   468 GKCFSCNSNLHRHQRTHTGEKPYKCPECGEIFAHSSNLLRHQRIHTGERPYKCPECGKSFSRSSH 532

  Fly   323 LNIHIRV--------------------------------------------------------KH 331
            |.||.|.                                                        .|
Human   533 LVIHERTHERERLYPFSECGEAVSDSTPFLTNHGAHKAEKKLFECLTCGKSFRQGMHLTRHQRTH 597

  Fly   332 RGEKPYACQFCDERFVHSTMRSRHENRVHRNKKTPKNFKCNYCDKRYESNYQRAKHEVVHTGERN 396
            .|||||.|..|.|.|.|.:...||: |:|..:|.   :.|:.|...:..:..|.:|...|||||.
Human   598 TGEKPYKCTLCGENFSHRSNLIRHQ-RIHTGEKP---YTCHECGDSFSHSSNRIRHLRTHTGERP 658

  Fly   397 FHCEVCKVSFTRNSNLKTHYRS 418
            :.|..|..||:|:|.|.:|.|:
Human   659 YKCSECGESFSRSSRLMSHQRT 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17802	NP_650659.2	zf-AD	4..74	CDD:285071
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		C2H2 Zn finger	310..331	CDD:275368	12/104 (12%)
		C2H2 Zn finger	339..360	CDD:275368	8/20 (40%)
		C2H2 Zn finger	371..388	CDD:275370	3/16 (19%)
		zf-met	398..421	CDD:289631	9/21 (43%)
		C2H2 Zn finger	399..417	CDD:275368	8/17 (47%)
ZNF263	NP_005732.2	SCAN	38..149	CDD:128708	2/2 (100%)
		Dendrin	<128..>347	CDD:317849	40/203 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..185		10/37 (27%)
		KRAB	218..277	CDD:214630	12/61 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..301		14/71 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..368		7/45 (16%)
		C2H2 Zn finger	380..400	CDD:275368	2/19 (11%)
		zf-C2H2	380..400	CDD:306579	2/19 (11%)
		COG5048	<434..649	CDD:227381	46/218 (21%)
		C2H2 Zn finger	436..456	CDD:275368	2/19 (11%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	577..597	CDD:275368	0/19 (0%)
		C2H2 Zn finger	605..625	CDD:275368	8/20 (40%)
		COG5048	629..>682	CDD:227381	19/55 (35%)
		C2H2 Zn finger	633..653	CDD:275368	4/19 (21%)
		C2H2 Zn finger	661..681	CDD:275368	9/20 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050