DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17806 and ZNF101

DIOPT Version :9

Sequence 1:	NP_650658.1	Gene:	CG17806 / 42142	FlyBaseID:	FBgn0038548	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_149981.2	Gene:	ZNF101 / 94039	HGNCID:	12881	Length:	436	Species:	Homo sapiens

Alignment Length:	416	Identity:	103/416 - (24%)
Similarity:	166/416 - (39%)	Gaps:	93/416 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RTCGQEAEHAKSLFDKEARDVLSNI--LKLTGFWLRNQPGVPTRICLSC-LLDLNDAIAFRERCI 67
            |.||::.       ..|.|:..|.|  ..|.   .::|.||....|..| .:.|..  :|.:|.:
Human    69 RLCGRKE-------GNEHRETFSQIPDCHLN---KKSQTGVKPCKCSVCGKVFLRH--SFLDRHM 121

  Fly    68 RTNSSWFEKQGKQEDSDTETAREGGNNRLESRVDVMPISIAQPQRRRILPQRSKKVDGVPLKTVE 132
            |.::.  .|:.:......||.|:   .:...:..:.|.|.|   ||.:.|.|.:
Human   122 RAHAG--HKRSECGGEWRETPRK---QKQHGKASISPSSGA---RRTVTPTRKR----------- 167

  Fly   133 TPIYPLVVPEIPPADLVDPLRCEDPIQVKSEPQLSSDYPVESMNHEEPASEMPQVMKEEPRTLQV 197
                              |..|:...:..:.|.|   :.:....|   ..:.....:|..|...|
Human   168 ------------------PYECKVCGKAFNSPNL---FQIHQRTH---TGKRSYKCREIVRAFTV 208

  Fly   198 I------GEVQKNRRKPRSKGCLEECPGK--DMAKIENIDSTTNKTKEEKYATRNKWGAA----- 249
            .      |::....::...|.|     ||  |...:..|...|: |.|:.|..: :.|.|
Human   209 SSFFRKHGKMHTGEKRYECKYC-----GKPIDYPSLFQIHVRTH-TGEKPYKCK-QCGKAFISAG 266

  Fly   250 ------KRAYALEHRLYFCDQCGKTFSEKGNFNVHLRRHKGTKEFQCQECDRMEFTQHLLNLHVR 308
                  .|::||| :.:.|.:|||..|...:.:.|.|.|.|.|.::||:|.::......|..|.|
Human   267 YLRTHEIRSHALE-KSHQCQECGKKLSCSSSLHRHERTHSGGKLYECQKCAKVFRCPTSLQAHER 330

  Fly   309 IKHRGELPYVCKYCGKRFD--NCLKRLNHERNHKESPVHRPHVCSTCQKAFKTSTALKDHIVVHT 371
             .|.||.||.|..|||.|:  :|.:|  |::.|..   .:|:.|:.|.|||...::|:.|.:.||
Human   331 -AHTGERPYECNKCGKTFNYPSCFRR--HKKTHSG---EKPYECTRCGKAFGWCSSLRRHEMTHT 389

  Fly   372 GEQPFHCELCQTFFNRRNALATHYKS 397
            ||:||.|:.|...|...|.|..|.::
Human   390 GEKPFDCKQCGKVFTFSNYLRLHERT 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17806	NP_650658.1	zf-AD	4..76	CDD:285071	17/72 (24%)
		zf-C2H2	260..282	CDD:278523	7/21 (33%)
		C2H2 Zn finger	262..282	CDD:275368	7/19 (37%)
		C2H2 Zn finger	290..311	CDD:275368	6/20 (30%)
		COG5048	<298..>383	CDD:227381	33/86 (38%)
		C2H2 Zn finger	319..339	CDD:275368	8/21 (38%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		ZnF_U1	375..407	CDD:197732	8/23 (35%)
		C2H2 Zn finger	378..396	CDD:275368	6/17 (35%)
ZNF101	NP_149981.2	KRAB	4..>46	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	104..124	CDD:275368	6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	128..164		9/41 (22%)
		lambda-1	149..>209	CDD:212564	14/97 (14%)
		C2H2 Zn finger	171..191	CDD:275368	3/22 (14%)
		COG5048	<176..357	CDD:227381	51/197 (26%)
		C2H2 Zn finger	199..219	CDD:275368	4/19 (21%)
		C2H2 Zn finger	227..247	CDD:275368	6/24 (25%)
		zf-H2C2_2	240..264	CDD:290200	7/25 (28%)
		C2H2 Zn finger	255..276	CDD:275368	3/21 (14%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		C2H2 Zn finger	312..332	CDD:275368	6/20 (30%)
		zf-H2C2_2	324..349	CDD:290200	13/25 (52%)
		COG5048	336..>407	CDD:227381	28/75 (37%)
		C2H2 Zn finger	340..360	CDD:275368	8/21 (38%)
		zf-H2C2_2	353..375	CDD:290200	7/26 (27%)
		C2H2 Zn finger	368..388	CDD:275368	7/19 (37%)
		zf-H2C2_2	380..404	CDD:290200	10/23 (43%)
		C2H2 Zn finger	396..416	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050