DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17806 and ZNF566

DIOPT Version :9

Sequence 1:	NP_650658.1	Gene:	CG17806 / 42142	FlyBaseID:	FBgn0038548	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001138815.1	Gene:	ZNF566 / 84924	HGNCID:	25919	Length:	419	Species:	Homo sapiens

Alignment Length:	434	Identity:	110/434 - (25%)
Similarity:	172/434 - (39%)	Gaps:	121/434 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RDVL----SNILKLTGFWLRNQPGVPTRICLSCLLDLNDAIAFRERCIRTNSSWFEKQGKQE-DS 83
            |||:    ||::.:.|..: ::|.|               |::.|            |||:. .:
Human    32 RDVMLENYSNLVSMAGHSI-SKPNV---------------ISYLE------------QGKEPWLA 68

  Fly    84 DTETAREGGNNRLESRVDVMPISIAQPQRRRILPQRSKKVDGVPLKTVETPIYPLVVPEIPPADL 148
            |.|..| |....||||.:.         ::..|.:...:::....:.:|    .|...:...:..
Human    69 DRELTR-GQWPVLESRCET---------KKLFLKKEIYEIESTQWEIME----KLTRRDFQCSSF 119

  Fly   149 VDPLRCEDPIQVKSE--------PQL---SSDYPVESMNHEEPASEMPQVM---------KEEPR 193
            .|...|..  |.|.|        .||   ..|.|  :::| .|:..:.|::         ||..:
Human   120 RDDWECNR--QFKKELGSQGGHFNQLVFTHEDLP--TLSH-HPSFTLQQIINSKKKFCASKEYRK 179

  Fly   194 TLQ-----VIGEVQKNRRKPRSKGCLEECPGKDMAKIENIDSTTNKTKEEKYATRNKWGAAKRA- 252
            |.:     ...|:.....||..  | :|| ||.......:      |..:|..|..|....|..
Human   180 TFRHGSQFATHEIIHTIEKPYE--C-KEC-GKSFRHPSRL------THHQKIHTGKKPFECKECG 234

  Fly   253 --------YALEHRL------YFCDQCGKTFSEKGNFNVHLRRHKGTKEFQCQECDR-----MEF 298
                    ....||:      |.|.:|||.||...||..|.|.|.|.|.::|:||.:     ..|
Human   235 KTFICGSDLTRHHRIHTGEKPYECKECGKAFSSGSNFTRHQRIHTGEKPYECKECGKAFSSGSNF 299

  Fly   299 TQHLLNLHVRIKHRGELPYVCKYCGKRFDNCLKRLNHERNHKESPVHRPHVCSTCQKAFKTSTAL 363
            ||     |.|| |.||.||.||.||..|....:.:.|:|.|..   .:|:.|..|:|||::.:.|
Human   300 TQ-----HQRI-HTGEKPYECKECGNAFSQSSQLIKHQRIHTG---EKPYECKECEKAFRSGSDL 355

  Fly   364 KDHIVVHTGEQPFHCELCQTFFNRRNALATHYKSKHHRLKVEEQ 407
            ..|..:||||:|:.|::|...:::.:.|.:     |||:...|:
Human   356 TRHQRIHTGEKPYECKICGKAYSQSSQLIS-----HHRIHTSEK 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17806	NP_650658.1	zf-AD	4..76	CDD:285071	10/55 (18%)
		zf-C2H2	260..282	CDD:278523	11/21 (52%)
		C2H2 Zn finger	262..282	CDD:275368	10/19 (53%)
		C2H2 Zn finger	290..311	CDD:275368	9/25 (36%)
		COG5048	<298..>383	CDD:227381	34/84 (40%)
		C2H2 Zn finger	319..339	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		ZnF_U1	375..407	CDD:197732	7/31 (23%)
		C2H2 Zn finger	378..396	CDD:275368	3/17 (18%)
ZNF566	NP_001138815.1	KRAB	6..66	CDD:214630	13/61 (21%)
		KRAB	6..45	CDD:279668	5/12 (42%)
		COG5048	<154..330	CDD:227381	54/192 (28%)
		zf-C2H2	200..222	CDD:278523	7/31 (23%)
		C2H2 Zn finger	202..222	CDD:275368	7/27 (26%)
		zf-H2C2_2	215..237	CDD:290200	5/27 (19%)
		C2H2 Zn finger	230..250	CDD:275368	3/19 (16%)
		zf-H2C2_2	242..267	CDD:290200	8/24 (33%)
		COG5048	<254..405	CDD:227381	56/155 (36%)
		C2H2 Zn finger	258..278	CDD:275368	10/19 (53%)
		zf-H2C2_2	270..295	CDD:290200	10/24 (42%)
		C2H2 Zn finger	286..306	CDD:275368	9/25 (36%)
		zf-H2C2_2	298..323	CDD:290200	16/30 (53%)
		C2H2 Zn finger	314..334	CDD:275368	7/19 (37%)
		zf-H2C2_2	327..351	CDD:290200	9/26 (35%)
		C2H2 Zn finger	342..362	CDD:275368	7/19 (37%)
		zf-H2C2_2	354..379	CDD:290200	9/24 (38%)
		C2H2 Zn finger	370..390	CDD:275368	6/24 (25%)
		C2H2 Zn finger	398..417	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050