DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17806 and ZNF397

DIOPT Version :9

Sequence 1:	NP_650658.1	Gene:	CG17806 / 42142	FlyBaseID:	FBgn0038548	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	XP_006722621.1	Gene:	ZNF397 / 84307	HGNCID:	18818	Length:	553	Species:	Homo sapiens

Alignment Length:	484	Identity:	117/484 - (24%)
Similarity:	178/484 - (36%)	Gaps:	139/484 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RDVLSNILKLTGFWLRNQPGVPTRICLSCLLDLNDAIAFRERCIRTNSSWFEKQGKQEDSDTETA 88
            |:.||.:.:|...||  .|.:.|:..:..||.|...::.....::.   |.::...:...:..|.
Human    65 REALSRLQELCYQWL--MPELHTKEQILELLVLEQFLSILPEELQI---WVQQHNPESGEEAVTL 124

  Fly    89 REGGNNRLESRVDVMPISIAQPQRRRILPQRSKKVDGV-PLKTVETPIYPLVVPEIPPADL---- 148
            .|.    ||...|        ...:::..::|....|: .|:.|..|..| ..|.:|..||
Human   125 LED----LEREFD--------DPGQQVGTEKSDVGKGIYSLEHVMVPASP-QGPAVPWKDLTCLR 176

  Fly   149 ---------VDPLRCEDPIQVKS-EPQLSSDYPVESMNHEEPAS------EMPQVMKEEPRTLQV 197
                     :.||:    .|:|| :|.||   |.....:.|.|:      |..|.:.:|| :.:.
Human   177 ASQESTDIHLQPLK----TQLKSWKPCLS---PKSDCENSETATKEGISEEKSQGLPQEP-SFRG 233

  Fly   198 IGEVQKN------------RRKPRSKGCLEEC--PGKDMAKIENIDS-------TTNK------- 234
            |.|.:.|            .|.|...|...:.  ..|.:.|.:..|.       ||:.
Human   234 ISEHESNLVWKQGSATGEKLRSPSQGGSFSQVIFTNKSLGKRDLYDEAERCLILTTDSIMCQKVP 298

  Fly   235 ----------------------------TKEEKYATRNKWGAA--KRAYALEH-------RLYFC 262
                                        |.|:.|.. |:.|.|  .|:|.:.|       :.|.|
Human   299 PEERPYRCDVCGHSFKQHSSLTQHQRIHTGEKPYKC-NQCGKAFSLRSYLIIHQRIHSGEKAYEC 362

  Fly   263 DQCGKTFSEKGNFNVHLRRHKGTKEFQCQECDRMEFTQHLLNLHVRIKHRGELPYVCKYCGKRFD 327
            .:|||.|::......|.:.|.|.|..:|.||.:.......|.:|.|| |.||.||.|..|||.|.
Human   363 SECGKAFNQSSALIRHRKIHTGEKACKCNECGKAFSQSSYLIIHQRI-HTGEKPYECNECGKTFS 426

  Fly   328 NCLKRLNHERNHK-ESP---------------------VH---RPHVCSTCQKAFKTSTALKDHI 367
            ...|.:.|:|.|. |.|                     :|   :|:.||.|.|||..|:.|..|.
Human   427 QSSKLIRHQRIHTGERPYECNECGKAFRQSSELITHQRIHSGEKPYECSECGKAFSLSSNLIRHQ 491

  Fly   368 VVHTGEQPFHCELCQTFFNRRNALATHYK 396
            .:|:||:|:.|..|...|.|.:||..|.:
Human   492 RIHSGEEPYQCNECGKTFKRSSALVQHQR 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17806	NP_650658.1	zf-AD	4..76	CDD:285071	12/51 (24%)
		zf-C2H2	260..282	CDD:278523	7/21 (33%)
		C2H2 Zn finger	262..282	CDD:275368	6/19 (32%)
		C2H2 Zn finger	290..311	CDD:275368	7/20 (35%)
		COG5048	<298..>383	CDD:227381	37/109 (34%)
		C2H2 Zn finger	319..339	CDD:275368	8/19 (42%)
		C2H2 Zn finger	350..370	CDD:275368	9/19 (47%)
		ZnF_U1	375..407	CDD:197732	8/22 (36%)
		C2H2 Zn finger	378..396	CDD:275368	7/17 (41%)
ZNF397	XP_006722621.1	SCAN	46..139	CDD:128708	17/90 (19%)
		SCAN	46..134	CDD:280241	17/85 (20%)
		COG5048	<297..546	CDD:227381	64/226 (28%)
		zf-C2H2	304..326	CDD:278523	0/21 (0%)
		C2H2 Zn finger	306..326	CDD:275368	0/19 (0%)
		zf-H2C2_2	318..342	CDD:290200	6/24 (25%)
		C2H2 Zn finger	334..354	CDD:275368	6/20 (30%)
		zf-H2C2_2	346..371	CDD:290200	8/24 (33%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		zf-H2C2_2	374..399	CDD:290200	7/24 (29%)
		C2H2 Zn finger	390..410	CDD:275368	7/20 (35%)
		zf-H2C2_2	402..427	CDD:290200	14/25 (56%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		zf-H2C2_2	431..455	CDD:290200	5/23 (22%)
		C2H2 Zn finger	446..466	CDD:275368	0/19 (0%)
		zf-H2C2_2	458..482	CDD:290200	7/23 (30%)
		C2H2 Zn finger	474..494	CDD:275368	9/19 (47%)
		zf-H2C2_2	486..511	CDD:290200	9/24 (38%)
		C2H2 Zn finger	502..522	CDD:275368	7/19 (37%)
		zf-C2H2	528..550	CDD:278523
		C2H2 Zn finger	530..550	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960