DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17806 and ZNF557

DIOPT Version :9

Sequence 1:	NP_650658.1	Gene:	CG17806 / 42142	FlyBaseID:	FBgn0038548	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001037852.1	Gene:	ZNF557 / 79230	HGNCID:	28632	Length:	430	Species:	Homo sapiens

Alignment Length:	386	Identity:	102/386 - (26%)
Similarity:	154/386 - (39%)	Gaps:	80/386 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 EARDVLSNILKLTGFWLRNQPGVPTRICLSCLLDLND-AIAFRERCIRTNSSWFEKQGKQEDSDT 85
            |..::::.:||   .||:.            |:...| |:.|      |...|......|.....
Human    26 EGGELVNELLK---SWLKG------------LVTFEDVAVEF------TQEEWALLDPAQRTLYR 69

  Fly    86 ETAREGGNN--RLESRVDVMPISIAQPQRRRILPQRSKKVDGVPLKTVETPIYPLVVPEIPPADL 148
            :...|...|  .|.::|| .|..|:|      |.|..|      :.|.|..|.....|::
Human    70 DVMLENCRNLASLGNQVD-KPRLISQ------LEQEDK------VMTEERGILSGTCPDV----- 116

  Fly   149 VDPLRCEDPIQVKS-EPQLSSDYPVESMNHEEPASEMPQVMKEEPRTLQVI---GEVQKNRR--- 206
                  |:|.:.|. .|:|......:|.|.:...:.:...:.|..:..:|.   ..:.::|:
Human   117 ------ENPFKAKGLTPKLHVFRKEQSRNMKMERNHLGATLNECNQCFKVFSTKSSLTRHRKIHT 175

  Fly   207 KPRSKGCLEECPGKDMAKIENIDSTTNKTKEEKYATRNKWGAAKRAYALEHRLYFCDQCGKTFSE 271
            ..|..|| .|| ||                  .|::|:.....||.:..| :.|.|:.||||||.
Human   176 GERPYGC-SEC-GK------------------SYSSRSYLAVHKRIHNGE-KPYECNDCGKTFSS 219

  Fly   272 KGNFNVHLRRHKGTKEFQCQECDRMEFTQHLLNLHVRIKHRGELPYVCKYCGKRFDNCLKRLNHE 336
            :....||.|.|.|.|.::|.:|.:.......|..|:|| |.||.||.|..|.:.|........|:
Human   220 RSYLTVHKRIHNGEKPYECSDCGKTFSNSSYLRPHLRI-HTGEKPYKCNQCFREFRTQSIFTRHK 283

  Fly   337 RNHKESPVHRPHVCSTCQKAFKTSTALKDHIVVHTGEQPFHCELCQTFFNRRNALATHYKS 397
            |.| ....|  :||:.|.|||.|.::|..|..:||||.|:.|..|...|.||:.|..|.::
Human   284 RVH-TGEGH--YVCNQCGKAFGTRSSLSSHYSIHTGEYPYECHDCGRTFRRRSNLTQHIRT 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17806	NP_650658.1	zf-AD	4..76	CDD:285071	11/54 (20%)
		zf-C2H2	260..282	CDD:278523	11/21 (52%)
		C2H2 Zn finger	262..282	CDD:275368	10/19 (53%)
		C2H2 Zn finger	290..311	CDD:275368	6/20 (30%)
		COG5048	<298..>383	CDD:227381	32/84 (38%)
		C2H2 Zn finger	319..339	CDD:275368	5/19 (26%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		ZnF_U1	375..407	CDD:197732	8/23 (35%)
		C2H2 Zn finger	378..396	CDD:275368	7/17 (41%)
ZNF557	NP_001037852.1	KRAB	43..100	CDD:214630	16/69 (23%)
		KRAB	43..82	CDD:279668	8/44 (18%)
		COG5048	<137..422	CDD:227381	70/230 (30%)
		C2H2 Zn finger	154..174	CDD:275368	2/19 (11%)
		C2H2 Zn finger	182..202	CDD:275368	9/39 (23%)
		zf-H2C2_2	194..219	CDD:290200	10/25 (40%)
		C2H2 Zn finger	210..230	CDD:275368	10/19 (53%)
		zf-H2C2_2	222..247	CDD:290200	8/24 (33%)
		C2H2 Zn finger	238..258	CDD:275368	6/20 (30%)
		zf-H2C2_2	254..275	CDD:290200	11/21 (52%)
		C2H2 Zn finger	266..286	CDD:275368	5/19 (26%)
		C2H2 Zn finger	294..314	CDD:275368	8/19 (42%)
		zf-C2H2	320..342	CDD:278523	7/22 (32%)
		C2H2 Zn finger	322..342	CDD:275368	7/20 (35%)
		zf-H2C2_2	334..359	CDD:290200	2/8 (25%)
		C2H2 Zn finger	350..370	CDD:275368
		zf-H2C2_2	362..386	CDD:290200
		C2H2 Zn finger	378..398	CDD:275368
		zf-H2C2_2	390..415	CDD:290200
		C2H2 Zn finger	406..426	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960