DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17806 and ZNF154

DIOPT Version :9

Sequence 1:	NP_650658.1	Gene:	CG17806 / 42142	FlyBaseID:	FBgn0038548	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001078853.1	Gene:	ZNF154 / 7710	HGNCID:	12939	Length:	437	Species:	Homo sapiens

Alignment Length:	188	Identity:	68/188 - (36%)
Similarity:	99/188 - (52%)	Gaps:	14/188 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 ECPGKDMAKIENI-DSTTNKTKEEKYATRNKWGAAKRAYAL-EHRL-------YFCDQCGKTFSE 271
            || ||..:|..:: |.....|.|:.|..|....:.:::.:| :||.       :.||:|||.||.
Human   165 EC-GKSFSKSYSLNDHWRLHTGEKPYECRECGKSFRQSSSLIQHRRVHTAVRPHECDECGKLFSN 228

  Fly   272 KGNFNVHLRRHKGTKEFQCQECDRMEFTQHLLNLHVRIKHRGELPYVCKYCGKRFDNCLKRLNHE 336
            |.|...|.|.|.|.:.::|.||.: .|:|....|..|..|.||.||.|..|||.|......:.|:
Human   229 KSNLIKHRRVHTGERPYECSECGK-SFSQRSALLQHRGVHTGERPYECSECGKFFTYHSSLIKHQ 292

  Fly   337 RNHKESPVHRPHVCSTCQKAFKTSTALKDHIVVHTGEQPFHCELCQTFFNRRNALATH 394
            :.|..|   ||:.||.|.|:|..:::|.:|..|||||:|:.|..|...|::|:||..|
Human   293 KVHSGS---RPYECSECGKSFSQNSSLIEHHRVHTGERPYKCSECGKSFSQRSALLQH 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17806	NP_650658.1	zf-AD	4..76	CDD:285071
		zf-C2H2	260..282	CDD:278523	11/21 (52%)
		C2H2 Zn finger	262..282	CDD:275368	11/19 (58%)
		C2H2 Zn finger	290..311	CDD:275368	7/20 (35%)
		COG5048	<298..>383	CDD:227381	34/84 (40%)
		C2H2 Zn finger	319..339	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		ZnF_U1	375..407	CDD:197732	8/20 (40%)
		C2H2 Zn finger	378..396	CDD:275368	7/17 (41%)
ZNF154	NP_001078853.1	KRAB	14..>62	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..129
		C2H2 Zn finger	135..155	CDD:275368
		COG5048	139..>436	CDD:227381	68/188 (36%)
		C2H2 Zn finger	163..183	CDD:275368	6/18 (33%)
		C2H2 Zn finger	191..211	CDD:275368	4/19 (21%)
		C2H2 Zn finger	219..239	CDD:275368	11/19 (58%)
		zf-H2C2_2	231..256	CDD:290200	9/25 (36%)
		C2H2 Zn finger	247..267	CDD:275368	7/20 (35%)
		C2H2 Zn finger	275..295	CDD:275368	6/19 (32%)
		zf-H2C2_2	287..312	CDD:290200	10/27 (37%)
		C2H2 Zn finger	303..323	CDD:275368	7/19 (37%)
		zf-H2C2_2	315..340	CDD:290200	11/24 (46%)
		C2H2 Zn finger	331..351	CDD:275368	7/17 (41%)
		C2H2 Zn finger	359..379	CDD:275368
		zf-H2C2_2	371..396	CDD:290200
		C2H2 Zn finger	387..407	CDD:275368
		zf-H2C2_2	400..424	CDD:290200
		C2H2 Zn finger	415..435	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050