DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17806 and ZNF24

DIOPT Version :9

Sequence 1:	NP_650658.1	Gene:	CG17806 / 42142	FlyBaseID:	FBgn0038548	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001362744.1	Gene:	ZNF24 / 7572	HGNCID:	13032	Length:	368	Species:	Homo sapiens

Alignment Length:	397	Identity:	90/397 - (22%)
Similarity:	150/397 - (37%)	Gaps:	117/397 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RDVLSNILKLTGFWLRNQPGVPTRICLSCLLDLNDAIAFRERCIRTNSSWFEKQGKQEDSDTETA 88
            |:.:|.:.:|...|||  |...|:..:..|:.|...:|...:.::|   |......:...:..|.
Human    67 REAVSQLRELCRLWLR--PETHTKEQILELVVLEQFVAILPKELQT---WVRDHHPENGEEAVTV 126

  Fly    89 REGGNNRLESRVD--VMPISIAQPQRRRILPQRSKKVDGVPLKTVETPIYPLVVPEIPPADLVDP 151
            .|.    |||.:|  ..|:|:.: ::|.:|              ||..:.......:|.::|
Human   127 LED----LESELDDPGQPVSLRR-RKREVL--------------VEDMVSQEEAQGLPSSEL--- 169

  Fly   152 LRCEDPIQVKSEPQLS-SDYPVESMNHEE-----------PASEMPQVMK--EEPRTLQVIGEVQ 202
                |.:    |.||. :.:.:.|:.|.:           |..|:|..::  |.|.||
Human   170 ----DAV----ENQLKWASWELHSLRHCDDDGRTENGALAPKQELPSALESHEVPGTL------- 219

  Fly   203 KNRRKPRSKGCLEECPGKDMAKIENIDSTTNKTKEEKYATRNKWGAAKRAYALEHRLYFCDQCGK 267
             |...|:.....|.|..|            .:.:.::..:|.|          :|   .||:|||
Human   220 -NMGVPQIFKYGETCFPK------------GRFERKRNPSRKK----------QH---ICDECGK 258

  Fly   268 TFSEKGNFNVHLRRHKGTKEFQCQECDRMEFTQHLLNLHVRIKHRGELPYVCKYCGKRFDNCLKR 332
            .||:.....:|.|.|.|.|.:.|.||.:......:|..|.|: |.||.||.|..|||.|......
Human   259 HFSQGSALILHQRIHSGEKPYGCVECGKAFSRSSILVQHQRV-HTGEKPYKCLECGKAFSQNSGL 322

  Fly   333 LNHERNHKESPVHRPHVCSTCQKAFKTSTALKDHIVVHTGEQPFHCELCQTFFNRRNALATHYKS 397
            :||:|                               :||||:|:.|..|...:::.:.|..|.:
Human   323 INHQR-------------------------------IHTGEKPYECVQCGKSYSQSSNLFRHQR- 355

  Fly   398 KHHRLKV 404
            :|:..|:
Human   356 RHNAEKL 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17806	NP_650658.1	zf-AD	4..76	CDD:285071	13/51 (25%)
		zf-C2H2	260..282	CDD:278523	9/21 (43%)
		C2H2 Zn finger	262..282	CDD:275368	9/19 (47%)
		C2H2 Zn finger	290..311	CDD:275368	6/20 (30%)
		COG5048	<298..>383	CDD:227381	23/84 (27%)
		C2H2 Zn finger	319..339	CDD:275368	8/19 (42%)
		C2H2 Zn finger	350..370	CDD:275368	0/19 (0%)
		ZnF_U1	375..407	CDD:197732	7/30 (23%)
		C2H2 Zn finger	378..396	CDD:275368	4/17 (24%)
ZNF24	NP_001362744.1	SCAN	48..160	CDD:128708	25/116 (22%)
		COG5048	<249..329	CDD:227381	33/124 (27%)
		Necessary and sufficient for nuclear localization	251..301		19/53 (36%)
		C2H2 Zn finger	253..273	CDD:275368	9/19 (47%)
		C2H2 Zn finger	281..301	CDD:275368	6/20 (30%)
		COG5048	305..>358	CDD:227381	19/84 (23%)
		C2H2 Zn finger	309..329	CDD:275368	8/50 (16%)
		C2H2 Zn finger	337..357	CDD:275368	4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050