DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17806 and ZNF19

DIOPT Version :9

Sequence 1:	NP_650658.1	Gene:	CG17806 / 42142	FlyBaseID:	FBgn0038548	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_008892.2	Gene:	ZNF19 / 7567	HGNCID:	12981	Length:	458	Species:	Homo sapiens

Alignment Length:	261	Identity:	78/261 - (29%)
Similarity:	119/261 - (45%)	Gaps:	36/261 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 QVKSEPQLSSDYPVESMNHEEPASEMPQVMKEEPRTLQVIGEVQK--NRRKPRSKGCLEECPGKD 221
            |:||.|| .:|:| |:.|.|:        .::.|....:.|:|.:  ..|||   ...||| ||.
Human   119 QLKSVPQ-RTDFP-ETRNVEK--------HQDIPTVKNIQGKVPRIPCARKP---FICEEC-GKS 169

  Fly   222 MAKIENIDSTTNKTKEEKYATRNKWGAA----------KRAYALEHRLYFCDQCGKTFSEKGNFN 276
            .:..............||....::.|.|          :|.:..| |.|.|::||:.|::..|..
Human   170 FSYFSYYARHQRIHTGEKPFECSECGKAFNGNSSLIRHQRIHTGE-RPYQCEECGRAFNDNANLI 233

  Fly   277 VHLRRHKGTKEFQCQECDRMEFTQHLLNLHVRIKHRGELPYVCKYCGKRFDNCLKRLNHERNHKE 341
            .|.|.|.|.:.:.|.||.....:.....:|.|| |.||.||.|..|||.|......|.|::.|..
Human   234 RHQRIHSGDRPYYCTECGNSFTSSSEFVIHQRI-HTGEKPYECNECGKAFVGNSPLLRHQKIHTG 297

  Fly   342 SPVHRPHVCSTCQKAFKTSTALKDHIVVHTGEQPFHCELCQTFFNRRNALATHYKSKHHRLKVEE 406
               .:|:.|:.|.|:|..::.|..|..:||||:|:.|::|...||....|     ::|.|:..||
Human   298 ---EKPYECNECGKSFGRTSHLSQHQRIHTGEKPYSCKVCGQAFNFHTKL-----TRHQRIHSEE 354

  Fly   407 Q 407
            :
Human   355 K 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17806	NP_650658.1	zf-AD	4..76	CDD:285071
		zf-C2H2	260..282	CDD:278523	8/21 (38%)
		C2H2 Zn finger	262..282	CDD:275368	7/19 (37%)
		C2H2 Zn finger	290..311	CDD:275368	6/20 (30%)
		COG5048	<298..>383	CDD:227381	30/84 (36%)
		C2H2 Zn finger	319..339	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	6/19 (32%)
		ZnF_U1	375..407	CDD:197732	9/31 (29%)
		C2H2 Zn finger	378..396	CDD:275368	5/17 (29%)
ZNF19	NP_008892.2	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		COG5048	<96..426	CDD:227381	78/261 (30%)
		C2H2 Zn finger	163..183	CDD:275368	5/20 (25%)
		zf-H2C2_2	178..199	CDD:290200	4/20 (20%)
		C2H2 Zn finger	191..211	CDD:275368	3/19 (16%)
		zf-H2C2_2	203..227	CDD:290200	7/24 (29%)
		C2H2 Zn finger	219..239	CDD:275368	7/19 (37%)
		zf-H2C2_2	231..256	CDD:290200	8/24 (33%)
		C2H2 Zn finger	247..267	CDD:275368	6/20 (30%)
		zf-H2C2_2	263..283	CDD:290200	12/20 (60%)
		C2H2 Zn finger	275..295	CDD:275368	7/19 (37%)
		zf-H2C2_2	288..312	CDD:290200	8/26 (31%)
		C2H2 Zn finger	303..323	CDD:275368	6/19 (32%)
		zf-H2C2_2	315..339	CDD:290200	9/23 (39%)
		C2H2 Zn finger	331..351	CDD:275368	7/24 (29%)
		zf-H2C2_2	344..367	CDD:290200	5/17 (29%)
		C2H2 Zn finger	359..379	CDD:275368
		zf-H2C2_2	372..393	CDD:290200
		C2H2 Zn finger	387..407	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960