DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17806 and ZNF3

DIOPT Version :9

Sequence 1:	NP_650658.1	Gene:	CG17806 / 42142	FlyBaseID:	FBgn0038548	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001305065.1	Gene:	ZNF3 / 7551	HGNCID:	13089	Length:	453	Species:	Homo sapiens

Alignment Length:	253	Identity:	77/253 - (30%)
Similarity:	110/253 - (43%)	Gaps:	35/253 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 PVESMNHEEPASEMPQVMKEE---PR------------TLQVIGEVQKNRRKP---RSKGCLEEC 217
            |.|.:|.:.|  :..||..||   ||            :..|...:..::|.|   |...| :||
Human   151 PGERLNRKMP--DFGQVTVEEKLTPRGERSEKYNDFGNSFTVNSNLISHQRLPVGDRPHKC-DEC 212

  Fly   218 PGKDMAKIENIDSTTNKTKEEKYATRNKWGAA--KRAYALEH-------RLYFCDQCGKTFSEKG 273
            ........:.|......|.|:.|.. |:.|.|  :.::.::|       :.|.|..||||||...
Human   213 SKSFNRTSDLIQHQRIHTGEKPYEC-NECGKAFSQSSHLIQHQRIHTGEKPYECSDCGKTFSCSS 276

  Fly   274 NFNVHLRRHKGTKEFQCQECDRMEFTQHLLNLHVRIKHRGELPYVCKYCGKRFDNCLKRLNHERN 338
            ...:|.|.|.|.|.::|.||.:.......|..|.|| |.||.||.|..|||.|......::|:|.
Human   277 ALILHRRIHTGEKPYECNECGKTFSWSSTLTHHQRI-HTGEKPYACNECGKAFSRSSTLIHHQRI 340

  Fly   339 HKESPVHRPHVCSTCQKAFKTSTALKDHIVVHTGEQPFHCELCQTFFNRRNALATHYK 396
            |..   .:|:.|:.|.|||..|:.|..|..:||||:|:.|..|...|...:.|..|.:
Human   341 HTG---EKPYECNECGKAFSQSSHLYQHQRIHTGEKPYECMECGGKFTYSSGLIQHQR 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17806	NP_650658.1	zf-AD	4..76	CDD:285071
		zf-C2H2	260..282	CDD:278523	10/21 (48%)
		C2H2 Zn finger	262..282	CDD:275368	9/19 (47%)
		C2H2 Zn finger	290..311	CDD:275368	7/20 (35%)
		COG5048	<298..>383	CDD:227381	33/84 (39%)
		C2H2 Zn finger	319..339	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		ZnF_U1	375..407	CDD:197732	6/22 (27%)
		C2H2 Zn finger	378..396	CDD:275368	5/17 (29%)
ZNF3	NP_001305065.1	KRAB	57..98	CDD:366587
		COG5048	<182..360	CDD:227381	54/183 (30%)
		C2H2 Zn finger	185..201	CDD:275368	2/15 (13%)
		C2H2 Zn finger	209..229	CDD:275368	4/20 (20%)
		C2H2 Zn finger	237..257	CDD:275368	4/20 (20%)
		C2H2 Zn finger	265..285	CDD:275368	9/19 (47%)
		C2H2 Zn finger	293..313	CDD:275368	7/20 (35%)
		C2H2 Zn finger	321..341	CDD:275368	7/19 (37%)
		C2H2 Zn finger	349..369	CDD:275368	8/19 (42%)
		zf-H2C2_2	361..386	CDD:372612	10/24 (42%)
		C2H2 Zn finger	377..397	CDD:275368	5/19 (26%)
		zf-H2C2_2	390..414	CDD:372612	2/6 (33%)
		C2H2 Zn finger	405..425	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960