DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17806 and ZKSCAN7

DIOPT Version :9

Sequence 1:	NP_650658.1	Gene:	CG17806 / 42142	FlyBaseID:	FBgn0038548	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001275519.1	Gene:	ZKSCAN7 / 55888	HGNCID:	12955	Length:	754	Species:	Homo sapiens

Alignment Length:	465	Identity:	110/465 - (23%)
Similarity:	170/465 - (36%)	Gaps:	114/465 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 RDVLSNILKLTGFWLRNQPGVPTRICLSCLLDLNDAIAFRERCIRTNSSWFEKQGKQEDSDTETA 88
            ::.||.:.:|..:||  .|.|.|:..:..||.|...::.....:||   |.:....:...:....
Human    69 QEALSRLRELCRWWL--MPEVHTKEQILELLVLEQFLSILPGELRT---WVQLHHPESGEEAVAV 128

  Fly    89 REGGNNRLESRVDVMPISIAQPQRRRILPQRSKKVDGVPLKTVETPIYPLVVPEIPPADLVDP-- 151
            .|.....|....:|.  :.||.|....     ::...:.......|..||.....|.|.|..|
Human   129 VEDFQRHLSGSEEVS--APAQKQEMHF-----EETTALGTTKESPPTSPLSGGSAPGAHLEPPYD 186

  Fly   152 -----------LRCEDPI----QVKS-------------EPQ-------LSSDYPVESM------ 175
                       .:|..|:    ||.:             .||       ||.||..:..
Human   187 PGTHHLPSGDFAQCTSPVPTLPQVGNSGDQAGATVLRMVRPQDTVAYEDLSVDYTQKKWKSLTLS 251

  Fly   176 -----------NHEEPAS----EMPQVMKEEPRTLQVIGEVQKNRRKPRSKGCLEECPG------ 219
                       ||...||    .|.:..:..|:.....|....||   .|.|.....||
Human   252 QRALQWNMMPENHHSMASLAGENMMKGSELTPKQEFFKGSESSNR---TSGGLFGVVPGAAETGD 313

  Fly   220 ---------------KDMAKIENIDSTTNKTKEEKYATRNKWGAAKR--------AYALEH---- 257
                           ::.:::|| |......:::|.:|::::...|.        :..:||
Human   314 VCEDTFKELEGQTSDEEGSRLEN-DFLEITDEDKKKSTKDRYDKYKEVGEHPPLSSSPVEHEGVL 377

  Fly   258 ---RLYFCDQCGKTFSEKGNFNVHLRRHKGTKEFQCQECDRMEFTQHLLNLHVRIKHRGELPYVC 319
               :.|.||:|||.|:...:...|.|.|.|.|.::|.||.:.......|.:|:| .|.||.||.|
Human   378 KGQKSYRCDECGKAFNRSSHLIGHQRIHTGEKPYECNECGKTFRQTSQLIVHLR-THTGEKPYEC 441

  Fly   320 KYCGKRFDNCLKRLNHERNHKESPVHRPHVCSTCQKAFKTSTALKDHIVVHTGEQPFHCELCQTF 384
            ..|||.:.:....:.|:|.|..   .:|:.|:.|.|||..|:.|.||...||||:|:.|..|...
Human   442 SECGKAYRHSSHLIQHQRLHNG---EKPYKCNECAKAFTQSSRLTDHQRTHTGEKPYECNECGEA 503

  Fly   385 FNRRNALATH 394
            |.|..:||.|
Human   504 FIRSKSLARH 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17806	NP_650658.1	zf-AD	4..76	CDD:285071	14/51 (27%)
		zf-C2H2	260..282	CDD:278523	9/21 (43%)
		C2H2 Zn finger	262..282	CDD:275368	8/19 (42%)
		C2H2 Zn finger	290..311	CDD:275368	6/20 (30%)
		COG5048	<298..>383	CDD:227381	32/84 (38%)
		C2H2 Zn finger	319..339	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..370	CDD:275368	9/19 (47%)
		ZnF_U1	375..407	CDD:197732	8/20 (40%)
		C2H2 Zn finger	378..396	CDD:275368	7/17 (41%)
ZKSCAN7	NP_001275519.1	SCAN	51..161	CDD:128708	20/103 (19%)
		SCAN	51..138	CDD:280241	16/73 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..215		11/57 (19%)
		KRAB_A-box	231..270	CDD:143639	7/38 (18%)
		COG5048	380..738	CDD:227381	52/138 (38%)
		zf-C2H2	383..405	CDD:278523	9/21 (43%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
		zf-H2C2_2	401..422	CDD:290200	8/20 (40%)
		C2H2 Zn finger	413..433	CDD:275368	6/20 (30%)
		zf-H2C2_2	426..450	CDD:290200	12/24 (50%)
		C2H2 Zn finger	441..461	CDD:275368	6/19 (32%)
		zf-H2C2_2	453..478	CDD:290200	9/27 (33%)
		C2H2 Zn finger	469..489	CDD:275368	9/19 (47%)
		zf-H2C2_2	482..506	CDD:290200	11/23 (48%)
		C2H2 Zn finger	497..517	CDD:275368	7/17 (41%)
		zf-H2C2_2	509..532	CDD:290200	3/5 (60%)
		C2H2 Zn finger	525..545	CDD:275368
		zf-H2C2_2	537..562	CDD:290200
		C2H2 Zn finger	553..573	CDD:275368
		zf-H2C2_2	566..590	CDD:290200
		C2H2 Zn finger	581..601	CDD:275368
		zf-H2C2_2	594..616	CDD:290200
		C2H2 Zn finger	609..629	CDD:275368
		zf-H2C2_2	622..646	CDD:290200
		C2H2 Zn finger	637..657	CDD:275368
		zf-H2C2_2	649..674	CDD:290200
		C2H2 Zn finger	665..685	CDD:275368
		zf-H2C2_2	677..701	CDD:290200
		C2H2 Zn finger	693..713	CDD:275368
		zf-H2C2_2	706..730	CDD:290200
		C2H2 Zn finger	721..741	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..754
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050