DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG17806 and topi

DIOPT Version :10

Sequence 1:NP_650658.1 Gene:CG17806 / 42142 FlyBaseID:FBgn0038548 Length:421 Species:Drosophila melanogaster
Sequence 2:NP_649945.1 Gene:topi / 41199 FlyBaseID:FBgn0037751 Length:814 Species:Drosophila melanogaster


Alignment Length:603 Identity:134/603 - (22%)
Similarity:197/603 - (32%) Gaps:230/603 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 QEAEHAKSLFDKEA-----RDVLSNIL--KLT-------GFWLRNQPGVPTRI-CLSCLLDLNDA 59
            |||:..|. ||.:|     ||.|:.:.  |:|       |....:......|| |.:||:.. ||
  Fly    86 QEADGKKG-FDPQAEQMKIRDFLAGVTSSKMTTEQSVFHGSRSNSSASTVNRIKCPTCLVQF-DA 148

  Fly    60 IAFR-------------------------------------ERCIRTNSSWFEKQGKQE------ 81
            :||:                                     ||.||.|.....:..|.|      
  Fly   149 VAFQNHSCEAKPIEVAVPQQEKPHLVPTVSAPPAPLSKPASERVIRENQVRLRRYIKDEMKYDLA 213

  Fly    82 ---DSDTETAREGGNN-RLESRVDVMPISIAQPQRRRILPQRSKKVDGVPLKTVETPIYPLVVPE 142
               :|..:.|.:|.|. .:..|..|....:.:...:..|       |.:|.:|.|.|      ..
  Fly   214 TGIESSRKNAAKGPNECTMCDRKFVHASGLVRHMEKHAL-------DLIPSQTSEQP------HT 265

  Fly   143 IPPADLVDPLRCEDPIQVKSEPQLSSDYPV-----ESMNHEEPASEMP----------------- 185
            ||.|.|...::|....::..:||::..:.:     .|...:.|.:::|                 
  Fly   266 IPAAGLHVVVKCNSCGRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLI 330

  Fly   186 -------------QVMKEEPRTLQVIG------------------------------------EV 201
                         ...|:|..:..::|                                    ::
  Fly   331 DNDPAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDI 395

  Fly   202 QKNRRK------------------------------------------------------PR--- 209
            |.|..|                                                      ||   
  Fly   396 QMNTAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNE 460

  Fly   210 -SKGCLEECPGKD---------MAKIENIDSTTNKTKEEKYATRNKWGAAKRAYALEHRLYFCDQ 264
             .|..|..|...|         :|..|  :...||.|.|| .|||. ||.:      .|.|.||.
  Fly   461 NGKKLLLPCDFCDVNFEFAHDFLAHSE--EKHLNKKKREK-ETRNT-GAGR------IRQYLCDI 515

  Fly   265 CGKTFSEKGNFNVHLRRHKGTKEFQCQE--CDRMEFTQHLLNLHVRIKHRGELPYVCKYCGKRFD 327
            |||::::..:...|||.|:|.|.|.|||  |||....:..||.|:|..|.||.||:|..|||||.
  Fly   516 CGKSYTQSSHLWQHLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFL 580

  Fly   328 NCLKRLNHERNHKESPVHRPHVCSTCQKAFKTSTALKDHIVVHTGEQPFHCELCQTFFNRRNALA 392
            .......|...|:.   .|.:.|..|.|.|..:.|||:|..:||||:|:.|..|...|.:|....
  Fly   581 TGSVFYQHRLIHRG---ERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRD 642

  Fly   393 THYKSKHHRLKVEEQSKM 410
            .|.:::|..|....:..|
  Fly   643 KHIRARHSHLDANSRLMM 660

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17806NP_650658.1 zf-AD 4..75 CDD:462262 27/116 (23%)
zf-C2H2 260..282 CDD:395048 9/21 (43%)
C2H2 Zn finger 262..282 CDD:275368 8/19 (42%)
C2H2 Zn finger 290..311 CDD:275368 10/22 (45%)
C2H2 Zn finger 319..339 CDD:275368 7/19 (37%)
C2H2 Zn finger 350..370 CDD:275368 8/19 (42%)
ZnF_U1 375..407 CDD:197732 8/31 (26%)
C2H2 Zn finger 378..396 CDD:275368 5/17 (29%)
topiNP_649945.1 C2H2 Zn finger 230..250 CDD:275370 2/19 (11%)
C2H2 Zn finger 277..297 CDD:275370 3/19 (16%)
C2H2 Zn finger 431..453 CDD:275368 0/21 (0%)
COG5048 <450..647 CDD:227381 74/209 (35%)
C2H2 Zn finger 469..490 CDD:275368 4/22 (18%)
C2H2 Zn finger 513..564 CDD:275368 22/50 (44%)
C2H2 Zn finger 541..561 CDD:275368 9/19 (47%)
C2H2 Zn finger 572..592 CDD:275368 7/19 (37%)
C2H2 Zn finger 600..620 CDD:275368 8/19 (42%)
zf-H2C2_2 612..637 CDD:463886 12/24 (50%)
C2H2 Zn finger 628..646 CDD:275368 5/17 (29%)

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