DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17806 and M1BP

DIOPT Version :9

Sequence 1:	NP_650658.1	Gene:	CG17806 / 42142	FlyBaseID:	FBgn0038548	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_649825.1	Gene:	M1BP / 41042	FlyBaseID:	FBgn0037621	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	449	Identity:	121/449 - (26%)
Similarity:	190/449 - (42%)	Gaps:	107/449 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTLCRTCGQEAEHAKS--LFDKEARDVLSNILKLTGFWLRNQPGVPTRICLSCLLDLNDAIAFR 63
            :.:.||.|.:.|.:.:|  ||::....::.||..|||..|.|...:|.:||..|.::|..|:..|
  Fly     9 LKSTCRVCAKYASNKRSPKLFERSNTKMIDNIEALTGLRLENYGCLPDQICECCSMELASAVKLR 73

  Fly    64 ERCIRTNSSWFEKQGKQEDSDTETAREGGNNRLESRVDVMPISIAQPQRRRILPQRSKKVDGVPL 128
            ||||...                  ||            :.:.:.:.||:.|.......|.|..:
  Fly    74 ERCIAAQ------------------RE------------LLLGLTEEQRQGISAFYRAAVMGEDI 108

  Fly   129 -KTVETP-------IYPLVVPEIPPADLVDPLRCE----------------DPIQVKSEPQLSSD 169
             :||:||       .|..:|.| .|.:.:|..:.|                |...:..|    :|
  Fly   109 VQTVKTPDDDEVYATYQEIVLE-EPKEEIDDTKVEYDNTYYEVAEGHAGEDDAASLIEE----AD 168

  Fly   170 YPVESMNHEEPASEMPQVMKEEPRTLQVIGEVQK-----------------NRRKPRSKGCLEEC 217
            |  :|:..|:  .|..|.::.:..|..::|:|..                 :.........:::|
  Fly   169 Y--DSIMAED--EEQQQTLELDEDTELIVGDVNDAYVYDSDDEVAVLDNVLDDEYEHENIVVKKC 229

  Fly   218 PGKDMAKIENIDSTTNKTKEEKYATRNKWGAAKRAYALEHRLYFCDQCGKTFSEKGNFNVHLRRH 282
            ......|:.:.|           |.|...|.          :|.|:|||.....:..|.:|.|||
  Fly   230 SLPPKPKVRSDD-----------ARRRGTGG----------VYICEQCGNHIKGRMAFELHCRRH 273

  Fly   283 KGTKEFQCQECDRMEFTQHLLNLHVRIKHRGELPYVCKYCGKRFDNCLKRLNHERNHKESPVHRP 347
            :|.|:|.|:.|.....|...|..|:| ||.||.|:.|||||:.|.:...|:.|||.|..   .||
  Fly   274 RGDKQFGCELCQSRFCTTSELKRHMR-KHTGERPFACKYCGRCFTDYTTRVKHERTHTN---ERP 334

  Fly   348 HVCSTCQKAFKTSTALKDHIVVHTGEQPFHCELCQTFFNRRNALATHYKSKHHRLKVEE 406
            :||.||.|||.|...||:|:::|:||:.:.||||...|.....|:||::|..|:..:|:
  Fly   335 YVCGTCGKAFTTGYILKNHMLIHSGERAYRCELCDKSFMLPTHLSTHFRSGVHKRHLEK 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17806	NP_650658.1	zf-AD	4..76	CDD:285071	25/73 (34%)
		zf-C2H2	260..282	CDD:278523	8/21 (38%)
		C2H2 Zn finger	262..282	CDD:275368	7/19 (37%)
		C2H2 Zn finger	290..311	CDD:275368	6/20 (30%)
		COG5048	<298..>383	CDD:227381	40/84 (48%)
		C2H2 Zn finger	319..339	CDD:275368	10/19 (53%)
		C2H2 Zn finger	350..370	CDD:275368	10/19 (53%)
		ZnF_U1	375..407	CDD:197732	11/32 (34%)
		C2H2 Zn finger	378..396	CDD:275368	8/17 (47%)
M1BP	NP_649825.1	zf-AD	13..84	CDD:214871	27/100 (27%)
		C2H2 Zn finger	253..273	CDD:275368	7/19 (37%)
		COG5048	276..>331	CDD:227381	24/55 (44%)
		C2H2 Zn finger	281..301	CDD:275368	6/20 (30%)
		zf-H2C2_2	293..317	CDD:290200	13/24 (54%)
		C2H2 Zn finger	309..329	CDD:275368	10/19 (53%)
		zf-H2C2_2	324..346	CDD:290200	13/24 (54%)
		C2H2 Zn finger	337..357	CDD:275368	10/19 (53%)
		zf-H2C2_2	350..372	CDD:290200	10/21 (48%)
		C2H2 Zn finger	365..383	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I19075
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	62	1.000	Inparanoid score	I2531
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000724
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_120097
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.860