DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17806 and ZNF662

DIOPT Version :9

Sequence 1:	NP_650658.1	Gene:	CG17806 / 42142	FlyBaseID:	FBgn0038548	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001128128.1	Gene:	ZNF662 / 389114	HGNCID:	31930	Length:	452	Species:	Homo sapiens

Alignment Length:	224	Identity:	75/224 - (33%)
Similarity:	100/224 - (44%)	Gaps:	39/224 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 EECPGKDMAKIENIDSTTNKTKEEKYATRNKWGAA--KRAYALEH-------RLYFCDQCGKTFS 270
            ||| ||...:.|:.|........||.....:.|.|  .|::.:.|       :.|.|.:|.|.|.
Human   221 EEC-GKCFDQNEDFDQHQKTHNGEKVYGCKECGKAFSFRSHCIAHQRIHSGVKPYECQECAKAFV 284

  Fly   271 EKGNFNVHLRRHKGTKEFQCQECDRMEFTQHL-LNLHVRIKHRGELPYVCKYCGKRFDNCLKRLN 334
            .|.|...|.|.|.|.|.|:|:||.: .|:|:. |..|.|| |.||.||.||.|||.|......|.
Human   285 WKSNLIRHQRIHTGEKPFECKECGK-GFSQNTSLTQHQRI-HTGEKPYTCKECGKSFTRNPALLR 347

  Fly   335 HERNHK-ESP---------------------VH---RPHVCSTCQKAFKTSTALKDHIVVHTGEQ 374
            |:|.|. |.|                     ||   :||.|:.|.|:|.....|..|..:||||:
Human   348 HQRMHTGEKPYECKDCGKGFMWNSDLSQHQRVHTGDKPHECTDCGKSFFCKAHLIRHQRIHTGER 412

  Fly   375 PFHCELCQTFFNRRNALATHYKSKHHRLK 403
            |:.|..|...|::.:.|..|.: :|.|.|
Human   413 PYKCNDCGKAFSQNSVLIKHQR-RHARDK 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17806	NP_650658.1	zf-AD	4..76	CDD:285071
		zf-C2H2	260..282	CDD:278523	9/21 (43%)
		C2H2 Zn finger	262..282	CDD:275368	8/19 (42%)
		C2H2 Zn finger	290..311	CDD:275368	9/21 (43%)
		COG5048	<298..>383	CDD:227381	40/110 (36%)
		C2H2 Zn finger	319..339	CDD:275368	9/19 (47%)
		C2H2 Zn finger	350..370	CDD:275368	6/19 (32%)
		ZnF_U1	375..407	CDD:197732	9/29 (31%)
		C2H2 Zn finger	378..396	CDD:275368	5/17 (29%)
ZNF662	NP_001128128.1	KRAB	33..92	CDD:214630
		KRAB	33..72	CDD:279668
		C2H2 Zn finger	220..240	CDD:275368	7/19 (37%)
		C2H2 Zn finger	248..268	CDD:275368	4/19 (21%)
		zf-H2C2_2	264..284	CDD:290200	5/19 (26%)
		COG5048	<272..427	CDD:227381	57/156 (37%)
		C2H2 Zn finger	276..296	CDD:275368	8/19 (42%)
		zf-H2C2_2	288..313	CDD:290200	11/25 (44%)
		C2H2 Zn finger	304..324	CDD:275368	9/21 (43%)
		zf-H2C2_2	316..341	CDD:290200	15/25 (60%)
		C2H2 Zn finger	332..352	CDD:275368	9/19 (47%)
		zf-H2C2_2	344..367	CDD:290200	6/22 (27%)
		C2H2 Zn finger	360..380	CDD:275368	0/19 (0%)
		zf-H2C2_2	372..395	CDD:290200	7/22 (32%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		zf-H2C2_2	400..425	CDD:290200	10/24 (42%)
		C2H2 Zn finger	416..436	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050