DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG17806 and ZNF517

DIOPT Version :9

Sequence 1:NP_650658.1 Gene:CG17806 / 42142 FlyBaseID:FBgn0038548 Length:421 Species:Drosophila melanogaster
Sequence 2:NP_001371833.1 Gene:ZNF517 / 340385 HGNCID:27984 Length:492 Species:Homo sapiens


Alignment Length:317 Identity:88/317 - (27%)
Similarity:118/317 - (37%) Gaps:80/317 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   164 PQLSSDYPVESMNHEEPASEMPQVMKEE---------PRTLQVIG------------EVQKNRRK 207
            |:..||.|......|..||  |:|::|:         ||...|.|            ::.....|
Human   141 PEDGSDKPTHPRAREHSAS--PRVLQEDLGRPVGSSAPRYRCVCGKAFRYNSLLLRHQIIHTGAK 203

  Fly   208 PRSKGCLEECPGKDMAKIENIDSTTNKTKEEKYATRNKWGAAKR---AYALEHRL------YFCD 263
            |..  | .|| ||...:...:........|||.....:.|.|.|   ..|..||:      |.|.
Human   204 PFQ--C-TEC-GKAFKQSSILLRHQLIHTEEKPFQCGECGKAFRQSTQLAAHHRVHTRERPYACG 264

  Fly   264 QCGKTFSEKGNFNVHLRRHKGTKEFQCQECDRMEFTQHLLNLHVRIKHRGELPYVCKYCGKRFDN 328
            :|||.||.......|.:.|.|.|.|.|.||.:....:..||.|.|| |.||.||.|..||:||..
Human   265 ECGKAFSRSSRLLQHQKFHTGEKPFACTECGKAFCRRFTLNEHGRI-HSGERPYRCLRCGQRFIR 328

  Fly   329 CLKRLNHERNHKESPVH--------------------RPHVCSTCQKAFKTSTALKDHIVVHTGE 373
            ....|.|.|.|.:....                    .||.|..|.:.|:.::.|..|:.:||||
Human   329 GSSLLKHHRLHAQEGAQDGGVGQGALLGAAQRPQAGDPPHECPVCGRPFRHNSLLLLHLRLHTGE 393

  Fly   374 QPFHCELCQTFFNRRNALATHYK-----------------------SKHHRLKVEEQ 407
            :||.|..|...|.|::.|..|.|                       ::|:||...|:
Human   394 KPFECAECGKAFGRKSNLTLHQKIHTKEKPFACTECGKAFRRSYTLNEHYRLHSGER 450

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17806NP_650658.1 zf-AD 4..76 CDD:285071
zf-C2H2 260..282 CDD:278523 8/21 (38%)
C2H2 Zn finger 262..282 CDD:275368 7/19 (37%)
C2H2 Zn finger 290..311 CDD:275368 8/20 (40%)
COG5048 <298..>383 CDD:227381 34/104 (33%)
C2H2 Zn finger 319..339 CDD:275368 8/19 (42%)
C2H2 Zn finger 350..370 CDD:275368 5/19 (26%)
ZnF_U1 375..407 CDD:197732 12/54 (22%)
C2H2 Zn finger 378..396 CDD:275368 6/17 (35%)
ZNF517NP_001371833.1 KRAB 14..73 CDD:214630
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 129..170 10/30 (33%)
C2H2 Zn finger 180..199 CDD:275368 2/18 (11%)
COG5048 <203..342 CDD:227381 50/143 (35%)
C2H2 Zn finger 207..227 CDD:275368 5/21 (24%)
C2H2 Zn finger 235..255 CDD:275368 6/19 (32%)
C2H2 Zn finger 263..283 CDD:275368 7/19 (37%)
COG5048 <287..459 CDD:227381 48/165 (29%)
C2H2 Zn finger 291..311 CDD:275368 8/20 (40%)
C2H2 Zn finger 319..339 CDD:275368 8/19 (42%)
C2H2 Zn finger 370..390 CDD:275368 5/19 (26%)
C2H2 Zn finger 398..418 CDD:275368 7/19 (37%)
C2H2 Zn finger 426..446 CDD:275368 2/19 (11%)
C2H2 Zn finger 454..474 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 472..492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 123 1.000 Inparanoid score I4733
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.050

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