DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17806 and ZNF354C

DIOPT Version :9

Sequence 1:	NP_650658.1	Gene:	CG17806 / 42142	FlyBaseID:	FBgn0038548	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_055409.1	Gene:	ZNF354C / 30832	HGNCID:	16736	Length:	554	Species:	Homo sapiens

Alignment Length:	405	Identity:	93/405 - (22%)
Similarity:	165/405 - (40%)	Gaps:	77/405 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LLDLNDAIAFRERCI-RTNSSWFEKQGKQEDSDTETAREGGNNRLESRVDV-MPISIAQPQR--- 112
            ||...:.:.||:..: .:...|......|.....|...|..::.:...:.. ||..|.|.|:
Human     5 LLSAQEPVTFRDVAVFFSQDEWLHLDSAQRALYREVMLENYSSLVSLGIPFSMPKLIHQLQQGED 69

  Fly   113 ----RRILPQRSKKVDGVPLKT-VETPIYP----LVVPE-----IPPADLVD---PLRCEDPIQV 160
                .|.:|..::    :..|| :||...|    :.:.|     :....:.|   .:..|:.::.
Human    70 PCMVEREVPSDTR----LGFKTWLETEALPHRQDIFIEETSQGMVKKESIKDGHWDINFEEAVEF 130

  Fly   161 KSEPQLSSDYPVESMNHEEPASEMPQVMKEEPRTLQVIG-----EVQKNRRKPRSKGCLEECPGK 220
            :||        :|....::|   :.|::....:|:...|     |:.|:.....:....:..|
Human   131 ESE--------IEEEQEKKP---LRQMIDSHEKTISEDGNHTSLELGKSLFTNTALVTQQSVP-- 182

  Fly   221 DMAKIENIDSTTNKTKEEKYATR--------------NKWGAA--KRAYALEH-------RLYFC 262
             :.:|.|:..|..|..::.:...              |:.|.:  :..:.:||       :.|.|
Human   183 -IERIPNMYYTFGKDFKQNFDLMKCFQIYPGGKPHICNECGKSFKQNLHLIEHQRIHTGEKPYKC 246

  Fly   263 DQCGKTFSEKGNFNVHLRRHKGTKEFQCQECDRMEFTQHLLNLHVRIKHRGELPYVCKYCGKRFD 327
            ::|.||||.:.:...|.|.|.|.|.::|.||::.......|..|:|: |.||.||.|:.|||.|.
Human   247 NECEKTFSHRSSLLSHQRIHTGEKPYKCNECEKAFSNSSTLIKHLRV-HTGEKPYRCRECGKAFS 310

  Fly   328 NCLKRLNHERNHKESPVHRPHVCSTCQKAFKTSTALKDHIVVHTGEQPFHCELCQTFFNRRNALA 392
            .|.....|:|.|....:::   |..|:|||.....|..|..:||||:|:.|..|...:::..:||
Human   311 QCSTLTVHQRIHTGEKLYK---CGECEKAFNCRAKLHRHQRIHTGEKPYKCSECGKGYSQFTSLA 372

  Fly   393 THYKSKHHRLKVEEQ 407
                 :|.|....||
Human   373 -----EHQRFHTGEQ 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17806	NP_650658.1	zf-AD	4..76	CDD:285071	5/23 (22%)
		zf-C2H2	260..282	CDD:278523	9/21 (43%)
		C2H2 Zn finger	262..282	CDD:275368	8/19 (42%)
		C2H2 Zn finger	290..311	CDD:275368	6/20 (30%)
		COG5048	<298..>383	CDD:227381	31/84 (37%)
		C2H2 Zn finger	319..339	CDD:275368	8/19 (42%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		ZnF_U1	375..407	CDD:197732	7/31 (23%)
		C2H2 Zn finger	378..396	CDD:275368	4/17 (24%)
ZNF354C	NP_055409.1	KRAB	12..72	CDD:214630	11/59 (19%)
		KRAB	12..51	CDD:279668	6/38 (16%)
		C2H2 Zn finger	194..210	CDD:275368	1/15 (7%)
		C2H2 Zn finger	218..238	CDD:275368	4/19 (21%)
		zf-H2C2_2	230..255	CDD:290200	8/24 (33%)
		COG5048	242..>541	CDD:227381	52/150 (35%)
		C2H2 Zn finger	246..266	CDD:275368	8/19 (42%)
		zf-H2C2_2	258..283	CDD:290200	8/24 (33%)
		C2H2 Zn finger	274..294	CDD:275368	6/20 (30%)
		zf-H2C2_2	287..311	CDD:290200	13/24 (54%)
		C2H2 Zn finger	302..322	CDD:275368	8/19 (42%)
		zf-H2C2_2	315..339	CDD:290200	8/26 (31%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	345..367	CDD:290200	8/21 (38%)
		C2H2 Zn finger	358..378	CDD:275368	6/24 (25%)
		C2H2 Zn finger	386..406	CDD:275368
		zf-H2C2_2	399..423	CDD:290200
		C2H2 Zn finger	414..434	CDD:275368
		C2H2 Zn finger	442..462	CDD:275368
		zf-H2C2_2	454..479	CDD:290200
		C2H2 Zn finger	470..490	CDD:275368
		zf-H2C2_2	483..507	CDD:290200
		C2H2 Zn finger	498..518	CDD:275368
		C2H2 Zn finger	526..544	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050