DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17806 and ZNF547

DIOPT Version :9

Sequence 1:	NP_650658.1	Gene:	CG17806 / 42142	FlyBaseID:	FBgn0038548	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_775902.2	Gene:	ZNF547 / 284306	HGNCID:	26432	Length:	402	Species:	Homo sapiens

Alignment Length:	263	Identity:	73/263 - (27%)
Similarity:	104/263 - (39%)	Gaps:	62/263 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 IGEVQKNRRKPRSKGCL--------EECPG--KDMAKIENIDST----------TNKTKEEKYAT 242
            :|..|....||    ||        |.|..  ||:.::...|.|          .:..:.:|...
Human    69 VGVSQVMAPKP----CLSTQNTQPCETCSSLLKDILRLAEHDGTHPEQGLYTCPAHLHQHQKEQI 129

  Fly   243 RNKWG---AAKRAYALEHRL------YFCDQCGKTFSEKGNFNVHLRRHKGTKEFQCQECDRMEF 298
            |.|..   ..:..:...||:      :.|.:|||.||.|...:.|.:.|.|.:.::|.:|..:..
Human   130 REKLSRGDGGRPTFVKNHRVHMAGKTFLCSECGKAFSHKHKLSDHQKIHTGERTYKCSKCGILFM 194

  Fly   299 TQHLLNLHVRIKHRGELPYVCKYCGKRFDNCLKRL-NHERNHKESPVHRPHVCSTCQKAFKTSTA 362
            .:..||.|.| .|.||.||.|..|||.| .|...| .|:..|..   .||:.||.|.|.|..|:.
Human   195 ERSTLNRHQR-THTGERPYECNECGKAF-LCKSHLVRHQTIHSG---ERPYECSECGKLFMWSST 254

  Fly   363 LKDHIVVHTGEQPFHCELCQTFFNRRNALATHYK-----------------------SKHHRLKV 404
            |..|..||||::|:.|..|..||...:.|..||:                       |:|.|:..
Human   255 LITHQRVHTGKRPYGCSECGKFFKCNSNLFRHYRIHTGKRSYGCSECGKFFMERSTLSRHQRVHT 319

  Fly   405 EEQ 407
            .|:
Human   320 GER 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17806	NP_650658.1	zf-AD	4..76	CDD:285071
		zf-C2H2	260..282	CDD:278523	8/21 (38%)
		C2H2 Zn finger	262..282	CDD:275368	8/19 (42%)
		C2H2 Zn finger	290..311	CDD:275368	6/20 (30%)
		COG5048	<298..>383	CDD:227381	35/85 (41%)
		C2H2 Zn finger	319..339	CDD:275368	8/20 (40%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		ZnF_U1	375..407	CDD:197732	11/54 (20%)
		C2H2 Zn finger	378..396	CDD:275368	6/17 (35%)
ZNF547	NP_775902.2	KRAB	11..66	CDD:214630
		KRAB	11..50	CDD:279668
		COG5048	<156..314	CDD:227381	53/162 (33%)
		C2H2 Zn finger	158..178	CDD:275368	8/19 (42%)
		C2H2 Zn finger	186..206	CDD:275368	6/20 (30%)
		zf-H2C2_2	199..221	CDD:290200	13/22 (59%)
		C2H2 Zn finger	214..234	CDD:275368	8/20 (40%)
		zf-H2C2_2	226..249	CDD:290200	9/25 (36%)
		C2H2 Zn finger	242..262	CDD:275368	8/19 (42%)
		C2H2 Zn finger	270..290	CDD:275368	7/19 (37%)
		C2H2 Zn finger	298..318	CDD:275368	3/19 (16%)
		zf-H2C2_2	311..334	CDD:290200	4/12 (33%)
		C2H2 Zn finger	326..346	CDD:275368
		zf-H2C2_2	339..363	CDD:290200
		C2H2 Zn finger	354..374	CDD:275368
		C2H2 Zn finger	380..400	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960