DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17806 and ZNF396

DIOPT Version :9

Sequence 1:	NP_650658.1	Gene:	CG17806 / 42142	FlyBaseID:	FBgn0038548	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001309215.1	Gene:	ZNF396 / 252884	HGNCID:	18824	Length:	335	Species:	Homo sapiens

Alignment Length:	363	Identity:	78/363 - (21%)
Similarity:	136/363 - (37%)	Gaps:	84/363 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RTCGQEAE-HAKSLFDKEA----------------RDVLSNILKLTGFWLRNQPGVPTRICLSCL 53
            :||..::. |..|.:..|.                .:.||.:.:|...|||  |.|.|:..:..|
Human    32 QTCDPDSSLHWSSSYSPETFRQQFRQFGYQDSPGPHEALSRLWELCHLWLR--PEVHTKEQILEL 94

  Fly    54 LDLNDAIAFRERCIRTNSSWFEKQGKQEDSDTETAREGGNNRLESRVDVMPISIAQPQRRRILPQ 118
            |.|...:|...:.::   :|.:|...:...:|.|..|.....|:.     |..|...:|:
Human    95 LVLEQFLAILPKELQ---AWVQKHHPENGEETVTMLEDVERELDG-----PKQIFFGRRK----- 146

  Fly   119 RSKKVDGVPLKTVETPIYPLVVPEIPPADLVDPLRCEDPIQVKSEPQLSSDYPVESMNHEEPASE 183
                              .::..::.|:::.:.|.....:.||.:.| .:.:.::|:...:
Human   147 ------------------DMIAEKLAPSEITEELPSSQLMPVKKQLQ-GASWELQSLRPHD---- 188

  Fly   184 MPQVMKEEPRTLQVIGEVQKNRRKPRSKGCLEECPGKDMAKIENIDSTTNK-TKE-----EKYAT 242
                  |:.:|.    .|:...|:..|.|....|...::..:....|:|.: |.|     ||...
Human   189 ------EDIKTT----NVKSASRQKTSLGIELHCNVSNILHMNGSQSSTYRGTYEQDGRFEKRQG 243

  Fly   243 RNKWGAAKRAYALEHRLYFCDQCGKTFSEKGNFNVHLRRHKGTKEFQCQECDRMEFTQHLLNLHV 307
            ...|...::          ||:|||.||:.....:|.|.|.|.|.:.|.||.: .|::..:.:..
Human   244 NPSWKKQQK----------CDECGKIFSQSSALILHQRIHSGKKPYACDECAK-AFSRSAILIQH 297

  Fly   308 RIKHRGELPYVCKYCGKRFDNCLKRLNHERNH--KESP 343
            |..|.||.||.|..|||.|........|.:.|  |:.|
Human   298 RRTHTGEKPYKCHDCGKAFSQSSNLFRHRKRHIRKKVP 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17806	NP_650658.1	zf-AD	4..76	CDD:285071	19/86 (22%)
		zf-C2H2	260..282	CDD:278523	9/21 (43%)
		C2H2 Zn finger	262..282	CDD:275368	9/19 (47%)
		C2H2 Zn finger	290..311	CDD:275368	5/20 (25%)
		COG5048	<298..>383	CDD:227381	16/48 (33%)
		C2H2 Zn finger	319..339	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..370	CDD:275368
		ZnF_U1	375..407	CDD:197732
		C2H2 Zn finger	378..396	CDD:275368
ZNF396	NP_001309215.1	SCAN	48..157	CDD:128708	24/141 (17%)
		SCAN	48..136	CDD:280241	20/92 (22%)
		COG5048	239..>306	CDD:227381	23/77 (30%)
		zf-C2H2	252..273	CDD:278523	9/30 (30%)
		C2H2 Zn finger	253..273	CDD:275368	9/19 (47%)
		zf-H2C2_2	269..290	CDD:290200	9/21 (43%)
		C2H2 Zn finger	281..301	CDD:275368	5/20 (25%)
		zf-H2C2_2	294..318	CDD:290200	11/23 (48%)
		C2H2 Zn finger	309..329	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050