DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17806 and ZNF281

DIOPT Version :9

Sequence 1:	NP_650658.1	Gene:	CG17806 / 42142	FlyBaseID:	FBgn0038548	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001268222.1	Gene:	ZNF281 / 23528	HGNCID:	13075	Length:	895	Species:	Homo sapiens

Alignment Length:	246	Identity:	57/246 - (23%)
Similarity:	95/246 - (38%)	Gaps:	68/246 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 EDPIQVKSEPQLSSDYPVESMNH--EEPASEMPQVMKEEPRTLQVIGEVQKNRR-KPRSKGCLEE 216
            :.|.|...:..|||....:. :|  |||..:.               .|:|.:| ||.|:|
Human   186 QQPAQHHRDVLLSSSSRTDD-HHGTEEPKQDT---------------NVKKAKRPKPESQG---- 230

  Fly   217 CPGKDMAKIENIDSTTNKTKEEKYATRNKWGAAKRAYALEHRLYFCDQCGKTFSEKGNFNVHLRR 281
                  .|.:...|.::|..    ...:..||   ..:...:.:.||.|...|....:...|:..
Human   231 ------IKAKRKPSASSKPS----LVGDGEGA---ILSPSQKPHICDHCSAAFRSSYHLRRHVLI 282

  Fly   282 HKGTKEFQCQECDRMEFTQHLLNLHVRIKHRGELPYVCKYCGKRFDNCLKRLNHERNHKESPVHR 346
            |.|.:.|||.:|......::||..|.:| |..|.|:.|..|..:|   :::.:.|| ||.:
Human   283 HTGERPFQCSQCSMGFIQKYLLQRHEKI-HSREKPFGCDQCSMKF---IQKYHMER-HKRT---- 338

  Fly   347 PHVCSTCQKAFKTSTALKDHIVVHTGEQPFHCELCQTFFNRRNALATHYKS 397
                                   |:||:|:.|:.||.:|:|.:.|..|.::
Human   339 -----------------------HSGEKPYKCDTCQQYFSRTDRLLKHRRT 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17806	NP_650658.1	zf-AD	4..76	CDD:285071
		zf-C2H2	260..282	CDD:278523	5/21 (24%)
		C2H2 Zn finger	262..282	CDD:275368	5/19 (26%)
		C2H2 Zn finger	290..311	CDD:275368	6/20 (30%)
		COG5048	<298..>383	CDD:227381	20/84 (24%)
		C2H2 Zn finger	319..339	CDD:275368	5/19 (26%)
		C2H2 Zn finger	350..370	CDD:275368	0/19 (0%)
		ZnF_U1	375..407	CDD:197732	8/23 (35%)
		C2H2 Zn finger	378..396	CDD:275368	7/17 (41%)
ZNF281	NP_001268222.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..113
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..149
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..253		21/99 (21%)
		C2H2 Zn finger	263..283	CDD:275368	5/19 (26%)
		zf-H2C2_2	275..300	CDD:316026	7/24 (29%)
		C2H2 Zn finger	291..311	CDD:275368	6/20 (30%)
		zf-H2C2_2	304..328	CDD:316026	9/27 (33%)
		C2H2 Zn finger	319..339	CDD:275368	7/50 (14%)
		zf-H2C2_2	331..356	CDD:316026	12/52 (23%)
		C2H2 Zn finger	347..366	CDD:275368	7/18 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..427
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..660
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	778..817
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910