DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG17806 and ZNF554

DIOPT Version :9

Sequence 1:NP_650658.1 Gene:CG17806 / 42142 FlyBaseID:FBgn0038548 Length:421 Species:Drosophila melanogaster
Sequence 2:NP_001096121.1 Gene:ZNF554 / 115196 HGNCID:26629 Length:538 Species:Homo sapiens


Alignment Length:358 Identity:92/358 - (25%)
Similarity:131/358 - (36%) Gaps:127/358 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   158 IQVKSEPQLS-SDYPVESMN----------HEEPAS---------------------EMPQVMKE 190
            |:.|..||.| ||:.....|          .|||||                     |.||.:..
Human   137 IEEKGTPQASCSDWMTVLRNQDSTYKKVALQEEPASGINMIKLIREDGGWKQLEDSHEDPQGLLS 201

  Fly   191 EPRTLQVIGEVQKNR------------------RKPRSKG---CLEECPGKDMAKIENIDSTTNK 234
            :..:|.|:...|:..                  .:..|||   |..|.....:|.    ||..|.
Human   202 QKASLHVVAVPQEKATAWHGFGENGNLSPALVLSQGSSKGNHLCGSELDITSLAS----DSVLNH 262

  Fly   235 TKEEKYATR-----NKWGAAKR--AYALEH------------------------------RLYFC 262
             .:..||.|     |:.|.|.|  ::.::|                              :.:.|
Human   263 -HQLGYADRRPCESNECGNAIRQNSHFIQHGGKMFVYLENGQSLNHGMALTIHNKINTAEKPFEC 326

  Fly   263 DQCGKTFSEKGNFNVHLRRHKGTKEFQCQECDR-----MEFTQHL-------------------- 302
            .||||.|:.:.:.:.|.|.|.|.|.::||||.|     ...|:||                    
Human   327 HQCGKVFNRRHSLSEHQRIHTGEKPYECQECGRAFTHSSTLTRHLRTHTGEKPYGCGECGKAFNR 391

  Fly   303 ---LNLHVRIKHRGELPYVCKYCGKRFDNCLKRLNHERNHKESPVHRPHVCSTCQKAFKTSTALK 364
               |..|.|| |.||.||.|:.|||.|......:.|:|.|..   .:|:.||.|.|||...::|.
Human   392 ISSLTQHQRI-HTGEKPYKCEDCGKSFCQSSYLILHKRTHTG---EKPYECSECGKAFSDRSSLN 452

  Fly   365 DHIVVHTGEQPFHCELCQTFFNRRNALATHYKS 397
            .|...||||.|:.|:.|...|::|::|..|.::
Human   453 QHERTHTGENPYECKQCGRAFSQRSSLVRHERT 485

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17806NP_650658.1 zf-AD 4..76 CDD:285071
zf-C2H2 260..282 CDD:278523 8/21 (38%)
C2H2 Zn finger 262..282 CDD:275368 8/19 (42%)
C2H2 Zn finger 290..311 CDD:275368 12/48 (25%)
COG5048 <298..>383 CDD:227381 36/107 (34%)
C2H2 Zn finger 319..339 CDD:275368 7/19 (37%)
C2H2 Zn finger 350..370 CDD:275368 8/19 (42%)
ZnF_U1 375..407 CDD:197732 7/23 (30%)
C2H2 Zn finger 378..396 CDD:275368 6/17 (35%)
ZNF554NP_001096121.1 KRAB 44..84 CDD:307490
COG5048 <225..417 CDD:227381 49/197 (25%)
C2H2 Zn finger 276..291 CDD:275368 4/14 (29%)
C2H2 Zn finger 293..318 CDD:275368 0/24 (0%)
zf-C2H2 324..346 CDD:306579 8/21 (38%)
C2H2 Zn finger 326..346 CDD:275368 8/19 (42%)
COG5048 <350..532 CDD:227381 46/140 (33%)
C2H2 Zn finger 354..374 CDD:275368 8/19 (42%)
C2H2 Zn finger 382..402 CDD:275368 4/20 (20%)
C2H2 Zn finger 410..430 CDD:275368 7/19 (37%)
C2H2 Zn finger 438..458 CDD:275368 8/19 (42%)
C2H2 Zn finger 466..486 CDD:275368 6/20 (30%)
C2H2 Zn finger 494..514 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 123 1.000 Inparanoid score I4733
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.050

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