DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG17806 and ZNF274

DIOPT Version :9

Sequence 1:NP_650658.1 Gene:CG17806 / 42142 FlyBaseID:FBgn0038548 Length:421 Species:Drosophila melanogaster
Sequence 2:NP_598009.1 Gene:ZNF274 / 10782 HGNCID:13068 Length:653 Species:Homo sapiens


Alignment Length:505 Identity:118/505 - (23%)
Similarity:184/505 - (36%) Gaps:146/505 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 RDVLSNILKLTGFWLRNQPGVPTRICLSCLLDLNDAIAFRERCIRTNSSWFEKQGKQEDSDTETA 88
            |:.|..:.:|...||  ||...::..:..||.|...:......:||   |.|.|..:...:....
Human   176 REALDQLRELCHQWL--QPKARSKEQILELLVLEQFLGALPVKLRT---WVESQHPENCQEVVAL 235

  Fly    89 REGGNNRLESRVDVMPISIAQPQR-----RRILPQRSKKVDGVPLKTVETPIYPL-VVPEIPPA- 146
            .||..  ..|..:|:|  ..||..     ..:..|:.:|.:       :..|.|: |:||.|.. 
Human   236 VEGVT--WMSEEEVLP--AGQPAEGTTCCLEVTAQQEEKQE-------DAAICPVTVLPEEPVTF 289

  Fly   147 -DL-VDPLRCEDPIQVKSEPQLSSDYPVESMNH------------EE--PASEMPQVMKEEPR-- 193
             |: ||..|.|..:...::.....|..:|:..|            :|  |.|::|:   |||.  
Human   290 QDVAVDFSREEWGLLGPTQRTEYRDVMLETFGHLVSVGWETTLENKELAPNSDIPE---EEPAPS 351

  Fly   194 ------------------TLQVIGEVQK------------------------NRRKPRSKGCLEE 216
                              |||  |.||:                        ||....:.|.| :
Human   352 LKVQESSRDCALSSTLEDTLQ--GGVQEVQDTVLKQMESAQEKDLPQKKHFDNRESQANSGAL-D 413

  Fly   217 CPGKDMAKIENIDSTTN-------------------------KTKEEKYATRNKW---------- 246
            .....:.||:|.:|..|                         :.|..|:.:|.|.          
Human   414 TNQVSLQKIDNPESQANSGALDTNQVLLHKIPPRKRLRKRDSQVKSMKHNSRVKIHQKSCERQKA 478

  Fly   247 ----GAAKRAYALEHRLYF-----------CDQCGKTFSEKGNFNVHLRRHKGTKEFQCQECDRM 296
                |..|.......::.|           |.:|||.|.....|:||.:.|.|.:.:.||:|.:.
Human   479 KEGNGCRKTFSRSTKQITFIRIHKGSQVCRCSECGKIFRNPRYFSVHKKIHTGERPYVCQDCGKG 543

  Fly   297 EFTQHLLNLHVRIKHRGELPYVCKYCGKRFDNCLKRLNHERNHKESPVHRPHVCSTCQKAFKTST 361
            ......|..|.|: |.||.|:.|:.||:.|::......|.|.|..:   :|:.|..|.|||:.|:
Human   544 FVQSSSLTQHQRV-HSGERPFECQECGRTFNDRSAISQHLRTHTGA---KPYKCQDCGKAFRQSS 604

  Fly   362 ALKDHIVVHTGEQPFHCELCQTFFNRRNALATHYKSKHHRLKVEEQSKMP 411
            .|..|...||||:|:.|..|...|.:.:.|..|.:: |:|.|  .:.|.|
Human   605 HLIRHQRTHTGERPYACNKCGKAFTQSSHLIGHQRT-HNRTK--RKKKQP 651

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG17806NP_650658.1 zf-AD 4..76 CDD:285071 13/51 (25%)
zf-C2H2 260..282 CDD:278523 9/32 (28%)
C2H2 Zn finger 262..282 CDD:275368 8/19 (42%)
C2H2 Zn finger 290..311 CDD:275368 6/20 (30%)
COG5048 <298..>383 CDD:227381 30/84 (36%)
C2H2 Zn finger 319..339 CDD:275368 6/19 (32%)
C2H2 Zn finger 350..370 CDD:275368 8/19 (42%)
ZnF_U1 375..407 CDD:197732 9/31 (29%)
C2H2 Zn finger 378..396 CDD:275368 5/17 (29%)
ZNF274NP_598009.1 KRAB 14..73 CDD:214630
KRAB 14..53 CDD:279668
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 139..159
SCAN 157..269 CDD:128708 23/101 (23%)
SCAN 157..245 CDD:280241 18/75 (24%)
KRAB 287..>327 CDD:214630 8/39 (21%)
KRAB 287..326 CDD:279668 8/38 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 339..359 6/22 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..414 4/26 (15%)
COG5048 <389..644 CDD:227381 63/260 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 448..485 5/36 (14%)
C2H2 Zn finger 481..501 CDD:275368 3/19 (16%)
C2H2 Zn finger 509..529 CDD:275368 8/19 (42%)
zf-H2C2_2 521..546 CDD:290200 8/24 (33%)
C2H2 Zn finger 537..557 CDD:275368 6/20 (30%)
zf-H2C2_2 549..573 CDD:290200 10/24 (42%)
zf-C2H2 563..585 CDD:278523 6/21 (29%)
C2H2 Zn finger 565..585 CDD:275368 6/19 (32%)
zf-C2H2 591..613 CDD:278523 8/21 (38%)
C2H2 Zn finger 593..613 CDD:275368 8/19 (42%)
zf-H2C2_2 605..630 CDD:290200 10/24 (42%)
C2H2 Zn finger 621..641 CDD:275368 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 632..653 7/23 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 123 1.000 Inparanoid score I4733
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.960

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