DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17803 and si:dkey-262g12.10

DIOPT Version :9

Sequence 1:	NP_001303488.1	Gene:	CG17803 / 42141	FlyBaseID:	FBgn0038547	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_021331488.1	Gene:	si:dkey-262g12.10 / 798256	ZFINID:	ZDB-GENE-161017-33	Length:	322	Species:	Danio rerio

Alignment Length:	354	Identity:	88/354 - (24%)
Similarity:	133/354 - (37%)	Gaps:	83/354 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 DSEGVLDEDDFPLDAEPTQFSLSEDELDLDRDTEKDFALEQNKSCNEIISIRKCKTKEEIGKVDH 270
            :||.::.||.|.:..|           |.:..||.....|:....||        |:|.|...:|
Zfish    29 ESEDLIIEDTFTVKHE-----------DPEEQTELMLRKEETPGLNE--------TEENIQNEEH 74

  Fly   271 GAKVYKVVLGEYNSLKETAPKYSLSLPKKPQLRVSPEEKNRRRRERIQAKPLNYVCDKCGHTFRQ 335
                                         ..|..:.:....:::.:...   |:.|.:||.:|.|
Zfish    75 -----------------------------RDLMAAEQSTVAKKKSKSNG---NFPCSECGKSFTQ 107

  Fly   336 RSQLQMHLLRHNRAKNFECPECPKKFYDLYTRNIHVRALHKGEHPFPCNHCNESFANASSRHRHE 400
            :..|.:|:..|...|.:.|.:|.|:|..|:...:|.: ||.||.|:.|..|...|..     :..
Zfish   108 KHNLVIHMSIHTGEKPYACQQCGKRFRLLHILQLHFK-LHTGERPYACTQCGMRFIK-----KQR 166

  Fly   401 RDVHGAGNRIRTRVKSKEEGSSRHYCTQCTKSYTSKKGLVLHMNFHNGSRPFQCKICQMKFADPS 465
            .|.|.|       |.|.|:   ...|.||.|.:..|..|..||..|.|.:||.|::|...|:...
Zfish   167 LDTHMA-------VHSTEK---PFVCQQCGKCFAQKHNLKQHMKIHTGEKPFACQLCGKSFSQKQ 221

  Fly   466 AMKRHQALH-DKFPIRCDICLKGFLLRSQLTKHQDVHTGMHPHRCEICDVHYRHRYNLNKHKNTD 529
            .:..|..:| .:.|..|..|.|.|..|:.|..|...|||..|:.|..|...:.::|.||.|..|.
Zfish   222 RLAVHTMIHTGERPYTCAQCGKSFTQRNNLNYHMKFHTGDKPYICTECGKSFTYKYYLNAHMRTH 286

  Fly   530 ---------------LHRDNMQKAIKEEV 543
                           .||.|:.:.:|..|
Zfish   287 TRERPFICGQCGKSYCHRGNLSQHLKLHV 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17803	NP_001303488.1	zf-AD	86..160	CDD:214871
		COG5048	<323..528	CDD:227381	65/205 (32%)
		zf-C2H2	324..346	CDD:278523	7/21 (33%)
		C2H2 Zn finger	326..346	CDD:275368	7/19 (37%)
		C2H2 Zn finger	354..375	CDD:275368	6/20 (30%)
		C2H2 Zn finger	383..401	CDD:275368	3/17 (18%)
		C2H2 Zn finger	426..446	CDD:275368	8/19 (42%)
		C2H2 Zn finger	454..474	CDD:275368	4/19 (21%)
		C2H2 Zn finger	481..501	CDD:275368	7/19 (37%)
		C2H2 Zn finger	509..528	CDD:275368	6/18 (33%)
si:dkey-262g12.10	XP_021331488.1	COG5048	82..>147	CDD:227381	17/68 (25%)
		C2H2 Zn finger	98..118	CDD:275368	7/19 (37%)
		zf-H2C2_2	110..134	CDD:316026	7/23 (30%)
		C2H2 Zn finger	126..146	CDD:275368	6/20 (30%)
		COG5048	<151..300	CDD:227381	46/163 (28%)
		C2H2 Zn finger	154..174	CDD:275368	6/31 (19%)
		C2H2 Zn finger	182..202	CDD:275368	8/19 (42%)
		C2H2 Zn finger	210..230	CDD:275368	4/19 (21%)
		C2H2 Zn finger	238..258	CDD:275368	7/19 (37%)
		C2H2 Zn finger	266..286	CDD:275368	6/19 (32%)
		C2H2 Zn finger	294..314	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910