DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17803 and ZNF99

DIOPT Version :9

Sequence 1:	NP_001303488.1	Gene:	CG17803 / 42141	FlyBaseID:	FBgn0038547	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001073878.2	Gene:	ZNF99 / 7652	HGNCID:	13175	Length:	864	Species:	Homo sapiens

Alignment Length:	494	Identity:	111/494 - (22%)
Similarity:	191/494 - (38%)	Gaps:	117/494 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 TGLQECDPPPASKCRTCFRI------ISRH------------EDAQDLYDRVNIALLHHIKVITG 119
            ||.:.|      ||..|.::      :.:|            |:....: :.:..|..|..:.||
Human   252 TGKKPC------KCEECGKVFNNSSTLMKHKIIHTGKKPYKCEECGKAF-KQSSHLTRHKAIHTG 309

  Fly   120 VWIQQGVKELPHHICSTCQETVNKSMEFRA-----------KCQQVDKKLRQ--TTEKYNIQICD 171
                    |.|:. |..|.:..|.....|.           ||::..|...|  |..|:.|
Human   310 --------EKPYK-CEECGKAFNHFSALRKHQIIHTGKKPYKCEECGKAFSQSSTLRKHEI---- 361

  Fly   172 EEMESELENVLYEESAQQAKGVVGLEDFSSELLPDSEGVLDEDDFPLDAEPTQFSLSEDELDLDR 236
              :.:|.:...|||..:....:..|.         ...::.....|...|
Human   362 --IHTEEKPYKYEECGKAFSNLSALR---------KHEIIHTGQKPYKCE--------------- 400

  Fly   237 DTEKDFALEQNKSCNEIISIRKCKTKEEIGKVDHGAKVYKVVLGEYNSLKETAPKYSLSLPKKPQ 301
            :..|.|......:.:::|     .|.|:..|.:...|.:|    .:::|::....::...|.|
Human   401 ECGKAFKWSSKLTVHKVI-----HTAEKPCKCEECGKAFK----RFSALRKHKIIHTGKQPYK-- 454

  Fly   302 LRVSPEEKNR--------RRRERIQAKPLNYVCDKCGHTFRQRSQLQMHLLRHNRAKNFECPECP 358
                .||.::        |:.|.|......|.|::||..|:..|:|.:|.:.|...|..:|.||.
Human   455 ----CEECSKAFSNFSALRKHEIIHTGEKPYKCEECGKAFKWSSKLTVHKVIHMEEKPCKCEECG 515

  Fly   359 KKFYDLYTRNIHVRALHKGEHPFPCNHCNESFANASSRHRHERDVHGAGNRIRTRVKSKEEGSSR 423
            |.|........| :.:|.|:.|:.|..|.::|.|:|:..:| :.:|              .|...
Human   516 KAFKHFSALRKH-KIIHTGKKPYKCEECGKAFNNSSTLMKH-KIIH--------------TGKKP 564

  Fly   424 HYCTQCTKSYTSKKGLVLHMNFHNGSRPFQCKICQMKFADPSAMKRHQALH-DKFPIRCDICLKG 487
            :.|.:|.|::.....|..|...|.|.:|::|:.|...|...||:::||.:| .|.|.:|:.|.|.
Human   565 YKCEECGKAFKQSSHLTRHKAIHTGEKPYKCEECGKAFNHFSALRKHQIIHTGKKPYKCEECGKA 629

  Fly   488 FLLRSQLTKHQDVHTGMHPHRCEICDVHYRHRYNLNKHK 526
            |...|.|.||:.:|||..|::||.|...::...:|.:||
Human   630 FSQSSTLRKHEIIHTGEKPYKCEECGKAFKWSSHLTRHK 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17803	NP_001303488.1	zf-AD	86..160	CDD:214871	17/102 (17%)
		COG5048	<323..528	CDD:227381	63/205 (31%)
		zf-C2H2	324..346	CDD:278523	8/21 (38%)
		C2H2 Zn finger	326..346	CDD:275368	7/19 (37%)
		C2H2 Zn finger	354..375	CDD:275368	6/20 (30%)
		C2H2 Zn finger	383..401	CDD:275368	6/17 (35%)
		C2H2 Zn finger	426..446	CDD:275368	5/19 (26%)
		C2H2 Zn finger	454..474	CDD:275368	7/19 (37%)
		C2H2 Zn finger	481..501	CDD:275368	8/19 (42%)
		C2H2 Zn finger	509..528	CDD:275368	6/18 (33%)
ZNF99	NP_001073878.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	147..167	CDD:275368
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		C2H2 Zn finger	232..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368	3/19 (16%)
		COG5048	267..684	CDD:227381	105/473 (22%)
		zf-H2C2_2	272..296	CDD:290200	2/24 (8%)
		C2H2 Zn finger	287..307	CDD:275368	3/20 (15%)
		zf-H2C2_2	299..324	CDD:290200	8/33 (24%)
		C2H2 Zn finger	315..335	CDD:275368	4/19 (21%)
		zf-H2C2_2	327..352	CDD:290200	4/24 (17%)
		C2H2 Zn finger	343..363	CDD:275368	6/25 (24%)
		C2H2 Zn finger	371..391	CDD:275368	4/28 (14%)
		zf-H2C2_2	383..407	CDD:290200	4/47 (9%)
		C2H2 Zn finger	399..419	CDD:275368	4/39 (10%)
		C2H2 Zn finger	427..447	CDD:275368	3/23 (13%)
		C2H2 Zn finger	455..475	CDD:275368	4/19 (21%)
		zf-H2C2_2	467..491	CDD:290200	7/23 (30%)
		C2H2 Zn finger	483..503	CDD:275368	7/19 (37%)
		C2H2 Zn finger	511..531	CDD:275368	6/20 (30%)
		zf-H2C2_2	523..548	CDD:290200	7/25 (28%)
		COG5048	534..857	CDD:227381	45/150 (30%)
		C2H2 Zn finger	539..559	CDD:275368	6/20 (30%)
		zf-H2C2_2	552..576	CDD:290200	6/38 (16%)
		C2H2 Zn finger	567..587	CDD:275368	5/19 (26%)
		zf-H2C2_2	579..604	CDD:290200	8/24 (33%)
		C2H2 Zn finger	595..615	CDD:275368	7/19 (37%)
		zf-H2C2_2	607..632	CDD:290200	10/24 (42%)
		C2H2 Zn finger	623..643	CDD:275368	8/19 (42%)
		zf-H2C2_2	636..659	CDD:290200	10/22 (45%)
		C2H2 Zn finger	651..671	CDD:275368	6/18 (33%)
		zf-H2C2_2	663..688	CDD:290200	3/6 (50%)
		C2H2 Zn finger	679..699	CDD:275368
		zf-H2C2_2	691..716	CDD:290200
		C2H2 Zn finger	707..727	CDD:275368
		zf-H2C2_2	720..743	CDD:290200
		C2H2 Zn finger	735..755	CDD:275368
		C2H2 Zn finger	763..783	CDD:275368
		zf-H2C2_2	775..800	CDD:290200
		C2H2 Zn finger	791..811	CDD:275368
		C2H2 Zn finger	819..839	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142244
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840