Protein Alignment CG17803 and topi

DIOPT Version :10

• Sequence 1: NP_650657.2
• Gene: CG17803 / 42141
• FlyBaseID: FBgn0038547
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_649945.1
• Gene: topi / 41199
• FlyBaseID: FBgn0037751
• Length: 814
• Species: Drosophila melanogaster
• Alignment Length: 697
• Identity: 133/697 - (19%)
• Similarity: 226/697 - (32%)
• Gaps: 186/697 - (26%)

  Fly    19 NKDTMRSSRQVNKKLVKLFLAEADDSDATCTTSTALDTTTADSAFFDSDFEEESTGLQECDPP-- 81
            |:.|....|.|:.:.:..|.|..........|...::.|.||.||  ....:|:.|.:..||.
  Fly    37 NESTGGLERIVSHEELSRFFAVGPAGALPMPTDVVVERTLADPAF--KQILQEADGKKGFDPQAE 99

  Fly    82 -----------PASKCRTCFRII--SRHEDAQDLYDRVN----------IALLHHIKVITGVWIQ 123
                       .:||..|...:.  ||...:....:|:.          :|..:|......:.:.
  Fly   100 QMKIRDFLAGVTSSKMTTEQSVFHGSRSNSSASTVNRIKCPTCLVQFDAVAFQNHSCEAKPIEVA 164

  Fly   124 QGVKELPHHICSTCQETVNKSMEFRAKCQQVDKKLRQTTEKYNIQICDEEMESELENVLYEESAQ 188
            ...:|.||.:.:........|   :...::|.::.:....:|    ..:||:.:|...:......
  Fly   165 VPQQEKPHLVPTVSAPPAPLS---KPASERVIRENQVRLRRY----IKDEMKYDLATGIESSRKN 222

  Fly   189 QAKGVVGLEDFSSELLPDSEGVLDEDDFPLDAEPTQFSLSEDELDLDRDTEKDFALEQNKSCNEI 253
            .|||.........:.:..|..|...:...||..|:|.|            |:...:.. ...:.:
  Fly   223 AAKGPNECTMCDRKFVHASGLVRHMEKHALDLIPSQTS------------EQPHTIPA-AGLHVV 274

  Fly   254 ISIRKCKTKEEIGKVDHGAKV-YKVVL---GEYNSLKET----APKY-----------SLSLPKK 299
            :....|      |::.:..:| ::..|   .|:::::::    .|..           .:.:...
  Fly   275 VKCNSC------GRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDND 333

  Fly   300 PQLRVSPEEKNRRRRERIQAKPLNYV--CDKCGHTFRQRSQLQMHLLRHNRAKNFECPECPKKFY 362
            |....|.:..|..::|...:..|..|  |:.|.:.|...::|.:|...|...:.|||..|..:..
  Fly   334 PAFATSNQNTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMN 398

  Fly   363 DLYTRNIH-----------VRALHKG-EHPFPCNHCNESFANAS--SRHR--------------- 398
            .....:||           :|:|:.. ...|.||.|...|||..  ..||
  Fly   399 TAKEASIHFQTDCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGK 463

  Fly   399 ----------------HERDVHGAGNRIRTRVKSKE-----EGSSRHY-CTQCTKSYTSKKGLVL 441
                            |:...|.....:..:.:.||     .|..|.| |..|.||||....|..
  Fly   464 KLLLPCDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQ 528

  Fly   442 HMNFHNGSRPFQCK-------------------------------ICQMKFADPSAMKRHQALH- 474
            |:.||.|.:||.|:                               :|..:|...|...:|:.:|
  Fly   529 HLRFHQGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHR 593

  Fly   475 DKFPIRCDICLKGFLLRSQLTKHQDVHTGMHPHRCEICDVHYRHRYNLNKH-KNTDLHRD----- 533
            .:....|:.|.|.|.....|..||.:|||..|:.|..|...:|.|.:.:|| :....|.|
  Fly   594 GERRYECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRL 658

  Fly   534 --NMQKAIKEEVNGLQQAFKDIDKEMDFESQTPMQPNAQEVRARTQD 578
              .|||                     |:.:|.....||......||
  Fly   659 MMQMQK---------------------FQLETAAAQKAQSHNPEQQD 684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17803	NP_650657.2	zf-AD	86..160	CDD:214871	11/85 (13%)
		SUF4-like	320..>376	CDD:411020	16/68 (24%)
		C2H2 Zn finger	323..351	CDD:411020	7/29 (24%)
		C2H2 Zn finger	326..346	CDD:275368	5/19 (26%)
		C2H2 Zn finger	354..375	CDD:411020	5/31 (16%)
		C2H2 Zn finger	354..375	CDD:275368	5/31 (16%)
		C2H2 Zn finger	383..401	CDD:275368	9/50 (18%)
		C2H2 Zn finger	426..446	CDD:275368	8/19 (42%)
		C2H2 Zn finger	454..474	CDD:275368	5/50 (10%)
		C2H2 Zn finger	481..501	CDD:275368	7/19 (37%)
		C2H2 Zn finger	509..528	CDD:275368	6/19 (32%)
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275370	2/19 (11%)
		C2H2 Zn finger	277..297	CDD:275370	4/25 (16%)
		C2H2 Zn finger	431..453	CDD:275368	8/21 (38%)
		COG5048	<450..647	CDD:227381	43/196 (22%)
		C2H2 Zn finger	469..490	CDD:275368	2/20 (10%)
		C2H2 Zn finger	513..564	CDD:275368	14/50 (28%)
		C2H2 Zn finger	541..561	CDD:275368	1/19 (5%)
		C2H2 Zn finger	572..592	CDD:275368	4/19 (21%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	612..637	CDD:463886	9/24 (38%)
		C2H2 Zn finger	628..646	CDD:275368	6/17 (35%)