DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG17803 and CG8944

DIOPT Version :9

Sequence 1:	NP_001303488.1	Gene:	CG17803 / 42141	FlyBaseID:	FBgn0038547	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_573065.1	Gene:	CG8944 / 32517	FlyBaseID:	FBgn0030680	Length:	762	Species:	Drosophila melanogaster

Alignment Length:	674	Identity:	130/674 - (19%)
Similarity:	207/674 - (30%)	Gaps:	273/674 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 HEDAQDLYDRVNIALLHHIKVITGVWIQQGVKELPHHICSTCQETVNKSMEFRAKCQQVDKKLRQ 160
            || .:||.| .:.|||....|     |:|.:::||   ||.......:..:
  Fly    93 HE-IEDLTD-ADTALLEPQMV-----IKQELQDLP---CSDDDVVAGEEDD-------------- 133

  Fly   161 TTEKYNIQICDEE----MESELENVLYEESAQQAKGVVGLEDFSSELLPDSEGVLDEDDFP---- 217
            ..::.|....||:    .||::..|..:..|::........|.|||||...:|....||:.
  Fly   134 DEQRLNDSEADEDEAILPESDVPVVSSKTRARKKVTKQRQRDMSSELLIAGDGDSSMDDYGDPDH 198

  Fly   218 --LDAEPTQFS-------------------LSEDELD----LDRDTEKDFALEQNKSCNEIIS-- 255
              :|....::.                   ||.||:.    |.||.|....::..|....:|.
  Fly   199 SYMDDNSGEYMDFAGFDGVNHSGFGTESDFLSYDEMVEESLLGRDREVTMHIKDRKMIQFLIHSY 263

  Fly   256 ---------------------------IRKCKTKEEIG--------KVDHGAKVYK--------- 276
                                       :.:.|::..|.        |.|:...|||
  Fly   264 QRNPFLWDHGNAQFRDRVKRARFLDWIVLEFKSRFNISLAKDAITRKWDNLRTVYKRECNRMALE 328

  Fly   277 -------------VVLGE---YNS------LKETA--PKYS-----------LSLPKKPQL---R 303
                         ..|.|   ||.      :|||:  .::|           ||:.|:.|.   |
  Fly   329 KTNISTLWYFKELHFLNEVYSYNDKMSDAVVKETSYRRRFSAIWNDTSTAKLLSMVKRYQCFYNR 393

  Fly   304 VSPEEKNRRRR-----------------------ERIQAKPLNYVCDKCGHTFRQR-------SQ 338
            ..|:.:::.||                       :||.....:|...|......:|       :.
  Fly   394 FDPDYRSKERRGEGLHQMAIELQQLIDVTTIQISKRISQLRFDYSKQKMERLNSERLGKKFIANY 458

  Fly   339 L---QMHLLRHNRAKNFECPECPKKFYDLYTRNIHV----RALHKGEHPFPCNHCNESFANASSR 396
            |   |||.: .:....|:|..||:....|...::|:    .:|..|   :.||.|:..|.||...
  Fly   459 LYYDQMHFM-DDDIPPFKCAHCPEIVQTLRELDLHMLTHQPSLGGG---YYCNICSIQFHNAQEF 519

  Fly   397 HRHERDVHGAGNRIRTRVKSKEEGSSRHYCTQCTKSYTSKKGLVLHMNFHN-------------- 447
            ..| :.:|..|   .|.:|..        |..||.|:..|.....|:..||
  Fly   520 DNH-KQLHLGG---VTEIKFN--------CELCTASFREKANYDEHLRRHNEELFLPSLALNHSI 572

  Fly   448 --------------------GSR-------------------------------------PFQCK 455
                                |||                                     |:.|.
  Fly   573 MEGGLGDDEIGVEGEESRGSGSRRKRRHAAKATDDMVDDDDRIGGGGGGGSGGGGTDIAKPYGCD 637

  Fly   456 ICQMKFADPSAMKRHQALHDKFPIRC-----DICLKGFLLRSQLTKHQDVHTGMHPHRCEICDVH 515
            :|:..||.|..:..|:.:|.....||     ..|.|.|:.|:.|.:|...|......:|:||...
  Fly   638 VCRRSFATPGHLNAHRIVHQDERERCYKCDYPQCNKSFVARNSLFEHLKQHYSNEEFKCDICGKT 702

  Fly   516 YRHRYNLNKHKNTDLHRDNMQKAI 539
            ::...||..||  .:| |.:::.:
  Fly   703 FKSTKNLQNHK--QIH-DKIKRYV 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17803	NP_001303488.1	zf-AD	86..160	CDD:214871	15/63 (24%)
		COG5048	<323..528	CDD:227381	61/294 (21%)
		zf-C2H2	324..346	CDD:278523	7/31 (23%)
		C2H2 Zn finger	326..346	CDD:275368	6/29 (21%)
		C2H2 Zn finger	354..375	CDD:275368	5/24 (21%)
		C2H2 Zn finger	383..401	CDD:275368	7/17 (41%)
		C2H2 Zn finger	426..446	CDD:275368	6/19 (32%)
		C2H2 Zn finger	454..474	CDD:275368	6/19 (32%)
		C2H2 Zn finger	481..501	CDD:275368	7/24 (29%)
		C2H2 Zn finger	509..528	CDD:275368	7/18 (39%)
CG8944	NP_573065.1	MADF_DNA_bdg	259..344	CDD:287510	8/84 (10%)
		MADF	379..472	CDD:214738	17/93 (18%)
		C2H2 Zn finger	476..496	CDD:275368	5/19 (26%)
		C2H2 Zn finger	506..526	CDD:275368	7/20 (35%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	636..656	CDD:275368	6/19 (32%)
		zf-C2H2_8	639..712	CDD:292531	20/72 (28%)
		C2H2 Zn finger	666..688	CDD:275368	6/21 (29%)
		zf-C2H2	694..716	CDD:278523	7/23 (30%)
		C2H2 Zn finger	696..716	CDD:275368	7/21 (33%)
		zf-H2C2_2	708..733	CDD:290200	6/19 (32%)
		C2H2 Zn finger	724..744	CDD:275368	130/674 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455486
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930