DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7379 and Ing2

DIOPT Version :9

Sequence 1:	NP_650656.1	Gene:	CG7379 / 42140	FlyBaseID:	FBgn0038546	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_075992.2	Gene:	Ing2 / 69260	MGIID:	1916510	Length:	281	Species:	Mus musculus

Alignment Length:	419	Identity:	110/419 - (26%)
Similarity:	168/419 - (40%)	Gaps:	168/419 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 YVDNYIDSVENLPDDVQRQLSRIRDIDVQYRGLIRDVDHYYDLYLSLQNSADAGRRSRSISRMHQ 81
            ||.:|::.||:||.|:||.:|.:|::|.:|:..::::|..|:.|   :...|:.::.|....:.:
Mouse    28 YVQDYLECVESLPHDMQRNVSVLRELDNKYQETLKEIDDVYEKY---KKEDDSNQKKRLQQHLQR 89

  Fly    82 SLIQAQELGDEKMQIVNHMQEIIDGKLRQLDTDQQNLDLKEDRDR---YALLDDGTPSKLQRLQS 143
            :||.:|||||||:|||..|.|:::.:.||::...|......:.:|   .:.:|...|.:..|  .
Mouse    90 ALINSQELGDEKIQIVTQMLELVENRARQMELHSQCFQDPAESERASDKSKMDSSQPERSSR--R 152

  Fly   144 PMREQGNQAGTGNGGLNGNGLLSAKDLYALGGYAGGVVPGSNAMTSGNGGGSTPNSERSSHVSNG 208
            |.|::.::               ::||                                .|::||
Mouse   153 PRRQRTSE---------------SRDL--------------------------------CHMTNG 170

  Fly   209 GNSGSNGNASGGGGGELQRTGSKRSRRRNESVVNNGSSLEMGGNESNSANEASGSGGGSGERKSS 273
            .:...:           |....|||:
Mouse   171 IDDCDD-----------QPPKEKRSK--------------------------------------- 185

  Fly   274 LGGASGAGQGRKASLQSASGSLASGSAATSSGAAGGGGASGAGVVGGNNSGKKKKRKVRGSGASN 338
                                                             |.|||||       |.
Mouse   186 -------------------------------------------------SAKKKKR-------SK 194

  Fly   339 ANASTREETPPPETIDPDEPTYCVCNQISFGEMILCDNDLCPIEWFHFSCVSLVLKPKGKWFCPN 403
            |. ..||.:|....|||:|||||:|||:|:||||.|||:.|||||||||||||..||||||:||.
Mouse   195 AK-QEREASPVEFAIDPNEPTYCLCNQVSYGEMIGCDNEQCPIEWFHFSCVSLTYKPKGKWYCPK 258

  Fly   404 CRGERPNVMKPKAQFLKELERYNKEKEEK 432
            |||:....|.      |..|:..||:..:
Mouse   259 CRGDNEKTMD------KSTEKTKKERRAR 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7379	NP_650656.1	ING	17..116	CDD:289749	35/98 (36%)
CG7379	NP_650656.1	PHD_ING1_2	360..404	CDD:277059	34/43 (79%)
Ing2	NP_075992.2	ING	28..122	CDD:289749	35/96 (36%)
		TNG2	31..260	CDD:227367	100/387 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..204		26/236 (11%)
		PHD_ING2	214..262	CDD:277153	37/47 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..281		6/25 (24%)
		PBR. /evidence=ECO:0000250\|UniProtKB:Q9H160	265..281		5/21 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832006
Domainoid	1	1.000	88	1.000	Domainoid score	I7918
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3569
Isobase	1	0.950	-	0	Normalized mean entropy	S2440
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1434088at2759
OrthoFinder	1	1.000	-	-		FOG0000296
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10333
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2364
SonicParanoid	1	1.000	-	-		X195
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.840