DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7379 and ing1

DIOPT Version :9

Sequence 1:	NP_650656.1	Gene:	CG7379 / 42140	FlyBaseID:	FBgn0038546	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_001035446.1	Gene:	ing1 / 678608	ZFINID:	ZDB-GENE-060421-4388	Length:	309	Species:	Danio rerio

Alignment Length:	429	Identity:	124/429 - (28%)
Similarity:	189/429 - (44%)	Gaps:	124/429 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MINPIASESEAINSATYVDNYIDSVENLPDDVQRQLSRIRDIDVQYRGLIRDVDHYYDLYLSLQN 65
            |:||.::...:.....||:.|::.||:||.|:||.:|.:::||.:|:.::.::|..|:.:   :.
Zfish     1 MLNPSSNGESSHVVVNYVEEYLELVESLPLDLQRCVSLMKEIDAKYQEILNELDEAYEKH---RQ 62

  Fly    66 SADAGRRSRSISRMHQSLIQAQELGDEKMQIVNHMQEIIDGKLRQLDTDQQNLDLKEDRDRYALL 130
            .:|..:|.|.:..:.:|||:.:||||||:||...|.|:::.:.|||:...:......|....::.
Zfish    63 ESDPVQRRRLLHCIQRSLIRTEELGDEKIQIAGQMVEMVENRSRQLEWHGELFQASHDSPESSVS 127

  Fly   131 DDGTPSKLQRLQSPMREQGNQAGTGNGGLNGNGLLSAKDLYALGGYAGGVVPGSNAMTSGNGGGS 195
            ...|||                     .:....:.:..|          ::..::.:|:......
Zfish   128 VGSTPS---------------------AITTTAMTTISD----------ILLSASKLTANRRREE 161

  Fly   196 TPNSERSSHVSNGGNSGSNGNASGGGGGELQRTGSKRSRRRNESVVNNGSSLEMGGNESNSANEA 260
            ||:|                         :.::|.|||||:     .|||  |...|.:.|....
Zfish   162 TPSS-------------------------VDKSGGKRSRRQ-----KNGS--ENRENSNYSLEHI 194

  Fly   261 SGSGGGSGERKSSLGGASGAGQGRKASLQSASGSLASGSAATSSGAAGGGGASGAGVVGGNNSGK 325
            .....|:.:.|..           |||             ||||                    |
Zfish   195 EDVSSGTPKEKKP-----------KAS-------------ATSS--------------------K 215

  Fly   326 KKKRKVRGSGASNANASTREETPPPETIDPDEPTYCVCNQISFGEMILCDNDLCPIEWFHFSCVS 390
            ||||        :.:...||.:|....|||:|||||:|.|:|:||||.||||.|.|||||||||.
Zfish   216 KKKR--------SKSKQDREPSPTDLPIDPNEPTYCLCEQVSYGEMIGCDNDECTIEWFHFSCVD 272

  Fly   391 LVLKPKGKWFCPNCRGERPNVMKPKAQFLKELERYNKEK 429
            |..||||||:||.|||:....|.      |.|||..||:
Zfish   273 LHHKPKGKWYCPKCRGDNEKTMD------KALERSKKER 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7379	NP_650656.1	ING	17..116	CDD:289749	35/98 (36%)
CG7379	NP_650656.1	PHD_ING1_2	360..404	CDD:277059	32/43 (74%)
ing1	NP_001035446.1	ING	17..111	CDD:289749	35/96 (36%)
		TNG2	18..287	CDD:227367	110/386 (28%)
		PHD_ING1_2	242..286	CDD:277059	32/43 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574877
Domainoid	1	1.000	87	1.000	Domainoid score	I7985
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H40119
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3647
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1434088at2759
OrthoFinder	1	1.000	-	-		FOG0000296
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_109185
Panther	1	1.100	-	-	LDO	PTHR10333
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2364
SonicParanoid	1	1.000	-	-		X195
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.830