DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7379 and ING3

DIOPT Version :9

Sequence 1:	NP_650656.1	Gene:	CG7379 / 42140	FlyBaseID:	FBgn0038546	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_061944.2	Gene:	ING3 / 54556	HGNCID:	14587	Length:	418	Species:	Homo sapiens

Alignment Length:	476	Identity:	115/476 - (24%)
Similarity:	189/476 - (39%)	Gaps:	146/476 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 YVDNYIDSVENLPDDVQRQLSRIRDIDVQYRGLIRDVDHYYDLYLSLQNSADAGRRSRSISRMHQ 81
            |:::|::.:|.||.|::.:.:.:|::|:|.:..:..::.....:...........|...::.:.:
Human     3 YLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVSEFFMNAKKNKPEWREEQMASIKK 67

  Fly    82 SLIQAQELGDEKMQIVNHMQEIIDGKLRQLDTDQQNLDLKEDRDRYAL--------LDDGTPS-- 136
            ...:|.|..|||:|:.|.:.:::|..||:||.:.....::.:.|...:        |:..|||
Human    68 DYYKALEDADEKVQLANQIYDLVDRHLRKLDQELAKFKMELEADNAGITEILERRSLELDTPSQP 132

  Fly   137 ----------------------------------KLQRLQSPMREQGNQAGTGNGGLNGNGLLSA 167
                                              |.:.|.|.:....::..| .|..|.|...|:
Human   133 VNNHHAHSHTPVEKRKYNPTSHHTTTDHIPEKKFKSEALLSTLTSDASKENT-LGCRNNNSTASS 196

  Fly   168 KDLY------ALGGYAGGVVPGSNAMTSGNGGGSTPNSERSSHVSNGGNSGSNGNASGGGGGELQ 226
            .:.|      .||.|..|      :::||.|.|:...:...:                     :|
Human   197 NNAYNVNSSQPLGSYNIG------SLSSGTGAGAITMAAAQA---------------------VQ 234

  Fly   227 RTGSKRSRRRN-------ESVVNNGSSLEMGGNESNSANEASGSGGGSG------ERKSSLGGAS 278
            .|...:..||.       |:..||...|   |.|.:.|.|..|....|.      :..||  .|:
Human   235 ATAQMKEGRRTSSLKASYEAFKNNDFQL---GKEFSMARETVGYSSSSALMTTLTQNASS--SAA 294

  Fly   279 GAGQGRKASLQSASGSLASGSAATSSGAAGGGGASGAGVVGGNNSGKKKKRKVRGSGASNANAST 343
            .:..|||:...:.|.|..|.|:::||                             |.:|.:::||
Human   295 DSRSGRKSKNNNKSSSQQSSSSSSSS-----------------------------SLSSCSSSST 330

  Fly   344 ------REETPPPE---------TIDPDEPTYCVCNQISFGEMILCDNDLCPIEWFHFSCVSLVL 393
                  ::.|..||         |.||:||.||:|||:|:|||:.|||..|||||||:.||.|..
Human   331 VVQEISQQTTVVPESDSNSQVDWTYDPNEPRYCICNQVSYGEMVGCDNQDCPIEWFHYGCVGLTE 395

  Fly   394 KPKGKWFCPNC------RGER 408
            .|||||:||.|      ||.|
Human   396 APKGKWYCPQCTAAMKRRGSR 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7379	NP_650656.1	ING	17..116	CDD:289749	22/98 (22%)
CG7379	NP_650656.1	PHD_ING1_2	360..404	CDD:277059	29/43 (67%)
ING3	NP_061944.2	ING	3..102	CDD:404028	22/98 (22%)
		TNG2	4..410	CDD:227367	111/467 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..165		3/37 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..325		13/69 (19%)
		PHD_ING3	362..406	CDD:277060	29/43 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1434088at2759
OrthoFinder	1	1.000	-	-		FOG0000296
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2364
SonicParanoid	1	1.000	-	-		X195
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850