DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7379 and ing3

DIOPT Version :9

Sequence 1:	NP_650656.1	Gene:	CG7379 / 42140	FlyBaseID:	FBgn0038546	Length:	433	Species:	Drosophila melanogaster
Sequence 2:	NP_957231.1	Gene:	ing3 / 393911	ZFINID:	ZDB-GENE-040109-3	Length:	416	Species:	Danio rerio

Alignment Length:	462	Identity:	112/462 - (24%)
Similarity:	186/462 - (40%)	Gaps:	120/462 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 YVDNYIDSVENLPDDVQRQLSRIRDIDVQYRGLIRDVDHYYDLYLSLQNSADAGRRSRSISRMHQ 81
            |:::|::.:|.||.|::.:.:.:|::|:|.:..:..::...:.:.:.........|...:..:.:
Zfish     3 YLEDYLEMIEQLPMDLRDRFTEMREMDLQVQNAMDQLEQRVNEFFTNAKKNKPEWREEQMEIIKK 67

  Fly    82 SLIQAQELGDEKMQIVNHMQEIIDGKLRQLD---------TDQQNLDLKEDRDRYALLDD----- 132
            ...:|.|..|||:|:.|.:.:::|..||:||         .:..|..:.|..:|.:|..|
Zfish    68 DYYKALEDADEKVQLANQIYDLVDRHLRKLDQELAKFKMELEADNAGITEILERRSLEMDSPSQP 132

  Fly   133 -----------------GTPS------------KLQRLQSPMREQGNQAGTGNGGLNGNGLLSAK 168
                             .||:            |.:.|.|.:.....:..|  .|...|...|
Zfish   133 VNNHHVHSHTTVEKRKYSTPAHHTTEHVPEKKFKSEALLSTLTSDATKENT--PGCRANSTSS-- 193

  Fly   169 DLYALGGYAGGVVPGSNAMTSGNGGGSTPNSERSSHVSNGGNSGSNGNASGGGGGELQRTGSKRS 233
                           ||:|.:.|...|..:|...|.:..|..:|: |..|......:|.|...:.
Zfish   194 ---------------SNSMYNVNSSQSLTSSYNLSPLPAGPAAGA-GAISMAAAQAVQATAQMKE 242

  Fly   234 RRRN-------ESVVNN---GSSLEMGGNESNSANEASGSGGGSGERKSSLGGASGAGQGRKASL 288
            .||.       |:|.||   |....|..:.|:.::.|..|   :..:..:...:|.:...||...
Zfish   243 GRRTSSLKASYEAVKNNDFLGRDFTMSRDSSSYSSSALAS---TLTQPLTSTNSSDSRTARKTKS 304

  Fly   289 QSASGSLASGSAATSSGAAGGGGASGAGVVGGNNSGKKKKRKVRGSGASNANASTRE--ETPPPE 351
            .:.|.:..|.|:::||..                           |..|:::|...|  :|...|
Zfish   305 NTKSSNHQSSSSSSSSSL---------------------------SSCSSSSALAHELVQTTVTE 342

  Fly   352 ---------TIDPDEPTYCVCNQISFGEMILCDNDLCPIEWFHFSCVSLVLKPKGKWFCPNC--- 404
                     |.||:||.||:|||:|:|||:.|||..|||||||:.||.|...|||||:||.|
Zfish   343 TDTSSQVDWTYDPNEPRYCICNQVSYGEMVGCDNQDCPIEWFHYGCVGLTEAPKGKWYCPQCTAA 407

  Fly   405 ---RGER 408
               ||.|
Zfish   408 MKRRGSR 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7379	NP_650656.1	ING	17..116	CDD:289749	22/107 (21%)
CG7379	NP_650656.1	PHD_ING1_2	360..404	CDD:277059	29/43 (67%)
ing3	NP_957231.1	ING	3..102	CDD:289749	22/98 (22%)
		TNG2	4..408	CDD:227367	108/453 (24%)
		PHD_ING3	360..404	CDD:277060	29/43 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1434088at2759
OrthoFinder	1	1.000	-	-		FOG0000296
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2364
SonicParanoid	1	1.000	-	-		X195
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.850