Protein Alignment CG43102 and ARHGEF17

DIOPT Version :10

• Sequence 1: NP_001247156.1
• Gene: CG43102 / 42137
• FlyBaseID: FBgn0262562
• Length: 2519
• Species: Drosophila melanogaster
• Sequence 2: NP_055601.2
• Gene: ARHGEF17 / 9828
• HGNCID: 21726
• Length: 2063
• Species: Homo sapiens
• Alignment Length: 2236
• Identity: 622/2236 - (27%)
• Similarity: 931/2236 - (41%)
• Gaps: 623/2236 - (27%)

  Fly   648 RRNTLDRFQRLGFGRKSSPAAAASASTSSSSPSSTSGPEKQRKTSDRSERLRELTEL--LRGGGG 710
            ||....|......|.:......|:|..::..|:..:.|              .:||:  |.||.|
Human    87 RRFDAPRLDDGSAGTRDGGVLPAAAEEAAEGPARGAWP--------------SVTEMRKLFGGPG 137

  Fly   711 GGSSSRASSTPTPPPP------PP------PPVPPPR-----------KP--------RISHLER 744
            ....|..|.:|..|.|      ||      ||.||||           :|        |:...::
Human   138 SRRPSADSESPGTPSPDGAAWEPPARESRQPPTPPPRTCFPLAGLRSARPLTGPETEGRLRRPQQ 202

  Fly   745 Q-----------------------------------------DTGASQTSESEAGSAHLRMPSEE 768
            |                                         ...||.:.|.|.|...|  |..:
Human   203 QQERAQRPADGLHSWHIFSQPQAGARASCSSSSIAASYPVSRSRAASSSEEEEEGPPQL--PGAQ 265

  Fly   769 TTTRHSG----------GAGG--GGGGVGLSTAARIF-ASLRPNT---SLSNLEAFMLSN----- 812
            :...|.|          |.||  .||..||...:.:. ...||::   :||::.:..:|.
Human   266 SPAYHGGHSSGSDDDRDGEGGHRWGGRPGLRPGSSLLDQDCRPDSDGLNLSSMNSAGVSGSPEPP 330

  Fly   813 ------REK------SKSPP--PPAQQNHRP------AASRCVDAS--------ATASSSASFES 849
                  ||:      |.|||  |..|:..||      .|.|....|        |.:..|:.:.|
Human   331 TSPRAPREEGLREWGSGSPPCVPGPQEGLRPMSDSVGGAFRVAKVSFPSYLASPAGSRGSSRYSS 395

  Fly   850 TALASRPD---SRSAHKAAPFRSVSF--------SQIDCKSTLSALRDRLKRDKAIEAPSPSPTH 903
            |......|   ||.:.....:||.||        ||...::.......|..||...|     |..
Human   396 TETLKDDDLWSSRGSGGWGVYRSPSFGAGEGLLRSQARTRAKGPGGTSRALRDGGFE-----PEK 455

  Fly   904 SRE-EEIAPPDPGWVRIPL---KKTELSINLNYGQEKSLDHDAIQEEDIFSNELAASDSSGIVFP 964
            ||: :.::.||.....:.|   .:::||       |..:........|..||.|...||.....|
Human   456 SRQRKSLSNPDIASETLTLLSFLRSDLS-------ELRVRKPGGSSGDRGSNPLDGRDSPSAGGP 513

  Fly   965 VATASSV-IAAHA------TMESLTDTIQSETDCLIKEDVPPPVQPVVEITPPASSVSGSAPNLA 1022
            |.....: |.|.|      |::.||.|::........|      :|:....|..|::..|:..|.
Human   514 VGQLEPIPIPAPASPGTRPTLKDLTATLRRAKSFTCSE------KPMARRLPRTSALKSSSSELL 572

  Fly  1023 T----LMEEQLPLEAPPDNFLQTATTCEIPVPVYECAAQEWLETPAQEWVEVAPEEFGIVPETIQ 1083
            .    ..|:.||| ...|.::|.|.  ::...:....||       |:....||
Human   573 LTGPGAEEDPLPL-IVQDQYVQEAR--QVFEKIQRMGAQ-------QDDGSDAP----------- 616

  Fly  1084 PPIPHAACKISQTPSTLTTAVRSDLVPTISVSRSSEE--------GDELAKIEDEPQVEVATTAR 1140
            |..|..|..:::.                  .||.||        .||....:.||.|.......
Human   617 PGSPDWAGDVTRG------------------QRSQEELSGPESSLTDEGIGADPEPPVAAFCGLG 663

  Fly  1141 NTSMDRHIREYSQDDLDLANVDLRSSLEAIATPRHSTDERQRRHLDKSTKRKGMYIDNADWQAP- 1204
            .|.|.|.:                           |:...|..|                 ..|
Human   664 TTGMWRPL---------------------------SSSSAQTNH-----------------HGPG 684

  Fly  1205 TEAPQRGLALDISVANLNAIKPESPEANTPGASQMYISSPQSSYSFELNTPELEKGSPSWGSGGL 1269
            ||....|.||         :.||:|.  ||||.:.....|.|                  ||||
Human   685 TEDSLGGWAL---------VSPETPP--TPGALRRRRKVPPS------------------GSGG- 719

  Fly  1270 VRDKAQLLSNFSCHSSEEKDDASCRSLSYLRTDSTSDNECDRAIRERERERITSSPTP------- 1327
                ::|       |:.|..:| .||||             ..|.:|.|...:..||.
Human   720 ----SEL-------SNGEAGEA-YRSLS-------------DPIPQRHRAATSEEPTGFSVDSNL 759

  Fly  1328 --------------------SSGDYDYKRFSKRPLRGPYGQMLEAEMKKPNRMHFEEILEELRET 1372
                                :||..|:...|:.. :| |.:::::.::.|..:.        |..
Human   760 LGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEES-KG-YQEVIQSIVQGPGTLG--------RVV 814

  Fly  1373 DSLHLRGSAP-----------GVAAG-GTVGPSRNLPQYSNSMRVRKTSTFLPVPSHARAASTPS 1425
            |. .:.|.||           |..|| |..||        ....:|:....|| ||.:.......
Human   815 DD-RIAGKAPKKKSLSDPSRRGELAGPGFEGP--------GGEPIREVEPMLP-PSSSEPILVEQ 869

  Fly  1426 QLEHASKGISAATAQISVSAKNLSQA-----------ELDDQV------HHMKRAASEAPAPKSN 1473
            :.|....|.:.:.||   |.:.|.:|           .||.::      ..::|.:.:.|| :|:
Human   870 RAEPEEPGATRSRAQ---SERALPEALPPPATAHRNFHLDPKLADILSPRLIRRGSKKRPA-RSS 930

  Fly  1474 HSK---------RSQSMSTERPSQHHHHHGH---------------------GHGHSHGHHHAGK 1508
            |.:         ::.|:|..|||..|..|..                     ......|......
Human   931 HQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVPEPPTSVGPPVAVPEPIGFPTRAH 995

  Fly  1509 RSLDAGSGDKAAKN--------------------APLAGGTSGSGS-GGGGKAGLKPTPALLAEL 1552
            .:|.|.|.:...|.                    .|||...|.... ....:...:||||
Human   996 PTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLAAPPSAEAKPPEAARPADEPTPA----- 1055

  Fly  1553 LKGSSENMISEQRKKTIADTRTYVVQEIYRNEQSYVESLQTVVVKYLKVLKAPEHAGMIDTRTVD 1617
                     |:...|...|.|.:|...:...||||||||:|::..|::.||.||::.:.|...||
Human  1056 ---------SKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVD 1111

  Fly  1618 EIFFMVPDILEIHEKFLSDLKSRLDDWDVQQKVGDAFMDTFSKLEVLEVYTSFVNNCNRAKNAIR 1682
            |||..:|::||.||:||..::..:..|..|||||...:.:|||..::.:|:::::|...||:|:|
Human  1112 EIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVR 1176

  Fly  1683 SMKHQRPSFSKFLETTAREHKGKLTLDNLLIKPVQKFPNYELLFQRLIKHTDHDHPDTKHLQDVL 1747
            ..|..||:|.||||.:.||:|.|..|.:|:|||||:.|.||||.:.|:|||..||||...|.:..
Human  1177 VAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQ 1241

  Fly  1748 KLVHDILVHINCKEREIMENGQREATLRELEGVIEGITDLIAPERQFLLFDLVSMPSGQGARKDR 1812
            :.:..:...||...|...|..:....|:|:|..|||:.||.||.|:||..::|......|.:|||
Human  1242 RNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDR 1306

  Fly  1813 GFFLFNDLLVLTSIKKRSGTIRKPNSSICPGTVATTLDT-NKYKFLTKISLDCLEIVK-----SK 1871
            ..|||.||:|.|::|::||::|:.:.|:.  |.|:.:|| :|||.|.|:.|:..:|:|     :.
Human  1307 SLFLFTDLIVCTTLKRKSGSLRRSSMSLY--TAASVIDTASKYKMLWKLPLEDADIIKGASQATN 1369

  Fly  1872 DENIKRIVSEIETLAEDCNKLQQITDITVTIKYPHQYLEDVIRELHREVQRQLSERQTNDTQLNM 1936
            .|||::.:|.::   ||...|.|::.::.::.:|||.|:|.:|:|...:.|.|||:|.....|:.
Human  1370 RENIQKAISRLD---EDLTTLGQMSKLSESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSF 1431

  Fly  1937 ----LELTVSSPNGNQKLAVVFSKTEKRTQWEESFNEAKQKLAAT---LERHPIPEFLTSIPIRK 1994
                |||..:.|.|.......|...:.|..:|::|:|||:|||::   |:    ||||.:|||.|
Human  1432 PPTKLELCATRPEGTDSYIFEFPHPDARLGFEQAFDEAKRKLASSKSCLD----PEFLKAIPIMK 1492

  Fly  1995 TRAGLQFTCAAATLSD----NRDVWVCNSDGYVGQVCIMSLHPEPNVTSCNGVCNARILCVASVP 2055
            ||:|:||:|||.||:.    :.:||||||||||||||::||..||:|.:|..||:|||||:.:||
Human  1493 TRSGMQFSCAAPTLNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVP 1557

  Fly  2056 A-----------------------------YSSAASSRNSSSEQP----------AGSG------ 2075
            .                             ..:||....::..:|          ||||
Human  1558 GLQPRCHREPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMTPG 1622

  Fly  2076 -GQ-----------EEKDKRHTPQ-SYTQQLRDYRKSISPSFQSASASATATPEKKKLTPTPTPV 2127
             |:           .:.|...:|. |.|.|.:..|.:||.||.:..     ||..|:.|
Human  1623 LGEGDPRPELVPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEE-----TPSSKEAT------ 1676

  Fly  2128 AGGEPADAATTGGSDTQLELNLSSSDDETEAA----AASLNVAGSTGSTLVERVPSPAP------ 2182
                   |.||            ||::|.|..    :.|....|..|:       ||..
Human  1677 -------AETT------------SSEEEQEPGFLPLSGSFGPGGPCGT-------SPMDGRALRR 1715

  Fly  2183 SYHGH------QDSNPEEGESNQSTMWIGTEDGCIHVYNSTDNIRIKKNRIKIEHHSAVYSILYL 2241
            |.||.      :|....:.|:.||::|:||||||:|||.|:|:||.::|.:|::|.::|..||||
Human  1716 SSHGSFTRGSLEDLLSVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYL 1780

  Fly  2242 DNRVFVSLANGDICVYLRDGATSWNTCSSHCLSIGTVTSPVNKLLNVNGRLWCSIQGIIKVLDVE 2306
            :|:||||||||::.||.|:....|:..:...:::||..||:.|:::|.|||||..|..:.||..:
Human  1781 NNQVFVSLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPD 1845

  Fly  2307 TLTVVNQIQISSD-SKPITNMTVSNNHVWISIQNSAHIKCFHSNTHQLVTEVNLAPAVNKMLSNC 2370
            ||.:.:...:..| |:.:..|..|:..||::::.|||:..:|.:|.:.:.||::.|.|::||:..
Human  1846 TLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGS 1910

  Fly  2371 DEIIRQHKAACLRVTSLLCCKDLIWIGTSAGVLLTIPAQGYEKGAIN-----IVPTGIPHGHTGH 2430
            |.|||||||||||:|:||.|::|:|:||||||:||:|.   ..|.::     :.|||:..|||||
Human  1911 DAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPT---SPGTVSCPRAPLSPTGLGQGHTGH 1972

  Fly  2431 VRFLTFVE-TTGLEGAASGAGGGRDAGSSNSDEYTKQGSIKHSKSKSETNNTLIISGGDGYEDFR 2494
            ||||..|: ..|............|.|.........:.|..|..........|:|||||||||||
Human  1973 VRFLAAVQLPDGFNLLCPTPPPPPDTGPEKLPSLEHRDSPWHRGPAPARPKMLVISGGDGYEDFR 2037

  Fly  2495 -NSGANSLSEIAGREDSTNHLLIWQI 2519
             :||..|.||..||:|||||||:|::
Human  2038 LSSGGGSSSETVGRDDSTNHLLLWRV 2063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43102	NP_001247156.1	RhoGEF	1573..1758	CDD:238091	77/184 (42%)
		WD40_2	<2201..>2462	CDD:465964	112/267 (42%)
ARHGEF17	NP_055601.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..365		61/293 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	380..466		20/90 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	485..581		21/101 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	602..958		98/514 (19%)
		PHA03247	<829..1054	CDD:223021	42/237 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1034..1060		6/39 (15%)
		RhoGEF	1067..1252	CDD:238091	77/184 (42%)
		PH_19	1281..1402	CDD:465965	44/125 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1564..1584		0/19 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1616..1719		29/139 (21%)
		WD40_2	1724..>1978	CDD:465964	112/256 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1991..2020		4/28 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2036..2055		10/18 (56%)