DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43102 and ARHGEF10

DIOPT Version :9

Sequence 1:	NP_001247156.1	Gene:	CG43102 / 42137	FlyBaseID:	FBgn0262562	Length:	2519	Species:	Drosophila melanogaster
Sequence 2:	XP_024303103.1	Gene:	ARHGEF10 / 9639	HGNCID:	14103	Length:	1373	Species:	Homo sapiens

Alignment Length:	1844	Identity:	358/1844 - (19%)
Similarity:	624/1844 - (33%)	Gaps:	688/1844 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   888 LKRDKAIEAPSP-SPTHSREE-----------EIAPPDPGWVRIPLKKTELSINLNYGQE---KS 937
            :::.:.:...|| :|:.:|.|           |..||.|.       :.|:..:.|..:|   :.
Human     1 MRQSQLLLVGSPRAPSLNRAERGIWSCSMDQREPLPPAPA-------ENEMKYDTNNNEEEEGEQ 58

  Fly   938 LDHDAIQEEDIFSNELAASDSSGIVFPVATASSVIAAHATMESLTDTIQSETDCL---IKEDVPP 999
            .|.|:       .:|:..:|......|....:....|.|.... .|...:||..:   .|..:|.
Human    59 FDFDS-------GDEIPEADRQAPSAPETGGAGASEAPAPTGG-EDGAGAETTPVAEPTKLVLPM 115

  Fly  1000 PVQP--VVEITPPASSVSGSAPNLATLMEEQLPLEAPPDNFLQTATTCEIPVPVYECAAQEWLET 1062
            .|.|  |::|||              ..|:|     ||           .|||    :|:|
Human   116 KVNPYSVIDITP--------------FQEDQ-----PP-----------TPVP----SAEE---- 142

  Fly  1063 PAQEWVEVAPEEFGI-VPETIQPPIPHAACKISQTPSTLTTAVRSDLVPTISVSRSSEEGDELAK 1126
                      |..|: ||.....|:|   |..: .||.|...:.:...|.|..:.|.:|..|..:
Human   143 ----------ENVGLHVPCGYLVPVP---CGYA-VPSNLPLLLPAYSSPVIICATSLDEEAETPE 193

  Fly  1127 I-EDEPQVEVATTARNTSMDRHIREYSQDDLDLANVDLRSSLEAIATPRHSTDERQRRHLDKSTK 1190
            : ||.....:::....||.|:..||.|                  |..|.:.|..
Human   194 VTEDRQPNSLSSEEPPTSEDQVGREDS------------------ALARWAADPA---------- 230

  Fly  1191 RKGMYIDNADWQAPTEAPQRGLALDISVANLNAIKPESPEANTPGASQMYISSPQSSYSFELNTP 1255
                   |..|.   |.|:            .||..:.|..|:.       |.|.     |:...
Human   231 -------NTAWM---ENPE------------EAIYDDVPRENSD-------SEPD-----EMIYD 261

  Fly  1256 ELEKGSPSWGSGGLVRDKAQLLSNFSCHSSEEKDDASCRSLSYLRTDSTSDNECDRAI-----RE 1315
            ::|.|.    .||              :||.|...:|....||   :..||:||...|     |.
Human   262 DVENGD----EGG--------------NSSLEYGWSSSEFESY---EEQSDSECKNGIPRSFLRS 305

  Fly  1316 RERERITSSPTPSSGDYDYKRFSKRPLRGPYGQMLEAEMKKPNRMHFEEILEELRETDSLHLRGS 1380
            ..:::::...|.....|:.|   .|.|......::|              :::||:...|.::..
Human   306 NHKKQLSHDLTRLKEHYEKK---MRDLMASTVGVVE--------------IQQLRQKHELKMQKL 353

  Fly  1381 APGVAAGGTVGPSRNLPQYSNSMRVRKTSTFLPVPSHARAASTPSQLEHASKGISAATAQISVSA 1445
            ......|...|..|      ....|::..:|:      |..|..:| :|.|
Human   354 VKAAKDGTKDGLER------TRAAVKRGRSFI------RTKSLIAQ-DHRS-------------- 391

  Fly  1446 KNLSQAELDDQVHHMKRAASEAPAPKSNHSKRSQSMSTERPSQHHHHHGHGHGHSHGHHHAGKRS 1510
                  .|:::                      |::..:...:|
Human   392 ------SLEEE----------------------QNLFIDVDCKH--------------------- 407

  Fly  1511 LDAGSGDKAAKNAPLAGGTSGSGSGGGGKAGLKPTPALLAELLKGSSENMISEQRKKTIADTRTY 1575
                                              ..|:|..:.:|.|:..:          .|.|
Human   408 ----------------------------------PEAILTPMPEGLSQQQV----------VRRY 428

  Fly  1576 VVQEIYRNEQSYVESLQTVVVKYLKVLKAPEHAGMIDTRTVDEIFFMVPDILEIHEKFLSDLKSR 1640
            ::..:..:|::||::|:.::.:|.|.|...| ..::..|.:..:|:.|.:||:.|..|...|.||
Human   429 ILGSVVDSEKNYVDALKRILEQYEKPLSEME-PKVLSERKLKTVFYRVKEILQCHSLFQIALASR 492

  Fly  1641 LDDWDVQQKVGDAFMDTFSKLEVLEVYTSFVNNCNRAKNAIRSMKHQRPSFSKFLETTAREHKGK 1705
            :.:||..:.:||.|:.:|||..||:.|:.:|||.:.|...::.....:|:|.:||:........:
Human   493 VSEWDSVEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKQEQEASPDR 557

  Fly  1706 LTLDNLLIKPVQKFPNYELLFQRLIKHTDHDHPDTKHLQDVLKLVHDILVHINCKEREIMENGQR 1770
            .||.:|::||:|:||.:.||.|.::|:|...|||...||..|..:..:...:|  ||      :|
Human   558 TTLYSLMMKPIQRFPQFILLLQDMLKNTSKGHPDRLPLQMALTELETLAEKLN--ER------KR 614

  Fly  1771 EATLR-ELEGVIEGITD-----LIAPERQFL-----LFDLVSMPSGQGAR-KDRGFFLFNDLLVL 1823
            :|..| |::.:.:.|.:     |::...::|     :.:.|....|:..: |:|..|:.||:|:.
Human   615 DADQRCEVKQIAKAINERYLNKLLSSGSRYLIRSDDMIETVYNDRGEIVKTKERRVFMLNDVLMC 679

  Fly  1824 TSIKKRSGTIRKPNSSICPGTVATTLDTNKYKFLTKISL---DCLE------------------- 1866
            .::..|            |...:..:.:.:|.....:.|   |.:|
Human   680 ATVSSR------------PSHDSRVMSSQRYLLKWSVPLGHVDAIEYGSSAGTGEHSRHLAVHPP 732

  Fly  1867 -----IVKSKDENI----KRIVSEIETLAEDCNKLQQITDITVTIKYPHQYL------------- 1909
                 :..:|...:    .::..:::.|..|.|.:.|||.:...:|..:|.|
Human   733 ESLAVVANAKPNKVYMGPGQLYQDLQNLLHDLNVIGQITQLIGNLKGNYQNLNQSVAHDWTSGLQ 797

  Fly  1910 ------EDVIRELH-REVQRQLSERQ-------------------TNDTQLNMLELTVSSPNGNQ 1948
                  ||.||... ..:|.||..:|                   ..::.:|.|::.
Human   798 RLILKKEDEIRAADCCRIQLQLPGKQDKSGRPTFFTAVFNTFTPAIKESWVNSLQMA-------- 854

  Fly  1949 KLAVVFSKTEKRTQW---EESFNEAKQKLAATLERHPIPEFLTSIPIRKTR-AGLQFTCAAAT-- 2007
            |||:   :.|....|   |:..|..|:      |:||:  .:..:|:...: ...:..|||..
Human   855 KLAL---EEENHMGWFCVEDDGNHIKK------EKHPL--LVGHMPVMVAKQQEFKIECAAYNPE 908

  Fly  2008 --LSDNRD----------VWVCNSDGYVGQVCIMSL-HPEPNVTSCNGVCNARILCVASVPAYSS 2059
              |::...          :|:.:....:||:.|:|. :..|.|..|..| .:||||:..||.
Human   909 PYLNNESQPDSFSTAHGFLWIGSCTHQMGQIAIVSFQNSTPKVIECFNV-ESRILCMLYVPV--- 969

  Fly  2060 AASSRNSSSEQPAGSGGQEEKDKRHTPQSYTQQLRDYRKSISPSFQSASASATATPEKKKLTPTP 2124
                                ::||..|
Human   970 --------------------EEKRREP-------------------------------------- 976

  Fly  2125 TPVAGGEPADAATTGGSDTQLELNLSSSDDETEAAAASLNVAGSTGSTLVERVPSPAPSYHGHQD 2189
                |..|                    |.||.|..||             .||
Human   977 ----GAPP--------------------DPETPAVRAS-------------DVP----------- 993

  Fly  2190 SNPEEGESNQSTMWIGTEDGCIHVYNSTDNIRIKKNRIKIEH-----HSAVYSILYLDNRVFVSL 2249
                       |:.:|||:|.|.:|.|:..    ..:::::|     .|.|.|:......::..|
Human   994 -----------TICVGTEEGSISIYKSSQG----SKKVRLQHFFTPEKSTVMSLACTSQSLYAGL 1043

  Fly  2250 ANGDICVYLRDGATSWNTCSSHCLSIGTVTSPVNKLLNVNGRLWCSIQGIIKVLDVETLTVVNQI 2314
            .||.:..|.|....||::.....:.:|.:  ||..||.:...||.:..|.:.::.|||..|..|:
Human  1044 VNGAVASYARAPDGSWDSEPQKVIKLGVL--PVRSLLMMEDTLWAASGGQVFIISVETHAVEGQL 1106

  Fly  2315 QI-SSDSKPITNMTVSNNHVWISIQNSAHIKCFHSNTHQLVTEVNLAPAVNKMLSNCDEIIRQHK 2378
            :. ..:...|::|.||...:||:..:.:.::.||:.|.:.:.::|:|..|:.||..       |:
Human  1107 EAHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLPG-------HQ 1164

  Fly  2379 AACLRVTSLLCCKDLIWIGTSAGVLLTIPA---QGYEK----GAINIVPTGIPHGHTGHVRFLTF 2436
            .  |.|||||.|..|:.:|||.|||:.:|.   ||..|    |.::.      |.|...|:|:
Human  1165 R--LSVTSLLVCHGLLMVGTSLGVLVALPVPRLQGIPKVTGRGMVSY------HAHNSPVKFI-- 1219

  Fly  2437 VETTGL------------------------EGAASGAGG--------------GRDAGS--SNSD 2461
            |..|.|                        :...||..|              |...||  ..||
Human  1220 VLATALHEKDKDKSRDSLAPGPEPQDEDQKDALPSGGAGSSLSQGDPDAAIWLGDSLGSMTQKSD 1284

  Fly  2462 EYTKQG--SIKHSKS-----------------------------KSETNNTLIISGGDGYEDFRN 2495
            ..:..|  |:.|..|                             |::.::.|::.||.|:.....
Human  1285 LSSSSGSLSLSHGSSSLEHRSEDSTIYDLLKDPVSLRSKARRAKKAKASSALVVCGGQGHRRVHR 1349

  Fly  2496 SGANSLSEIAGREDSTNHLLIWQI 2519
            ....     ..:|:....:::|||
Human  1350 KARQ-----PHQEELAPTVMVWQI 1368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43102	NP_001247156.1	RhoGEF	1576..1758	CDD:279015	56/181 (31%)
CG43102	NP_001247156.1	PH-like	1750..>1889	CDD:302622	26/181 (14%)
ARHGEF10	XP_024303103.1	PTZ00441	<27..278	CDD:240420	78/397 (20%)
		RhoGEF	426..610	CDD:238091	58/184 (32%)
		PH-like	643..>707	CDD:327399	12/75 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3522
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D43489at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5001
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850