Protein Alignment CG43102 and Arhgef10l

DIOPT Version :10

• Sequence 1: NP_001247156.1
• Gene: CG43102 / 42137
• FlyBaseID: FBgn0262562
• Length: 2519
• Species: Drosophila melanogaster
• Sequence 2: NP_001277732.1
• Gene: Arhgef10l / 72754
• MGIID: 1920004
• Length: 1280
• Species: Mus musculus
• Alignment Length: 1149
• Identity: 261/1149 - (22%)
• Similarity: 437/1149 - (38%)
• Gaps: 329/1149 - (28%)

  Fly  1538 GKAGLKPTPALLAELLKGSSENMISEQRKKTIADTRTYVVQEIYRNEQSYVESLQTVVVKYLKVL 1602
            |...:||....|..:..|.|...:          .|.:::..|.::|.||||||:.::..|...|
Mouse   290 GVTDIKPPAPELGPMPDGLSPQQV----------VRRHILGSIVQSEGSYVESLKRILQDYRNPL 344

  Fly  1603 KAPEHAGMIDTRTVDEIFFMVPDILEIHEKFLSDLKSRLDDWDVQQKVGDAFMDTFSKLEVLEVY 1667
            ...|... :..|....:||.|.:||..|..|...|.||:.:||..:|:||.|:.:|||..||:||
Mouse   345 MEMEPKA-LSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVY 408

  Fly  1668 TSFVNNCNRAKNAIRSMKHQRPSFSKFLETTAREHKGKLTLDNLLIKPVQKFPNYELLFQRLIKH 1732
            :.:|||...|.:.|:.....:|:|.:||:........::||..|::||||:||.:.||.|.::|:
Mouse   409 SDYVNNFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQDMLKN 473

  Fly  1733 TDHDHPDTKHLQDVLKLVHDILVHINCKEREIMENGQREATLRELEGVIEGITD-------LIAP 1790
            |...|||...||..|..:..:...:| :::.:.:.      :.|::.:.:.::|       |.:.
Mouse   474 TPRGHPDRLSLQLALTELETLAEKLN-EQKRLADQ------VAEIQQLTKSVSDRSSLNKLLTSG 531

  Fly  1791 ERQFLLFDLVSM----PSGQGAR-KDRGFFLFNDLLVLTSIKKRSGTIRKPN--------SSICP 1842
            :||.||.:.::.    ..||..: |:|..||.||:||..:|.      .||:        ||:.|
Mouse   532 QRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANIN------FKPSNHRGQLEISSLVP 590

  Fly  1843 -GTVATTLDTNKYKFLTKISLDCLEIVK--------SKDENI----------------------- 1875
             |.        ||......:|..:::|:        .||..:
Mouse   591 LGP--------KYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGP 647

  Fly  1876 KRIVSEIETLAEDCNKLQQITDITVTIKYPHQYLE-DVIRELHREVQRQLSERQTNDTQLNMLEL 1939
            .|:..|::.|.:|...::|||.:..|:...:|.|. .|.::....:||.:..::......|...|
Mouse   648 PRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRL 712

  Fly  1940 TVSSPNGNQKLAVVFSKTEKRTQWEESFNEAKQKLAATLERHPIP---EFLTSIPIRK------- 1994
            .:..|          .|.:|                   ...||.   .|:|..|:.|
Mouse   713 RLLLP----------GKPDK-------------------SGRPISFMVVFITPNPLSKISWVNRL 748

  Fly  1995 --TRAGLQFTCAAATLSDNRDVWVCNSDGYVGQVCIMSLHPEPNVTSCNGVCNARILC---VASV 2054
              .:.||:        .:|:..|:|               |:.:..|     .|...|   ...|
Mouse   749 HLAKIGLR--------EENQPGWLC---------------PDEDKKS-----KAPFWCPILACCV 785

  Fly  2055 PAYSSAASSRNSSSEQPAGSGGQEEKDKRHTPQSYTQQLRDYRKSISPSFQSASASATATPEKKK 2119
            ||:||...|..        .||..     |:|             ::......||.:|:.|:...
Mouse   786 PAFSSRTLSLQ--------LGGLV-----HSP-------------VNSPLLGFSAVSTSLPQGYL 824

  Fly  2120 LTPTPTPVAGGEPADAATTGGSDTQLEL-NLSSSDDETEAAAASLNVAGSTGSTLVERVPSPAPS 2183
            .      |.||:.       |:..|:|: :|:.....|   ..|..||...  ..:|.:|.|...
Mouse   825 W------VGGGQE-------GAGGQVEIFSLNRPSPRT---VKSFPVAAPV--LCIEYIPDPEEE 871

  Fly  2184 YHGHQDSN--PEEGESNQSTMWIGTEDGCIHVYNSTDN----IRIKKN----RIKIEHHSAVYSI 2238
            ..|.::|.  .:...:...|:.:|.:||.|.:|.|.|.    :...|:    .:....||..|
Mouse   872 AEGAEESRAATDPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFY-- 934

  Fly  2239 LYLDNRVFVSLANGDICVYLR-DGATSWNTCS-SHCLSIGTVTSPVNKLLNVNGRLWCSIQGIIK 2301
                  :...|.:|.:..|.| .|...|:..| ..|:::|  ..|:..||::....|.|....:.
Mouse   935 ------LLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVG--PGPIRTLLSLEDAAWASCGPRVT 991

  Fly  2302 VLDVETLTVVNQIQISSD-SKPITNMTVSNNHVWISIQNSAHIKCFHSNTHQLVTEVNLAPAVNK 2365
            |||..||......:...| :..:|:|..:.:.||::..:.:.|:.||:.|.:.:.|:|:|.....
Mouse   992 VLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTF 1056

  Fly  2366 MLSNCDEIIRQHKAACLRVTSLLCCKDLIWIGTSAGVLLTIPAQGYE-------KGAINIVPTGI 2423
            :|..     ::|    |.|||||.|:.|:|:||..||::.:|....|       ||.:::
Mouse  1057 LLPG-----QKH----LCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSL----- 1107

  Fly  2424 PHGHTGHVRFLTF---------------------VETTGLEGAASGAGGGRDAGSSNSDEYTKQ- 2466
             :||.|.|.||..                     .|....:|.|.....|.|  |..:.|.|::
Mouse  1108 -NGHCGPVAFLAVAMSILAPDILRSDQEEAEGPQAEEDKPDGQAHETVPGPD--SHTARELTRKK 1169

  Fly  2467 -----------------------------GSIKHSKS-------------------------KSE 2477
                                         .:::||:.                         :.|
Mouse  1170 GILLQYRLRSTAHLPGPLLSVREPAPADGSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKE 1234

  Fly  2478 TNNTLIISGGDGYEDFRNS--GANSLSEIAGREDSTNHLLIWQI 2519
            ..:..|||||.||..|..:  |.:..:......|||  |||||:
Mouse  1235 ICSVAIISGGQGYRHFGGAPGGLSGRAAPCSETDST--LLIWQV 1276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43102	NP_001247156.1	RhoGEF	1573..1758	CDD:238091	65/184 (35%)
		WD40_2	<2201..>2462	CDD:465964	74/299 (25%)
Arhgef10l	NP_001277732.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..94
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..202
		RhoGEF	315..499	CDD:238091	65/184 (35%)
		PH_19	524..679	CDD:465965	36/168 (21%)
		WD40_2	787..1278	CDD:465964	124/563 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1133..1163		6/31 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1186..1207		2/20 (10%)