DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43102 and Arhgef10l

DIOPT Version :9

Sequence 1:	NP_001247156.1	Gene:	CG43102 / 42137	FlyBaseID:	FBgn0262562	Length:	2519	Species:	Drosophila melanogaster
Sequence 2:	NP_001277732.1	Gene:	Arhgef10l / 72754	MGIID:	1920004	Length:	1280	Species:	Mus musculus

Alignment Length:	1149	Identity:	261/1149 - (22%)
Similarity:	437/1149 - (38%)	Gaps:	329/1149 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1538 GKAGLKPTPALLAELLKGSSENMISEQRKKTIADTRTYVVQEIYRNEQSYVESLQTVVVKYLKVL 1602
            |...:||....|..:..|.|...:          .|.:::..|.::|.||||||:.::..|...|
Mouse   290 GVTDIKPPAPELGPMPDGLSPQQV----------VRRHILGSIVQSEGSYVESLKRILQDYRNPL 344

  Fly  1603 KAPEHAGMIDTRTVDEIFFMVPDILEIHEKFLSDLKSRLDDWDVQQKVGDAFMDTFSKLEVLEVY 1667
            ...|... :..|....:||.|.:||..|..|...|.||:.:||..:|:||.|:.:|||..||:||
Mouse   345 MEMEPKA-LSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVY 408

  Fly  1668 TSFVNNCNRAKNAIRSMKHQRPSFSKFLETTAREHKGKLTLDNLLIKPVQKFPNYELLFQRLIKH 1732
            :.:|||...|.:.|:.....:|:|.:||:........::||..|::||||:||.:.||.|.::|:
Mouse   409 SDYVNNFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQDMLKN 473

  Fly  1733 TDHDHPDTKHLQDVLKLVHDILVHINCKEREIMENGQREATLRELEGVIEGITD-------LIAP 1790
            |...|||...||..|..:..:...:| :::.:.:.      :.|::.:.:.::|       |.:.
Mouse   474 TPRGHPDRLSLQLALTELETLAEKLN-EQKRLADQ------VAEIQQLTKSVSDRSSLNKLLTSG 531

  Fly  1791 ERQFLLFDLVSM----PSGQGAR-KDRGFFLFNDLLVLTSIKKRSGTIRKPN--------SSICP 1842
            :||.||.:.::.    ..||..: |:|..||.||:||..:|.      .||:        ||:.|
Mouse   532 QRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANIN------FKPSNHRGQLEISSLVP 590

  Fly  1843 -GTVATTLDTNKYKFLTKISLDCLEIVK--------SKDENI----------------------- 1875
             |.        ||......:|..:::|:        .||..:
Mouse   591 LGP--------KYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGP 647

  Fly  1876 KRIVSEIETLAEDCNKLQQITDITVTIKYPHQYLE-DVIRELHREVQRQLSERQTNDTQLNMLEL 1939
            .|:..|::.|.:|...::|||.:..|:...:|.|. .|.::....:||.:..::......|...|
Mouse   648 PRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRL 712

  Fly  1940 TVSSPNGNQKLAVVFSKTEKRTQWEESFNEAKQKLAATLERHPIP---EFLTSIPIRK------- 1994
            .:..|          .|.:|                   ...||.   .|:|..|:.|
Mouse   713 RLLLP----------GKPDK-------------------SGRPISFMVVFITPNPLSKISWVNRL 748

  Fly  1995 --TRAGLQFTCAAATLSDNRDVWVCNSDGYVGQVCIMSLHPEPNVTSCNGVCNARILC---VASV 2054
              .:.||:        .:|:..|:|               |:.:..|     .|...|   ...|
Mouse   749 HLAKIGLR--------EENQPGWLC---------------PDEDKKS-----KAPFWCPILACCV 785

  Fly  2055 PAYSSAASSRNSSSEQPAGSGGQEEKDKRHTPQSYTQQLRDYRKSISPSFQSASASATATPEKKK 2119
            ||:||...|..        .||..     |:|             ::......||.:|:.|:...
Mouse   786 PAFSSRTLSLQ--------LGGLV-----HSP-------------VNSPLLGFSAVSTSLPQGYL 824

  Fly  2120 LTPTPTPVAGGEPADAATTGGSDTQLEL-NLSSSDDETEAAAASLNVAGSTGSTLVERVPSPAPS 2183
            .      |.||:.       |:..|:|: :|:.....|   ..|..||...  ..:|.:|.|...
Mouse   825 W------VGGGQE-------GAGGQVEIFSLNRPSPRT---VKSFPVAAPV--LCIEYIPDPEEE 871

  Fly  2184 YHGHQDSN--PEEGESNQSTMWIGTEDGCIHVYNSTDN----IRIKKN----RIKIEHHSAVYSI 2238
            ..|.::|.  .:...:...|:.:|.:||.|.:|.|.|.    :...|:    .:....||..|
Mouse   872 AEGAEESRAATDPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFY-- 934

  Fly  2239 LYLDNRVFVSLANGDICVYLR-DGATSWNTCS-SHCLSIGTVTSPVNKLLNVNGRLWCSIQGIIK 2301
                  :...|.:|.:..|.| .|...|:..| ..|:::|  ..|:..||::....|.|....:.
Mouse   935 ------LLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVG--PGPIRTLLSLEDAAWASCGPRVT 991

  Fly  2302 VLDVETLTVVNQIQISSD-SKPITNMTVSNNHVWISIQNSAHIKCFHSNTHQLVTEVNLAPAVNK 2365
            |||..||......:...| :..:|:|..:.:.||::..:.:.|:.||:.|.:.:.|:|:|.....
Mouse   992 VLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTF 1056

  Fly  2366 MLSNCDEIIRQHKAACLRVTSLLCCKDLIWIGTSAGVLLTIPAQGYE-------KGAINIVPTGI 2423
            :|..     ::|    |.|||||.|:.|:|:||..||::.:|....|       ||.:::
Mouse  1057 LLPG-----QKH----LCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSL----- 1107

  Fly  2424 PHGHTGHVRFLTF---------------------VETTGLEGAASGAGGGRDAGSSNSDEYTKQ- 2466
             :||.|.|.||..                     .|....:|.|.....|.|  |..:.|.|::
Mouse  1108 -NGHCGPVAFLAVAMSILAPDILRSDQEEAEGPQAEEDKPDGQAHETVPGPD--SHTARELTRKK 1169

  Fly  2467 -----------------------------GSIKHSKS-------------------------KSE 2477
                                         .:::||:.                         :.|
Mouse  1170 GILLQYRLRSTAHLPGPLLSVREPAPADGSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKE 1234

  Fly  2478 TNNTLIISGGDGYEDFRNS--GANSLSEIAGREDSTNHLLIWQI 2519
            ..:..|||||.||..|..:  |.:..:......|||  |||||:
Mouse  1235 ICSVAIISGGQGYRHFGGAPGGLSGRAAPCSETDST--LLIWQV 1276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43102	NP_001247156.1	RhoGEF	1576..1758	CDD:279015	64/181 (35%)
CG43102	NP_001247156.1	PH-like	1750..>1889	CDD:302622	34/190 (18%)
Arhgef10l	NP_001277732.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..94
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..202
		RhoGEF	315..499	CDD:238091	65/184 (35%)
		PH_19	524..679	CDD:408827	36/168 (21%)
		WD40_2	787..1278	CDD:408826	124/563 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1133..1163		6/31 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1186..1207		2/20 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3522
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5001
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840