Protein Alignment CG43102 and arhgef33

DIOPT Version :10

• Sequence 1: NP_001247156.1
• Gene: CG43102 / 42137
• FlyBaseID: FBgn0262562
• Length: 2519
• Species: Drosophila melanogaster
• Sequence 2: XP_687624.3
• Gene: arhgef33 / 559216
• ZFINID: ZDB-GENE-131121-574
• Length: 706
• Species: Danio rerio
• Alignment Length: 692
• Identity: 123/692 - (17%)
• Similarity: 217/692 - (31%)
• Gaps: 240/692 - (34%)

  Fly  1414 VPSHARAASTPSQLEHASKGISAATAQISVSAKNLSQAELDDQVHHMKRAASEAPAPKSNHSKRS 1478
            |...|....|.|:||.........|....:|.:|......:|    :..|.::....:||.....
Zfish    41 VEDFATLRQTYSRLEEKVSSYQQDTNDKILSLRNTLNTLQED----VSTALTQLSEVRSNQKDLQ 101

  Fly  1479 QSMSTERPSQHHHHHGHGHGHSHGH-------------HHAGKRSLDAGSGDKAAKNAPLAGGTS 1530
            :.:...:.:| |.....|.|...||             |:....|
Zfish   102 RDLDLMQSTQ-HRKGSRGEGSVDGHASLNSQTEISLIQHYISSLS-------------------- 145

  Fly  1531 GSGSGGGGKAGLKPTPALLAELLKGSSENMISEQRKKTIADTRTYVVQ------EIYRNEQSYVE 1589
                     |...|.|.     ..|..::.:..:||.:.....:.:.|      |:..:|:.||.
Zfish   146 ---------ANPNPFPE-----HDGQKKSPVWRERKNSRELNNSTITQRQAAALELLESERVYVS 196

  Fly  1590 SLQTVVVKYLKVLKAPEHAGMIDTRTV-DEIFFMVPDILEIHEKFLSDLKSRL--DDWDVQQKVG 1651
            .| ::::|........|:..:.|.|.. ..:.|::...||:    |..|:.|:  ..|  ...:|
Zfish   197 YL-SLLLKANISFNGSENVNLKDKRPFPPSLRFLIQQHLEL----LHLLQERVLKSHW--HGIMG 254

  Fly  1652 DAFMDTFSK-LEVLEVYTSFVNN---CNRAKNAIRSMKHQRPSFSKFLETTAREHKGKLTLDNLL 1712
            |.|:...|| .:.|:.|.|::.:   |....:...|.|.     ...||:.....:.:.||.:||
Zfish   255 DVFLRLTSKESDFLDHYVSYLRDLPECLTVVSLFSSSKS-----GSLLESDMTGDETRPTLYSLL 314

  Fly  1713 IKPVQKFPNYELLFQRLIKHTDHDHPD---------------------TKHLQDVLKLVHDILVH 1756
            ::|||:.|.|..|.|.|::.|:.:|||                     .:|.|::|...|.:..|
Zfish   315 LQPVQRIPEYHTLLQSLLQQTESEHPDYYLLLVSVQQLRSFMTQYNHLLQHNQELLTHSHALREH 379

  Fly  1757 IN--CK--------------------------EREIMENGQREATLR----------------EL 1777
            .:  |.                          |:....:.|.:|:.|                |:
Zfish   380 THNLCTHQQERPSHTRKELSRSTVRQLYKVDYEKNYSSSTQNDASRRNKRYPDYEAAPYHYDPEV 444

  Fly  1778 EGVIEGITDLIAPERQFLLFDLVSMPSGQGARKDRGFFLFNDLLVL------------------T 1824
            ...:..::|..: ..:.:...|.|:|..:||    |..|.:.|..|                  :
Zfish   445 PSPVSFLSDSDS-RHKAISVPLRSIPETEGA----GSVLADALGPLYPYGAGDSRCSSPSHSSDS 504

  Fly  1825 SI---------------------KKRSGTIRKPNSSICPGTVATTLDTNKYKFLTKISLDCLEIV 1868
            ||                     :...|.:.:||.                   |.:|.|..:||
Zfish   505 SIDIAFVRCSPSHSPPRQSHNRGRSAGGVVYRPNR-------------------TCVSPDSADIV 550

  Fly  1869 KSKDENIKRIVSEIETLAEDCNKLQ--QITDITVTIKYPHQYLEDVIRELHREVQRQLSERQTND 1931
            :      .|.:..::..::..|.||  .|..:....|.|          .|..::||.|.:.
Zfish   551 R------PRPLQAVQRKSKSLNGLQMDSIDSLNSQTKNP----------AHPRLERQSSGKS--- 596

  Fly  1932 TQLNMLELTVSSP--------NGNQKLAVVFSKTEKRTQWEE 1965
                  .|..|||        :..::..:...|..:...|||
Zfish   597 ------RLRASSPKHRYETHTDTEEQPRLTHQKDSRSLVWEE 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43102	NP_001247156.1	RhoGEF	1573..1758	CDD:238091	51/218 (23%)
		WD40_2	<2201..>2462	CDD:465964
arhgef33	XP_687624.3	None