Protein Alignment CG43102 and ARHGEF10L

DIOPT Version :9

• Sequence 1: NP_001247156.1
• Gene: CG43102 / 42137
• FlyBaseID: FBgn0262562
• Length: 2519
• Species: Drosophila melanogaster
• Sequence 2: NP_060595.3
• Gene: ARHGEF10L / 55160
• HGNCID: 25540
• Length: 1279
• Species: Homo sapiens
• Alignment Length: 1647
• Identity: 336/1647 - (20%)
• Similarity: 565/1647 - (34%)
• Gaps: 589/1647 - (35%)

  Fly  1084 PPIPHAACKISQTPSTLTTAVRSDLVPTISVSRSSEEGD-----ELAKIEDEPQVEVATTARNTS 1143
            ||.|               |:...|||.:....|..|.|     |....:||.....|....:.:
Human     7 PPQP---------------AIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLA 56

  Fly  1144 MDR-------HIREYSQDDLD-------------LANVDLRSSLEAIATPRHSTDERQRRHLDKS 1188
            .:|       |:......|.|             ::|.|...:  |.:..|||:.:|      ||
Human    57 PERDTDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADA--AFSGARHSSWKR------KS 113

  Fly  1189 TKRKGMYIDNADWQAPTEAPQRGLALDISVANLNAIKPESPEANTPGASQ--MYISSPQSSYSFE 1251
            ::|    ||...:.|..|        |:.   .:.:..|||:|:.|||.:  :|..:.::
Human   114 SRR----IDRFTFPALEE--------DVI---YDDVPCESPDAHQPGAERNLLYEDAHRA----- 158

  Fly  1252 LNTPELEKGSP------SWGSGGLVRDKAQLLSNFSCHSSEEKDDASCRSLSYLRTDSTSDNECD 1310
                    |:|      .|.|           |.|..:|.:..::|.            .:.|.:
Human   159 --------GAPRQAEDLGWSS-----------SEFESYSEDSGEEAK------------PEVEVE 192

  Fly  1311 RAIRERERERITSSPTPSSGDYDYKRFSKRPLRGPYGQMLEAEMKKPNRMHFEEILEELRETDSL 1375
            .|     :.|::..|..|.   |..|..:|..|                          .:.|.|
Human   193 PA-----KHRVSFQPKLSP---DLTRLKERYAR--------------------------TKRDIL 223

  Fly  1376 HLRGSAPGVAAGGTVGPSRNLPQYSNSMRVRKTSTFLPVPSHARAASTPSQLEHASKGISAATAQ 1440
            .||       .||     |::.:..:....:.|                               |
Human   224 ALR-------VGG-----RDMQELKHKYDCKMT-------------------------------Q 245

  Fly  1441 ISVSAKNLSQAELDDQVHHMKRAASEAPAPKSNHSKRSQSMSTERPSQHHHHHGHGHGHSHGHHH 1505
            :..:||:.::..|:.....:.|..|..      |.|.....|.|.
Human   246 LMKAAKSGTKDGLEKTRMAVMRKVSFL------HRKDVLGDSEEE-------------------- 284

  Fly  1506 AGKRSLDAGSGDKAAKNAPLAGGTSGSGSGGGGKAGLKPTPALLAELLKGSSENMISEQRKKTIA 1570
                  |.|..:.:..:                   :||....|..:.:|.|...:
Human   285 ------DMGLLEVSVSD-------------------IKPPAPELGPMPEGLSPQQV--------- 315

  Fly  1571 DTRTYVVQEIYRNEQSYVESLQTVVVKYLKVLKAPEHAGMIDTRTVDEIFFMVPDILEIHEKFLS 1635
             .|.:::..|.::|.||||||:.::..|...|...|... :..|....:||.|.:||..|..|..
Human   316 -VRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKA-LSARKCQVVFFRVKEILHCHSMFQI 378

  Fly  1636 DLKSRLDDWDVQQKVGDAFMDTFSKLEVLEVYTSFVNNCNRAKNAIRSMKHQRPSFSKFLETTAR 1700
            .|.||:.:||..:|:||.|:.:|||..||:||:.:|||...|.:.|:.....:|:|.:||:....
Human   379 ALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQV 443

  Fly  1701 EHKGKLTLDNLLIKPVQKFPNYELLFQRLIKHTDHDHPDTKHLQDVLKLVHDILVHINCKEREIM 1765
            ....::||..|::||:|:||.:.||.|.::|:|...|||...||..|..:..:...:| :::.:.
Human   444 CSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLN-EQKRLA 507

  Fly  1766 ENGQREATLRELEGVIEGITD-------LIAPERQFLLFDLVSM----PSGQGAR-KDRGFFLFN 1818
            :.      :.|::.:.:.::|       |.:.:||.||.:.::.    ..||..: |:|..||.|
Human   508 DQ------VAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLN 566

  Fly  1819 DLLVLTSIKKRSGTIR--KPNSSICP-GTVATTLDTNKYKFLTKISLDCLEIVK--------SKD 1872
            |:||..:|..:....|  ...||:.| |.        ||......:|..:::|:        .||
Human   567 DMLVCANINFKPANHRGQLEISSLVPLGP--------KYVVKWNTALPQVQVVEVGQDGGTYDKD 623

  Fly  1873 ENI-----------------------KRIVSEIETLAEDCNKLQQITDITVTIKYPHQYLE-DVI 1913
            ..:                       .|:..|::.|.:|...::|||.:..|:...:|.|. .|.
Human   624 NVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVA 688

  Fly  1914 RELHREVQRQLSERQTNDTQLNMLELTVSSPNGNQKLAVVFSKTEKRTQWEESFNEAKQKLAATL 1978
            ::....:||.:..::......|...|.:..|          .|.:|
Human   689 QDWCLALQRLMRVKEEEIHSANKCRLRLLLP----------GKPDK------------------- 724

  Fly  1979 ERHPIP---EFLTSIPIRK---------TRAGLQFTCAAATLSDNRDVWVCNSDGYVGQVCIMSL 2031
            ...||.   .|:|..|:.|         .:.||:        .:|:..|:|
Human   725 SGRPISFMVVFITPNPLSKISWVNRLHLAKIGLR--------EENQPGWLC-------------- 767

  Fly  2032 HPEPNVTSCNGVCNARILC---VASVPAYSSAA--------------------SSRNSSSEQ--- 2070
             |:.:..|     .|...|   ...:||:||.|                    |:.::|..|
Human   768 -PDEDKKS-----KAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYL 826

  Fly  2071 -----PAGSGGQEEKDKRHTPQSYTQQLRDYRKSISPSFQSASASATATPEKKKLTPTPTPVAGG 2130
                 ..|:|||.|....:.|                           :|...|..|...||...
Human   827 WVGGGQEGAGGQVEIFSLNRP---------------------------SPRTVKSFPLAAPVLCM 864

  Fly  2131 EPADAATTGGSDTQLELNLSSSDDETEAAAASLNVAGSTGSTLVERVPSPAPSYHGHQDSNPEEG 2195
            |                .:...::|.|:...|..||            .|:.:.|
Human   865 E----------------YIPELEEEAESRDESPTVA------------DPSATVH---------- 891

  Fly  2196 ESNQSTMWIGTEDGCIHVYNSTDNIRIKKNRIKIEHHS-AVYSILYLDNRVF---VSLANGDICV 2256
                .|:.:|.:||.|.:|:|.|.    ..:..:...| .:..:|.|.:..|   ..|.:|.:..
Human   892 ----PTICLGLQDGSILLYSSVDT----GTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAA 948

  Fly  2257 YLR-DGATSWNTCSSH-CLSIGTVTSPVNKLLNVNGRLWCSIQGIIKVLDVETLTVVNQIQISSD 2319
            |.| .|...|:..|.. ||::|  ..||..||::...:|.|....:.||:..||......:...|
Human   949 YPRTSGGVLWDLESPPVCLTVG--PGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQD 1011

  Fly  2320 -SKPITNMTVSNNHVWISIQNSAHIKCFHSNTHQLVTEVNLAPAVNKMLSNCDEIIRQHKAACLR 2383
             :..:|:|..:.:.||::..:...|:.||:.|.:.:.|:|:|.....:|..     ::|    |.
Human  1012 EAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPG-----QKH----LC 1067

  Fly  2384 VTSLLCCKDLIWIGTSAGVLLTIPAQGYE-------KGAINIVPTGIPHGHTGHVRFLTFVETTG 2441
            |||||.|:.|:|:||..||::.:|....|       ||.:::      :||.|.|.||. |.|:.
Human  1068 VTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSL------NGHCGPVAFLA-VATSI 1125

  Fly  2442 L--------EGAASGAGGGRDAGSSNSDE-----------YTKQG-------------------- 2467
            |        :..|.|.....|.....:.|           ..|:|
Human  1126 LAPDILRSDQEEAEGPRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSM 1190

  Fly  2468 ---------SIKHSKS-------------------------KSETNNTLIISGGDGYEDFRNS-G 2497
                     :::||:.                         :.|..:..|||||.||.:|.:: |
Human  1191 REPAPADGAALEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALG 1255

  Fly  2498 ANSLSEIAGREDSTNHLLIWQI 2519
            ::......|..|||  |||||:
Human  1256 SSGRQAPCGETDST--LLIWQV 1275

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43102	NP_001247156.1	RhoGEF	1576..1758	CDD:279015	63/181 (35%)
		PH-like	1750..>1889	CDD:302622	33/184 (18%)
ARHGEF10L	NP_060595.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..91		18/98 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..197		10/65 (15%)
		RhoGEF	317..501	CDD:238091	64/184 (35%)
		WD40 repeat	927..970	CDD:293791	12/42 (29%)
		WD40 repeat	978..1007	CDD:293791	7/28 (25%)
		WD40 repeat	1016..1046	CDD:293791	8/29 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1135..1163		4/27 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1186..1208		2/21 (10%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3522
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D43489at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5001
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850