DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43102 and syd

DIOPT Version :9

Sequence 1:	NP_001247156.1	Gene:	CG43102 / 42137	FlyBaseID:	FBgn0262562	Length:	2519	Species:	Drosophila melanogaster
Sequence 2:	NP_524652.1	Gene:	syd / 43905	FlyBaseID:	FBgn0024187	Length:	1227	Species:	Drosophila melanogaster

Alignment Length:	1260	Identity:	230/1260 - (18%)
Similarity:	444/1260 - (35%)	Gaps:	420/1260 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1551 ELLKGSSENMISE-QRKKTI---ADTRTYVVQEIYRNEQ----SYVESLQTVV-VKYLKVLKAPE 1606
            |||:..:|.:::: :|:|:.   ::.:....:::...|.    :.:||::::| :..||...:.|
  Fly    94 ELLREDNEQLVTQYEREKSARKQSEQKLLEAEDLAEQENKELATRLESVESIVRMLELKHKNSLE 158

  Fly  1607 HAGMIDTRTVDEIFFMVPDILEIHEKFLSDLKSRLDDWD-VQQKVGDAFMDTFSKLEVLEVYTSF 1670
            ||..::.|..|    :..:..::||::....|:.:|..: .:..:|.......:..|.::|..:.
  Fly   159 HASRLEEREAD----LKKEYNKLHERYTELFKNHVDYMERTKMLMGSTHSQMSTASERMDVSRAR 219

  Fly  1671 VNNCNRAKNAI----RSMKHQRPSFSKFLET-------TAREHKGKLTLDNLLIK---PVQKFPN 1721
            :|...|:...:    .|:::     |..|:|       :..:..|..:|.|.|..   .:::...
  Fly   220 LNPVARSSGPVSYGFASLEN-----SVMLDTETICSVGSQSDDSGPPSLQNELDNLSGTLERGAA 279

  Fly  1722 YELLFQRLIKHTDHDHPDTKHLQDVLKLVHDILVHINCKEREIMENGQREATLRELEGVIEGITD 1786
            .:.|.|:       .|..:....|...:|.::..::.           |..|.:|
  Fly   280 TDALQQQ-------HHATSPQSPDSSPVVPNVPTNVG-----------RSTTKKE---------- 316

  Fly  1787 LIAPERQFLLFDLVSMPSGQGARKDRGFFLFNDLLVLTSIKKRSGTIRKPNSSICPGTVATTLDT 1851
                                 .|.|..  |:.:|....:.:.....| ...|.:.||..|::.:.
  Fly   317 ---------------------QRSDNN--LYQELSFQDNEESEENEI-VTGSWVHPGEYASSAND 357

  Fly  1852 NKY---KFLTKISLDCLEIVKSKDE----------NIKRIVSEIETLAEDCNKLQQITDITVTIK 1903
            |.:   |.:..:.::..|::.:|:.          .:..:..|:|.:.|:.|.:||   ....::
  Fly   358 NYFGMGKEVENLIMENNELLATKNALNIVKDDLIVKVDELTGEVEIVREELNAMQQ---SRTKLR 419

  Fly  1904 YPHQYLEDVIRELHREVQRQLSERQTNDTQL-----------------------NMLEL------ 1939
            .....|||.:::...:|::|.:|::.||..|                       .::||
  Fly   420 QRISELEDELKKAKEQVKQQNTEQEENDVPLAQRKRFTRVEMAMVLMERNQYKERLMELQEAVRL 484

  Fly  1940 --------TV---------------------------------------------------SSPN 1945
                    ||                                                   .||:
  Fly   485 TEILRASRTVDNLDRKSKQSIWKYFSNLFTPSNRPTERVADGLGGGPMFRHTGGGSPAHSHGSPS 549

  Fly  1946 -----GNQKLAVVFSK------------------------------TEKRTQ------------- 1962
                 |:.:||:...:                              ..:|.|
  Fly   550 RGSGGGDNRLALTSGQPPVHPASAGLANALIMPKDYAEEGSSERISARRREQYRQLRAHVQKEDG 614

  Fly  1963 ------WEESFNEAKQKLAATLERH----PIPEFLTSIPIRKTRAGLQFTCAA------------ 2005
                  |....|:|.|:  |...||    |:|.:..  |:.:....::..|||
  Fly   615 RLHAYGWSLPINKASQE--ANPNRHSGGVPVPVYCN--PLAEASPHMKVFCAAGVNLHGGFTKNG 675

  Fly  2006 -------------ATL------SDNRD---------------------------VWVCNSDGYVG 2024
                         :||      |...|                           ||:|.|.....
  Fly   676 QSLIPANSPYAPKSTLKIAEITSPTADQSMEALDRQMARVSLETLEPETQLSSFVWICTSTHAAS 740

  Fly  2025 QVCIMSLHPEPNVTSCNGVCNARILCVASVPAYSSAASSRNSSSE--------QPAGSGGQ---- 2077
            .|.::..:....|.....:|.:.:||:|||.....:..:....||        |..|.|.:
  Fly   741 TVSVVDANQSATVLDAFPICASHLLCIASVQGAMESDYALLEQSEVVKAGEMLQRPGEGTELLGK 805

  Fly  2078 --------EEKDKRHTPQSYTQQLRDYRKSISPSFQSASASATATP----EKKKLTPTPTPVAGG 2130
                    :..|::::.:...|:..:.:::...|.:...|.:...|    |..|:. .|.|   |
  Fly   806 VEFVRVKPKSDDEQNSNEKQQQEEEEAKEATEKSNEQLPAVSAEEPLGNVEAIKIR-QPLP---G 866

  Fly  2131 EPADAATTGGSDTQLELNLSSSDDETEAAAASLNVAGSTGSTLVERVPSPAPSYHGHQDSNPEEG 2195
            .|...:|.|....  ..|.|||......|..|||....|...     ..||.|..|
  Fly   867 APQRLSTDGNQTN--NNNNSSSSSNLLFATKSLNPILETKDR-----DEPAMSSVG--------- 915

  Fly  2196 ESNQSTMWIGTEDGCIHVYNSTDNIRIKKNRIKIEHHSAVYSILYLDNRVFVSLANGDICVYLRD 2260
                .|||:|.:||.::|::|........:|:.:.  .||.:|::::.||.|:|||..:.|:.|.
  Fly   916 ----PTMWLGAQDGWLYVHSSVGRWHECLHRVLLP--DAVLAIVHVEARVVVALANAQLAVFRRQ 974

  Fly  2261 GATSWNTCSSHCLSIGTVTSPVNKLLNVNGRLWCSIQGIIKVLDVETLTVVNQIQISSDSKP--- 2322
            ....|:..|.|.:::|.....:..|.....|:|.:.:..|.::|..:|.:|:    |.|:.|
  Fly   975 TDGQWDLNSYHLVTLGDRNHSIRCLCVAGERIWAAHRNKIFIVDPVSLNIVH----SLDAHPRKE 1035

  Fly  2323 --ITNMTVSNNHVWISIQNSAHIKCFHSNTHQLVTEVNLAPAVNKMLSNCDEIIRQHKAACLRVT 2385
              :..|..:...||:||:..:.::.::::|.:...:|::.|.|:|||..     .:...:.:|:|
  Fly  1036 SQVRQMAATGAGVWVSIRLDSTLRLYNTHTFEHKQDVDIEPYVSKMLGT-----GKLGFSFVRIT 1095

  Fly  2386 SLLCCKDLIWIGTSAGVLLTIP-AQGYEKGAINIVPTG-IP-----------HGHTGHVRFLTFV 2437
            :|:...:.:|||||.||::::| |:...|.:.:  |.| :|           |||...|:|  ||
  Fly  1096 ALMVSCNRLWIGTSNGVIISVPLAEVQPKSSSD--PHGQMPLCCMANAQLSFHGHRDAVKF--FV 1156

  Fly  2438 ETTGLEGAASGAGGGRDAGSSNSDEYTKQGSIKHSKSKSETNNTLIISGGDGYEDFR---NSGAN 2499
            ....|:  .....||....:...|                   .|::.||:||.|||   |...|
  Fly  1157 SVPMLQ--QPNLNGGLTFTNKRPD-------------------MLVMCGGEGYIDFRINDNDMEN 1200

  Fly  2500 SL-----SEIAGREDSTNHLLIWQI 2519
            |:     ..|..|.|. ::|::|.:
  Fly  1201 SIQLEPNQTIENRGDK-SYLIVWHV 1224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43102	NP_001247156.1	RhoGEF	1576..1758	CDD:279015	33/201 (16%)
CG43102	NP_001247156.1	PH-like	1750..>1889	CDD:302622	20/151 (13%)
syd	NP_524652.1	Jnk-SapK_ap_N	43..196	CDD:286787	21/105 (20%)
		JIP_LZII	362..430	CDD:293080	12/70 (17%)
		Vps53_N	374..>524	CDD:282020	21/152 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910