DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43102 and PsGEF

DIOPT Version :9

Sequence 1:	NP_001247156.1	Gene:	CG43102 / 42137	FlyBaseID:	FBgn0262562	Length:	2519	Species:	Drosophila melanogaster
Sequence 2:	NP_996333.4	Gene:	PsGEF / 31224	FlyBaseID:	FBgn0264598	Length:	2777	Species:	Drosophila melanogaster

Alignment Length:	1686	Identity:	302/1686 - (17%)
Similarity:	476/1686 - (28%)	Gaps:	669/1686 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PSNENGNSWRSDLRTSSRTPQPIEVDQAVRRRNKSSRLISCCCMRHSTRTVDSEAIQL------- 86
            |.|.|        ||.:.|.....:..:......||:::: ...|..|...:|:..||
  Fly  1489 PKNSN--------RTGTGTGSVTSMSSSTITGELSSKVVA-SSSRRETGDTESDVAQLITDEISQ 1544

  Fly    87 ---------------------EGEAIIGDQQVPHLAPLKLSSSLPT---------------TPQL 115
                                 ||..:|...::.||.|....||||.               .|..
  Fly  1545 SQSEATDDSVGAMPNSSRSAGEGNPVITGSRLRHLDPPVSVSSLPNGHCSAGVGGGSPKPLPPPR 1609

  Fly   116 GQRVVRGRGYKKLSWNEEQPRRQTGE--RSMIARGQEA---RANPPLTYQHLTHNNNNINNNNNN 175
            ..|||       ....:|.||.:..:  ::::...:.|   |::|               ...:.
  Fly  1610 RTRVV-------AQMCQEPPRPKANQQVKAIVTITETARIMRSSP---------------TKGSG 1652

  Fly   176 NNNNNNDGEEYDPIAKYFA--------NTQHQKLSPGIAAKSSRILCENCCGERQQQVGSSMDRQ 232
            :.:....|......|||.|        :..|.:|||.   |.....|:..  |..:|..:::: |
  Fly  1653 SGSATGTGSVGGSPAKYAACHCRCTPEDFTHAQLSPD---KMEHQTCKLL--ESPKQTTTTLE-Q 1711

  Fly   233 KQQPQQ-------------------------------------PHPQQQKRQQQQH--------- 251
            ||:.:|                                     |.|.....:...|
  Fly  1712 KQEDEQLSLMLIGLAQLAPAATLCGQERIPKEENSTPTIAVVPPTPDSVLTKTSTHVWDNSGCSS 1776

  Fly   252 ---------------QQHQQK--QNQQQQQQQQLPFGDYDSVSDLSS----FGFVFDGEEVDSTR 295
                           :|.:|.  :|..:....:.|..:......:||    ||.:...|::.|..
  Fly  1777 NGGGTSTTSTATTTTKQPRQAIIENIPEDSCDESPLDEEPPYRPMSSALRRFGTMSSLEKLPSDD 1841

  Fly   296 RVLVDAHYEDAADDDDDVVRPPVIEIEKRQPN---TSTTKTEKSTEAATVAAAAAATSVGDASSP 357
            |:       |.||:.||       :::..:||   .::.:.|:..|.|....|.....:|.:||.
  Fly  1842 RM-------DEADELDD-------DLDSFKPNGHDGNSPQNEEDDEDADSERALVQNDLGASSSS 1892

  Fly   358 VLSLSSE--------------ISD------ESPAICCYTIDKKLSQQQQQQQQLQQQQQHLQHYN 402
            .:.::.|              :||      ||.|.    |||.|.:
  Fly  1893 GVIVNGEGLASGAWTNRAGAYVSDKMSFFEESRAF----IDKYLGR------------------- 1934

  Fly   403 SCATVSYRSYRHPPPVPPKPRVCVDFSASDEPALKTRRLVCQQQHHHHSHPQPPANPTHFPPRIY 467
                                     ::|.|          .||||.     |..|:.|
  Fly  1935 -------------------------WNAGD----------AQQQHQ-----QGTASET------- 1952

  Fly   468 PANSCCIPKDYQPHAFEGNFSNNINYNCRFGA-SGECTWGSLKGPRSLCYDRHGRLTFDSEPEPE 531
                     |.|..            .|..|| |||..||:   |.|          .....:.:
  Fly  1953 ---------DEQMD------------ECTSGATSGEEVWGT---PTS----------GGDNDDQD 1983

  Fly   532 VVVAKSNGVHKSLSESRLPVQYYAEPKVPYDPYTDLSRVTANVINQNISDRNSSFSLPLQHNRGC 596
            :.:..|...|.|.::|
  Fly  1984 LQLINSENTHSSPTKS------------------------------------------------- 1999

  Fly   597 NALNQVSAASQINNQLTNHIKLNNILLPCHCNFHVDAPYEVNKENGHTMEKRRNTLDRFQRLGFG 661
                    ::.:|:.....:.::.:|:         ||       ..|....|..|.||.|
  Fly  2000 --------STSLNDDDDTELMMDELLM---------AP-------PMTASTIRGLLPRFYR---- 2036

  Fly   662 RKSSPAAAASASTSSSSPSSTSGPEKQRKTSDRSERLRELTELLRGGGGGGSSSRASSTPTPPPP 726
            |:..|.......:........|...|:.:.:.....|.:         ..||||.:.|.|..||.
  Fly  2037 RRLEPLFEEETESDEEKTQQDSDDIKKGEATTNGHYLED---------SAGSSSDSESVPPAPPL 2092

  Fly   727 PPPPVPPPRKPRISHLERQDTGASQTSESEAGSAHLRMPSEETTTRHSGGAGGGGGGVGLSTAAR 791
            .|.||.|.|:...|...:|:..|.:..|....|....:|:                   |:|:|.
  Fly  2093 VPRPVVPDREEDPSAEGQQENLAMEDQEDLHSSVERLLPN-------------------LATSAM 2138

  Fly   792 -----IFASLRPNTSLSNLEAFMLSNREKSKSPPPPAQQNHRPAASRC----------VDASATA 841
                 :...|.|.|::               .|.|||..    .||.|          |.....|
  Fly  2139 GPRPLLTTRLLPTTAI---------------DPQPPAVL----VASSCEYLLDQRPSSVPGRDLA 2184

  Fly   842 SSSASFESTALASRPDSRSAHKAA---------------------PFRSVSFSQIDCKSTLSALR 885
            ..|.. .:|..:|||...|..|||                     |.|:.| |.|   ||:|:..
  Fly  2185 GGSIG-TTTMTSSRPTPLSPAKAAATPIGMNATMTTKTTTTTMMTPSRAPS-STI---STISSAS 2244

  Fly   886 DRLKRDKAIEAPSPSPTHSREEEIAPPDPGWVRIPLKKTELSINLNYGQEKSLDHDAIQEEDIFS 950
            |        ...|......|.....||.|...|:.|.:|:|..    ||.|:         ::..
  Fly  2245 D--------TTSSGGRASGRPPRFVPPPPPPRRLLLTQTDLIA----GQAKT---------ELPR 2288

  Fly   951 NELAASDSSGIVFPVATASSVIAAHATMESLTDTIQSETDCLIKEDVPPPVQPVVEITPPASSV- 1014
            .:..|:..||....|..|:|.               |:...:....:|.        ||..||:
  Fly  2289 KKSGATADSGCSVAVGDAASA---------------SDPTAIGSRTMPS--------TPSTSSLA 2330

  Fly  1015 SGSAPN--LATLMEEQLPLEAP-PDNFLQTATTCEIPVPVYECAAQEWLETP-AQEWVEVAPEEF 1075
            |..||.  .:|::|..| |.|| |.:...:||...:..|:.:....:....| .|......|...
  Fly  2331 SAVAPKRPSSTIIETCL-LGAPRPASATSSATASRMAKPIRQSPPTQHQSQPRGQSCPAAVPAPS 2394

  Fly  1076 GIVPETIQPPIPHAACKISQTPSTLTTAVRSDLVPTISVSRSSEEGDE-LAKIEDEPQVEVATTA 1139
            ...|:....|:|||.|.:|.. ..:..|:..|::           ||| |...|..|.:   ||.
  Fly  2395 TAAPDAPTVPMPHAGCGLSPR-LEMRLALNHDIL-----------GDEDLICYEPGPDL---TTI 2444

  Fly  1140 RNTSMDRHIREYSQDDLDLANVDLRSSLEAIATPRHSTDERQRRHLDKSTKRKGMYIDNADWQAP 1204
            ....:....|...:|.|..:..:.....||:.    |..:::...:|..|..:          .|
  Fly  2445 LGHDLSTFHRLTGRDLLSRSATNRVQPKEAVI----SYSQQRNSKMDTPTVNR----------RP 2495

  Fly  1205 TEAPQRGLALDISVANLNAIKPESPEANTP-------------GASQMYISSPQSSYSFELNTPE 1256
            .......|....|.:|.|..:..|...|:|             |..|:.:.:...|
  Fly  2496 RPLSAGALGGSTSNSNPNNSRSSSSHGNSPLGGGLTRAGVEPVGQQQLVVQAGGGS--------- 2551

  Fly  1257 LEKGSPSWGSGGLVRDKAQLLSNFSCHSSEEKDDASCRSLSYLRTDSTSDNECDRAIRERERERI 1321
              .|....|||....:.....||.......:.:..:.|...|..:.|.|.  |        |.|.
  Fly  2552 --AGRVGGGSGSAGGNSTACSSNRGGSKLGDLEILARREKIYSMSQSRSG--C--------RVRE 2604

  Fly  1322 TSSPTP--------SSGDYDYKRFSKRPLRGPYGQMLEAEMKKPNRMHFEEILEELRETDSLHLR 1378
            |:|.|.        .||....||.|..|.|
  Fly  2605 TTSTTTLMAMATEMRSGMDSEKRDSSWPKR----------------------------------- 2634

  Fly  1379 GSAPGVAAGGTVGPSRNLPQYSNSMRVRKTSTFLPVPSHARAASTPSQLEHA--------SKGI- 1434
                 .||..::..:|:......:..:..|:|           :|.:..|.|        ||.:
  Fly  2635 -----AAAAASLTRTRSSTSMDGAGAISTTTT-----------TTTTMTEEAFLETEVGRSKRLI 2683

  Fly  1435 -------SAATAQISVSAKNLSQAELDDQVHHMKRAASEAPAPKSNHSKRSQSMSTERPSQ 1488
                   |..||..:.|..|.|...:.:|             |:.:||:.|..:....|.|
  Fly  2684 NFIKRRNSEITASSTSSTPNFSDGAIGEQ-------------PQPSHSQSSLLLQKLPPGQ 2731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
CG43102	NP_001247156.1	RhoGEF	1576..1758	CDD:279015
CG43102	NP_001247156.1	PH-like	1750..>1889	CDD:302622
PsGEF	NP_996333.4	DUF4799	<102..209	CDD:292674
		C2	286..>381	CDD:278593
		PDZ_signaling	644..716	CDD:238492
		RhoGEF	831..1000	CDD:295373
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3522
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900