Protein Alignment CG43102 and Arhgef10

DIOPT Version :10

• Sequence 1: NP_001247156.1
• Gene: CG43102 / 42137
• FlyBaseID: FBgn0262562
• Length: 2519
• Species: Drosophila melanogaster
• Sequence 2: XP_017168158.1
• Gene: Arhgef10 / 234094
• MGIID: 2444453
• Length: 1468
• Species: Mus musculus
• Alignment Length: 1701
• Identity: 340/1701 - (19%)
• Similarity: 593/1701 - (34%)
• Gaps: 619/1701 - (36%)

  Fly  1117 SSEEGDELAKIEDEPQVEVATTARNTSMDRHIREYSQDDLDLANVDLRSSLEAIATPRHSTDERQ 1181
            |.|:|:....:..|.:.:..|:  |...:..:.::...| ::...|.:       .|  |.|:|.
Mouse    84 SMEQGEASPPVPAEHEAKCDTS--NNEEEGELFDFDSGD-EVPEADRQ-------VP--SADDRT 136

  Fly  1182 R----RHLDKSTKRKGMYIDNADWQAPT-EAPQRGLALD--------ISVANLNAIKPESPEANT 1233
            |    ...|::|...|    |.....|. ||....|.:.        |.:..|...:|.||:|||
Mouse   137 RGAEAGGADENTCPAG----NGTGAEPAPEAEPAKLVVPTKVNPYSVIDITPLQEDQPSSPDANT 197

  Fly  1234 ---------PGASQMYISSPQSSYSFELNTPELEKGSPSWGSGGLVRDKAQLLSNFSCHSSEEKD 1289
                     |..   |.......|:...|.|.|   .|::.|..::|          ..|.||::
Mouse   198 EEEGVGLRVPSG---YSVPVPCGYAVPSNLPLL---LPAYSSPVIIR----------AESVEEEE 246

  Fly  1290 DASCRSLSYLRTDSTSDNECDRAIRERERERITSSPTPSSGDYDYK------RFSKRPLRGPYGQ 1348
            .|          ::..|.:|:         .::|...|.|.:...:      |::..|..
Mouse   247 AA----------ETVGDGQCN---------SLSSEDLPHSSEQGSQEGSALARWAADPAN----- 287

  Fly  1349 MLEAEMKKPNRMHFEEILEEL--RETDSLHLRGSAPGVAAGGTVGPSRNLPQYSNSMRVRKTSTF 1411
              .|.|:.|....::::..|.  .|.|.:.......|...|      .:.|:|..|     :|.|
Mouse   288 --TAWMENPEEAIYDDVPRENSDSEPDEMIYDDVENGEEGG------NSSPEYGWS-----SSEF 339

  Fly  1412 LP------------VPSHARAASTPSQLEH-----------ASKGISAATAQISVSAKNLSQAE- 1452
            ..            :|.....:|...||.|           ..:|:.|:|    |.|..:.||:
Mouse   340 ESYEEPSDSEGKNGIPRSFLRSSHKKQLSHDLTRFKAHCEEKMRGLVAST----VGAMEIQQAKQ 400

  Fly  1453 -LDDQVHHMKRAASE----------APAPKSNHSKRSQSMSTERPSQHHHHHGHGHGHSHGHHHA 1506
             .:.::..:.:||.|          |...:.....|::|:.::               .|..:..
Mouse   401 RQERKMQKLMKAAKEGTKDGLEKTKAAVKRGGSFIRTRSLVSQ---------------DHRCYFE 450

  Fly  1507 GKRSLDAGSGDKAAKNAPLAGGTSGSGSGGGGKAGLKPTPALLAELLKGSSENMISEQRKKTIAD 1571
            .:::|..   |...|:.               :|.|.|.|       :|.|:..:
Mouse   451 EEQNLFI---DVDCKHP---------------EAVLTPMP-------EGLSQQQV---------- 480

  Fly  1572 TRTYVVQEIYRNEQSYVESLQTVVVKYLKVLKAPEHAGMIDTRTVDEIFFMVPDILEIHEKFLSD 1636
            .|.|::..|..:|::||::|:.::.:|.|.|...| ..::..|.:..:|:.|.:||:.|..|...
Mouse   481 VRRYILGSIVESEKNYVDALRRILEQYEKPLSEME-PRLLSDRKLRMVFYRVKEILQCHSMFQIA 544

  Fly  1637 LKSRLDDWDVQQKVGDAFMDTFSKLEVLEVYTSFVNNCNRAKNAIRSMKHQRPSFSKFLETTARE 1701
            |.||:.:|||.:.:||.|:.:|||..||:.|:.:|||.:.|...::.....:|:|.:||:.:...
Mouse   545 LASRVSEWDVVETIGDVFVASFSKSMVLDAYSEYVNNFSTAVAVLKKTCATKPAFLEFLKLSQDS 609

  Fly  1702 HKGKLTLDNLLIKPVQKFPNYELLFQRLIKHTDHDHPDTKHLQDVLKLVHDILVHINCKEREIME 1766
            ...::||.:|:::|:|:||.:.||.|.::|:|...|||...||..|..:..:...:|  ||
Mouse   610 SPDRVTLHSLMMRPIQRFPQFILLLQDMLKNTAKGHPDRLPLQMALTELETLAEKLN--ER---- 668

  Fly  1767 NGQREATLR-ELEGVIEGITD-----LIAPERQFL-----LFDLVSMPSGQGAR-KDRGFFLFND 1819
              :|:|..| |::.:.:.|.:     |::...::|     :.:.|....|:..: |.|..|:.||
Mouse   669 --KRDADQRCEIKQIAKAINERYLNKLLSSGNRYLVRSDDVIETVYNDRGEIVKTKQRRIFMLND 731

  Fly  1820 LLVLTSIKKRSGTIRKPNSSICPGTVATTLDTNKYKFLTKISLDCLEIVK--------------- 1869
            :|:..:...|       ||.     .:..:.:.:|.....:.|..:::::
Mouse   732 VLMCATASSR-------NSH-----ESHAVMSQRYLLKWSVPLGHVDVIQYNGGSGAGEHCRHHA 784

  Fly  1870 ------------SKDENI----KRIVSEIETLAEDCNKLQQITDITVTIKYPHQYL--------- 1909
                        :|...:    .::..:::.|..|.|.:.||:.:...::..:|.|
Mouse   785 AHSPESLAVVANAKPHKVYMGPGQLYQDLQNLLHDLNVVGQISQLIGNLRGSYQNLNQSVAHDWT 849

  Fly  1910 ----------EDVIRELHR-EVQRQLSERQTNDTQ-------LNML-----ELTVSSPNGNQKLA 1951
                      ||.||...| .:|.||..:|....:       .|.|     |..|||    .::|
Mouse   850 SGLQRLILRKEDAIRAADRCRIQLQLPGKQDKSGRPTFFTAVFNTLTPAIKESWVSS----LQMA 910

  Fly  1952 VVFSKTEKRTQW---EESFNEAKQKLAATLERHPI------------PEFLTSIPIRKTRAGLQF 2001
            .:..:.|....|   ::..|.||:      |.||:            |||             :.
Mouse   911 KLALEEENHMGWFCVDDDGNLAKK------ETHPLLVGHMPVMVAKQPEF-------------KI 956

  Fly  2002 TCAA-------------ATLSDNRD-VWVCNSDGYVGQVCIMSLH-PEPNVTSCNGVCNARILCV 2051
            .|||             |:.|..|. :|:.:....:|||.|:|.. ..|.|..|..| .:||||:
Mouse   957 ECAAYNPEPYLSNESQPASPSTARGFLWIGSCSNQMGQVAIVSFQGSNPKVIECFNV-ESRILCM 1020

  Fly  2052 ASVPAYSSAASSRNSSSEQPAGSGGQEEKDKRHTPQSYTQQLRDYRKSISPSFQSASASATATPE 2116
            ..:||                    :|.|     ||..|:
Mouse  1021 VYIPA--------------------EESK-----PQETTE------------------------- 1035

  Fly  2117 KKKLTPTPTPVAGGEPADAATTGGSDTQLELNLSSSDDETEAAAASLNVAGSTGSTLVERVPSPA 2181
                                              :.|.|..|:.|             ..||
Mouse  1036 ----------------------------------TKDPEATASRA-------------PHVP--- 1050

  Fly  2182 PSYHGHQDSNPEEGESNQSTMWIGTEDGCIHVYNSTDNIRIKKNRIKIEH-----HSAVYSILYL 2241
                               |:.:|||:|.|.:|.|:...:    :::::|     .|.|.|:...
Mouse  1051 -------------------TICLGTEEGSISIYKSSQGCK----KVRLQHFYAPDKSTVMSLACS 1092

  Fly  2242 DNRVFVSLANGD----------------------ICVYLR-----------------DGATSWNT 2267
            ...::..|.||.                      |||:|.                 .|..|||:
Mouse  1093 PQGLYAGLVNGSVASYTKAPAPSSPGSPWAEFCLICVFLPCLPSGAYAISGTGCGAVKGYGSWNS 1157

  Fly  2268 CSSHCLSIGTVTSPVNKLLNVNGRLWCSIQGIIKVLDVETLTVVNQIQISSD-SKPITNMTVSNN 2331
            .....:.:|.:  ||..||.|.|.||.:..|.:.:..|||.|:.||::...| ...|::|.|:..
Mouse  1158 EPQQVIKLGVL--PVRSLLLVEGALWAASGGQVFMASVETHTIENQLEAHQDEGMVISHMAVAGV 1220

  Fly  2332 HVWISIQNSAHIKCFHSNTHQLVTEVNLAPAVNKMLSNCDEIIRQHKAACLRVTSLLCCKDLIWI 2396
            .:||:..:.:.::.||:.|.:.:.:||:...|:.||..       |:.  |.|||||.|..|:.:
Mouse  1221 GIWIAFTSGSTLRLFHTETLKHLQDVNIDAPVHSMLPG-------HQR--LSVTSLLVCHGLLMV 1276

  Fly  2397 GTSAGVLLTIPAQGYEKGAINIVP--TGIP----------HGHTGHVRFLTFVETTGLEGAASGA 2449
            |||.||::.:|           ||  .|||          |.|.|.|:|:  |..|..:......
Mouse  1277 GTSLGVVVALP-----------VPRLQGIPKVTGRGMVSYHAHNGPVKFI--VSATAFQNKDRAR 1328

  Fly  2450 GGGRDAGSSNSDE--------------------YT-------------------KQGS--IKHSK 2473
            ...| :||...||                    ||                   ..||  :.|..
Mouse  1329 DSPR-SGSELQDEDPKDLLCSEEGPSCPGQPDTYTSVWLGDSLGLPTQKNDLSSSSGSLNLSHGS 1392

  Fly  2474 S------------------------------KSETNNTLIISGGDGYEDFRNSGANSLSEIAGRE 2508
            |                              ::..::.|::.||.|:.........     ..:|
Mouse  1393 SSLEHRSVDSSLCDLLRDPSASPRSRPQGSRRARASSALVVCGGQGHRRVHRKARQ-----PSQE 1452

  Fly  2509 DSTNHLLIWQI 2519
            |..:.:::|||
Mouse  1453 DLVSSVMVWQI 1463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43102	NP_001247156.1	RhoGEF	1573..1758	CDD:238091	59/184 (32%)
		WD40_2	<2201..>2462	CDD:465964	83/317 (26%)
Arhgef10	XP_017168158.1	RhoGEF	482..666	CDD:238091	59/184 (32%)
		PH_19	689..838	CDD:465965	21/160 (13%)
		WD40_2	946..1466	CDD:465964	136/685 (20%)