DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43102 and Arhgef17

DIOPT Version :9

Sequence 1:NP_001247156.1 Gene:CG43102 / 42137 FlyBaseID:FBgn0262562 Length:2519 Species:Drosophila melanogaster
Sequence 2:NP_001074585.1 Gene:Arhgef17 / 207212 MGIID:2673002 Length:2057 Species:Mus musculus


Alignment Length:2526 Identity:663/2526 - (26%)
Similarity:986/2526 - (39%) Gaps:711/2526 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   202 SPGIAAKSSRILCENCC---GERQQQVGSSMDRQKQQPQQPHPQQQKRQQQQHQQHQQKQNQQQQ 263
            :||:..::|   |....   |:..::|..........|.||.|.:...                 
Mouse    35 TPGLRRRAS---CRPAAAVPGQPSRRVSKLASGPPAAPAQPRPLRSLS----------------- 79

  Fly   264 QQQQLPFGDYDSVSDLSSFGFVFDGEEVDSTRRVLVDAHYEDAADDDDDVVRPPVIEIEKRQPNT 328
                      .||..||              ||.       |||..|||       ....|....
Mouse    80 ----------PSVRQLS--------------RRF-------DAAGLDDD-------STGTRDGGC 106

  Fly   329 STTKTEKSTEAATVAAAAAATSV----GDASSPVLSLSSE-ISDESPAICCYTIDKKLSQQQQQQ 388
            |:..||::.|.:...|..:.|.:    |..||...|:.|| :...||        .::|.:...:
Mouse   107 SSGTTEEAAEGSERGAWPSVTEMRKLFGGPSSRRPSMDSEALGSTSP--------DRVSWEPPTR 163

  Fly   389 QQLQQQQQHLQHYNSCATVSYRSYRHPPPVPPKPRVCVDFSA------SDEPALKTRRLVCQQQH 447
            ...|                       ||.|| ||.|...:.      ...|.::.||   ::||
Mouse   164 DPRQ-----------------------PPTPP-PRTCFPLAGLRSARPLSGPGIEGRR---RRQH 201

  Fly   448 HHHSHPQPPANPTHFPPRIYPANSCCIPKDYQPHAFEGNFSNNINYNCRFGASGECTWGSLKGPR 512
            ......|.||:..|                                          :|.|...|:
Mouse   202 QQQERAQRPADGLH------------------------------------------SWHSFSQPQ 224

  Fly   513 SLCYDRHGRLTFDSEPEPEVVVAKSNGVHKSLSESRLPVQYYAEPKVPYDPYTDLSRVTANVINQ 577
            :                         |...|.|.|                              
Mouse   225 A-------------------------GARASSSSS------------------------------ 234

  Fly   578 NISDRNSSFSLPLQHNRGCNALNQVSAA--SQINNQLTNHIKLNNILLPCHCNFHVDAPYE-VNK 639
                  .:.|.|:..:|..::..:....  ||:..|           .|.:...|.....| .|.
Mouse   235 ------IASSYPVSRSRAASSSEEEEEGPQSQLGPQ-----------SPAYLGGHSSGSDEDPNG 282

  Fly   640 ENGHTMEKR-----RNTL--------DRFQRLGFGRK---SSPAAAASASTS------SSSPSST 682
            |:|.....|     |:.|        |.....|.|..   .||....|..||      .:.|...
Mouse   283 EDGRRWRGRGLRPGRSQLVHGCSQDSDELNPGGLGSAGGVGSPEPPTSPRTSMDEWGTGTQPCLP 347

  Fly   683 SGPEKQRKTSDRSE---RLRELT--ELLRGGGGGGSSSRASSTPTPPPPPPPPVPPPRKPRISHL 742
            ...|..|..||...   |:.:::  ..|....|...|||.|||.|                   |
Mouse   348 GPQESLRPMSDTGGAPFRVAKVSFPAYLASPAGSRGSSRYSSTET-------------------L 393

  Fly   743 ERQDTGASQTSESEAGSAHLRMPS----------EETTTRHSGGAGGG----GGGVGLSTAARIF 793
            :..|..:|::|   .|....|.||          .:|.:|..|..|..    .||:.|.      
Mouse   394 KDDDLWSSRSS---VGWGVYRSPSFGTGDGLLLRPQTRSRSKGPVGTARPLRDGGLDLD------ 449

  Fly   794 ASLRPNTSLSN---------LEAFMLSNREKSKSPPPPAQQNHRPAASRCVDASATASSSASFES 849
             ..|...||||         |.:|:.|:..:.:...|.....:||...|  |:.:..|.....||
Mouse   450 -KNRQRKSLSNPDIASETLTLLSFLRSDLSELRVRKPSGGPGNRPLDGR--DSPSAGSPMEQSES 511

  Fly   850 TALAS--RPDSRSAHK---AAPFRSVSFSQIDCKSTLSALRDRLKRDKAIEAPSPSPTHSREEEI 909
            |...|  .|.:|...|   |...|:.|||   |..  ..:..||.|..|:: ||.|       |:
Mouse   512 TLSQSPTSPTTRPTLKDLTATLRRAKSFS---CSE--KPMARRLLRTSALK-PSSS-------EL 563

  Fly   910 APPDPGWVRIPLKKTELSINLNYGQEKSLDHDAIQEEDIFSNELAASDSSGIVFPVAT--ASSVI 972
            .....|....||   .|.:...|.||.....:.||...      |..|....|.|.:.  |..:.
Mouse   564 LLAGSGAEEDPL---PLVVQDQYVQEARQVFEKIQRMG------AQQDDGNDVCPTSPDWAGDMT 619

  Fly   973 AAHATMESLTDTIQSETDCLIKEDVPPPVQPVVEITP-----PASSVSGSAPNLATLMEEQLPLE 1032
            ..|.:.|.|:....:.||..|..|..|.......:.|     |.||.|                 
Mouse   620 QGHRSQEELSGPESNLTDEGIGADPEPLGAAFCSLDPAGVWRPLSSTS----------------- 667

  Fly  1033 APPDNFLQTATTCEIPVPVYECAAQEWLETPAQEWVEVAPEEFG----IVPETIQPPIPHAACKI 1093
            |..::.|...|                            .:..|    :.|||  ||.|.|..:.
Mouse   668 AQTNHHLGAGT----------------------------EDSLGGRALVSPET--PPTPGALRRR 702

  Fly  1094 SQTPSTLTTAVRSDLVPTISVSRSSEEGDELAKIEDE-PQVEVATTARNTSMDRHIREYSQDDLD 1157
            .:.|.:         .|..:...:.|..:....:.|. ||...|.|:...|      .:|.|...
Mouse   703 RKVPPS---------GPNGTELSNGEASEAYRSLSDPIPQRHRAATSEEPS------GFSVDSNL 752

  Fly  1158 LANVDLRSSLEAIATPRHSTDERQRRHLDKSTKRKGMYIDNADWQAPTEAPQRGLALDISVAN-- 1220
            |.:::.::.|.  .||  :.||             |:...::||...:|..:....:..|:..  
Mouse   753 LGSLNSKTGLP--VTP--AMDE-------------GLTSGHSDWSVVSEENKDYQEVIQSIVQGP 800

  Fly  1221 --LNAIKPESPEANTPGASQMYISSPQSSYSFELNTPELEKGSPSWGSGG-LVRDKAQLLSNFSC 1282
              |..:..:.....||  .:..:|.|  |...||..|..|      |.|| .:|:...:|...|.
Mouse   801 GALGRMGEDRIAGKTP--KKKSLSDP--SRRGELTGPGFE------GPGGEPIREVEPMLPPSSS 855

  Fly  1283 HS------SEEKDDASCRSLSYLRTDSTSDNECDRAIRERERERITSSPTPSSGDYDY------- 1334
            ..      :|.:|.|..|.               ||..||.   :.:.|..|:..:|:       
Mouse   856 EPILAEQWTEPEDPAPARG---------------RAQSERS---LPAPPASSTAHHDFHLDPKLT 902

  Fly  1335 ----KRFSKRPLRGPYGQMLEAEMKKPNRMHFEEILEELRETDSLHLRGSAPGVAAGGTVGPSRN 1395
                .|.::|           ...|:|.|...:|:..|....|..            |::..:| 
Mouse   903 SVLSPRLTRR-----------GSKKRPARSSHQELRREEGNQDQT------------GSLTQTR- 943

  Fly  1396 LPQYSNSMRVRKTS---TFLP--VPSHARAASTPSQLEHASKGISAATAQISVSAKN---LSQAE 1452
                |:|..||..|   ||.|  ||..|.:...|          .||...:....:.   |....
Mouse   944 ----SSSKHVRHASVPATFTPIVVPEPAMSVGPP----------VAAPEPVGFPVRGHPALQAPS 994

  Fly  1453 LDD--QVHHMKRAASEAPAPKSNHSKRSQSMSTERPSQHHHHHGHGHGHSHGHHHAGKRSLDAGS 1515
            |:|  :.:.:...:.:.|||                                           |.
Mouse   995 LEDVTKRYMLTLHSGDVPAP-------------------------------------------GP 1016

  Fly  1516 GDKAAKNAPLAGGTSGSGSGGGGKAGLKPTPALLAELLKGSSENMISEQRKKTIADTRTYVVQEI 1580
            .|...........|....||.......:|.||              |:...|...|.|.:|...:
Mouse  1017 VDLPCLPPSAPPSTETKPSGAARATPDEPAPA--------------SKCCSKPQVDMRKHVTMTL 1067

  Fly  1581 YRNEQSYVESLQTVVVKYLKVLKAPEHAGMIDTRTVDEIFFMVPDILEIHEKFLSDLKSRLDDWD 1645
            ...||||||||:|::..|::.||.||::.:.|...|||||..:|::||.||:||..::..:..|.
Mouse  1068 LDTEQSYVESLRTLMQGYMQPLKQPENSLLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCVQTWH 1132

  Fly  1646 VQQKVGDAFMDTFSKLEVLEVYTSFVNNCNRAKNAIRSMKHQRPSFSKFLETTAREHKGKLTLDN 1710
            .|||||...:.:|||..::.:|:::::|...||:|:|..|..||:|.||||.:.||:|.|..|.:
Mouse  1133 AQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSD 1197

  Fly  1711 LLIKPVQKFPNYELLFQRLIKHTDHDHPDTKHLQDVLKLVHDILVHINCKEREIMENGQREATLR 1775
            |:|||||:.|.||||.:.|:|||..||||...|.|..:.:..:...||...|...|..:....|:
Mouse  1198 LMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLDAQRNIKQVAERINKGVRSAEEAERHARVLQ 1262

  Fly  1776 ELEGVIEGITDLIAPERQFLLFDLVSMPSGQGARKDRGFFLFNDLLVLTSIKKRSGTIRKPNSSI 1840
            |:|..|||:.||.||.|:||..::|......|.:|||..|||.||:|.|::|::||::|:.:.|:
Mouse  1263 EIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSL 1327

  Fly  1841 CPGTVATTLDT-NKYKFLTKISLDCLEIVK--SKDENIKRIVSEIETLAEDCNKLQQITDITVTI 1902
            .  |.|:.:|| :|||.|.|:.|:..:|:|  |:..|.:.|...|..|.||...|.|::.::.::
Mouse  1328 Y--TAASVIDTASKYKMLWKLPLEDTDIIKGASQATNRETIQKAISRLDEDLATLGQMSKLSESL 1390

  Fly  1903 KYPHQYLEDVIRELHREVQRQLSERQTNDTQL----NMLELTVSSPNGNQKLAVVFSKTEKRTQW 1963
            .:|||.|:|.:|:|...:.|.|||:|.....|    ..|||..:.|.|.......|...:.|..:
Mouse  1391 GFPHQSLDDALRDLSAAMHRDLSEKQALCCSLAFPPTKLELCATRPEGTDSYIFEFPHPDARLGF 1455

  Fly  1964 EESFNEAKQKLAAT---LERHPIPEFLTSIPIRKTRAGLQFTCAAATLSD----NRDVWVCNSDG 2021
            |::|:|||:|||::   |:    ||||.:|||.|||:|:||:|||.|.|.    ..:||||||||
Mouse  1456 EQAFDEAKRKLASSKSCLD----PEFLKAIPIMKTRSGMQFSCAAPTFSSCPEPAPEVWVCNSDG 1516

  Fly  2022 YVGQVCIMSLHPEPNVTSCNGVCNARILCVASVPAYSSAASSRNSSSEQPAGSGGQEEKDKRHTP 2086
            ||||||::||..||:|.:|..||:|||||:.:||                    |.:.:..|..|
Mouse  1517 YVGQVCLLSLRAEPDVEACIAVCSARILCIGAVP--------------------GLQPRCPREQP 1561

  Fly  2087 QSYTQQLRDYRKSISPSFQSASASATATPEKKKLT----PTPTP-----VAGG----EPADAATT 2138
            :..........:|..|..     ...||.|::..|    |.|.|     ::|.    ||..|.  
Mouse  1562 EPLRNPPETTLESTGPEL-----DVEATAEEEAATTLAEPGPQPCLHISISGSGLEMEPGPAK-- 1619

  Fly  2139 GGSDTQLELNL--SSSDDET--------EAAAASLNVAGSTGSTLVERVPS-------------- 2179
              .|.|.||..  |.||||:        ::.|:...::.|.|:   |..||              
Mouse  1620 --GDPQPELVPFDSDSDDESSPSPSGTLQSQASQSTISSSFGN---EETPSSKEATAETTSSEEE 1679

  Fly  2180 PAPSY---------HGHQDSNPEEG------------------------ESNQSTMWIGTEDGCI 2211
            ..|.:         .|...::|.:|                        |:.||::|:||||||:
Mouse  1680 QEPGFLSLSGSFGPGGPCGTSPMDGRALRRSSRGSFTRGSLEDLLSVDPEAYQSSVWLGTEDGCV 1744

  Fly  2212 HVYNSTDNIRIKKNRIKIEHHSAVYSILYLDNRVFVSLANGDICVYLRDGATSWNTCSSHCLSIG 2276
            |||.|:|:||.::|.:|::|.::|..||||:|:||||||||::.||.|:....|:..:...:::|
Mouse  1745 HVYQSSDSIRDRRNSMKLQHAASVTCILYLNNKVFVSLANGELVVYQREAGRFWDPQNFKSMTLG 1809

  Fly  2277 TVTSPVNKLLNVNGRLWCSIQGIIKVLDVETLTVVNQIQISSD-SKPITNMTVSNNHVWISIQNS 2340
            :..||:.|:::|.|||||..|..:.||..:||.:.:...:..| |:.:..|..|:..||::::.|
Mouse  1810 SQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHTFYVGQDSSRSVACMVDSSLGVWVTLKGS 1874

  Fly  2341 AHIKCFHSNTHQLVTEVNLAPAVNKMLSNCDEIIRQHKAACLRVTSLLCCKDLIWIGTSAGVLLT 2405
            ||:..:|.:|.:.:.||::.|.|::||:..|.|||||||||||:|:||.|.:|:|:||||||:||
Mouse  1875 AHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCAELLWVGTSAGVVLT 1939

  Fly  2406 IPAQGYEKGAIN-----IVPTGIPHGHTGHVRFLTFVE-TTGLEGAASGAGGGRDAGSSNSDEYT 2464
            ||.   ....::     :.|.|:..|||||||||..|: ..|.....|......|.|........
Mouse  1940 IPT---SPSTVSCPRAPLSPAGLCQGHTGHVRFLAAVQLPEGFNLLCSTPPPPPDTGPEKLPSLD 2001

  Fly  2465 KQGSIKHSKSKSETNNTLIISGGDGYEDFR-NSGANSLSEIAGREDSTNHLLIWQI 2519
            .:.|.:.....|.....|:||||||.|||| :||....||..||:|||||||:|::
Mouse  2002 HRDSPRRRGPTSARPKMLVISGGDGSEDFRLSSGGGGSSETVGRDDSTNHLLLWRV 2057

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43102NP_001247156.1 RhoGEF 1576..1758 CDD:279015 77/181 (43%)
PH-like 1750..>1889 CDD:302622 52/141 (37%)
Arhgef17NP_001074585.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 20..361 90/532 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 375..461 29/114 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..559 23/85 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 615..647 8/31 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 663..952 77/423 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1054 9/52 (17%)
RhoGEF 1067..1246 CDD:279015 77/178 (43%)
PH-like 1279..>1425 CDD:302622 54/147 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1555..1713 34/169 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1983..2050 24/66 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 477 1.000 Domainoid score I427
eggNOG 1 0.900 - - E1_KOG3522
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006214
OrthoInspector 1 1.000 - - oto94058
orthoMCL 1 0.900 - - OOG6_106017
Panther 1 1.100 - - LDO PTHR12877
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5001
SonicParanoid 1 1.000 - - X5691
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.840

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