DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43102 and osg-1

DIOPT Version :9

Sequence 1:	NP_001247156.1	Gene:	CG43102 / 42137	FlyBaseID:	FBgn0262562	Length:	2519	Species:	Drosophila melanogaster
Sequence 2:	NP_498172.3	Gene:	osg-1 / 175756	WormBaseID:	WBGene00019832	Length:	1182	Species:	Caenorhabditis elegans

Alignment Length:	1447	Identity:	332/1447 - (22%)
Similarity:	588/1447 - (40%)	Gaps:	317/1447 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1118 SEEGDELAKIEDEPQVEVATTARNTSMDRHIRE--YSQDDLDLANVDLRSSLEAIATPRHSTDER 1180
            ::..|..:..:..|.|.|....|:.::....|.  |:......||::.           .:..||
Worm     5 NDADDSDSSTDSSPPVAVPRPKRSATVSPSTRNSFYNSRRRSDANLNF-----------FNERER 58

  Fly  1181 QRRHLDKSTKRKGMYIDNADWQAPTEAPQRGLALDISVANLNAIKPESPEANTPGASQMYISSPQ 1245
            ||.      :|:.|...:.:......|.|:.|....|..|:     :.|..:.....::.:|.|
Worm    59 QRE------RRRSMVRASRERSESRRASQQNLRKTNSEPNV-----DMPSIDVEALQKLLLSIP- 111

  Fly  1246 SSYSFELNTPELEKGSPSWGSGGLVRDKAQLLSNFSCHSSEEKDDASCRSLSYLRTDSTSDNECD 1310
                                                      |..::.|:....|.||.|..|..
Worm   112 ------------------------------------------KFVSASRNRINQRHDSDSGGEMT 134

  Fly  1311 RAIRE--------RERERITSSPTPSSGDYDYKRFSKRPLRGPYGQMLEAEMKKPNRMHFEEILE 1367
            ..|.|        :..:|:.:.|:.:|.|    |...|.|..|....||:.:       |.::.|
Worm   135 TEIEELKDAAKSIQSLQRVLAYPSQTSSD----RGGNRRLADPVESCLESSV-------FSDVDE 188

  Fly  1368 ELRETDSLHLRGSAPGVAAGGTVGPSRNLPQYSNSMRVRKTSTFLPVP-----SHARAASTP--- 1424
            ....||:  :.|...|::.  .:|..|.:.|:..|:|   ...|:|..     |.:|.:|.|
Worm   189 SSLATDT--IEGRRSGIST--RLGHPRGVMQFIPSIR---NDQFVPTSEIRRNSISRKSSVPDGF 246

  Fly  1425 --SQLEHASKGISAATAQISVSAKNLSQAELDDQVHHMKRAASEAPAPKSNHSK-----RSQSMS 1482
              |::|      |.....:....:.:...........:....||..|..:..:|     ||:..|
Worm   247 MTSEME------SEPVPNVRNRRRGIVDEMFSSSTSLLVDRPSETLAGVNRFAKLLDTFRSRPTS 305

  Fly  1483 TERPSQHHHHHGHGHGHSHGHHHAGKRSLDAGSGDKAAKNAPLAGGTSGSGSGGGGKAGLKPTPA 1547
               |.||.....:.:.:|.|    |:.....|..|...:
Worm   306 ---PEQHPSISWNPYVYSDG----GEALETCGMEDSLHE-------------------------- 337

  Fly  1548 LLAELLKGSSENMISEQRKKTIADTRTYVVQEIYRNEQSYVESLQTVVVKYLKVLKAPEHAGMID 1612
              |::|.....:..|.:|..::   |....:|:...|:|:||.|:.:|.||::.|:.|....:|:
Worm   338 --ADILLWKKRSRASLRRHYSV---RHLAARELLDTEKSFVEGLEFLVTKYMRPLRQPLECTLIE 397

  Fly  1613 TRTVDEIFFMVPDILEIHEKFLSDLKSRLDDWDVQQKVGDAFMDTFSKLEVLEVYTSFVNNCNRA 1677
            ...||:||:.:|:||..|:..|:.|..|:|.|.....:||..:..|||..::|.|.|||:|...|
Worm   398 ASLVDKIFYRIPEILAHHQVLLTTLSQRIDQWHKDAILGDVLLAHFSKQSMIETYISFVDNFKFA 462

  Fly  1678 KNAIRSMKHQRPSFSKFLETTAREHKGKLTLDNLLIKPVQKFPNYELLFQRLIKHTDHDHPDTKH 1742
            |.:|...: |:.:|.|:.....|:|..||.||:|||.|:|:.|.|||:.::::|||..:|.|.:.
Worm   463 KASIIQAR-QKHAFEKYYNRCCRDHPNKLDLDSLLISPIQRVPRYELIVKQMLKHTPVEHEDRER 526

  Fly  1743 LQDVLKLVHDILVHINCKEREIMENGQREATLRELEGVIEGITDLIAPERQFLLFDLVSMPSGQG 1807
            |....:.:|.:.|.|| :.::..|  |.|..|||:|.:::|:.||:..:|..|..|::::   :|
Worm   527 LLRAQRHIHCLAVAIN-QHKDGSE--QMEQRLREIEAIVDGLDDLVTKDRTLLRHDIITL---KG 585

  Fly  1808 ARKDRGFFLFNDLLVLTSIKKRSGTIRKPNSSICPGTVATTLDTNKYKFLTKISLDCLEIVKSKD 1872
            ..::|..|:.:|||::||:||:...:....||...|    .|:.|::|.|.|::|:.::|.|...
Worm   586 TDRERCIFMLSDLLLVTSVKKKPKVLYSKMSSQSMG----FLEGNRFKLLFKVALEDVQISKDTL 646

  Fly  1873 ENIKRIVSEIETLAEDCNKLQQITDITVTIKYPHQYLEDVIRELHREVQ---RQLSERQTNDTQL 1934
            ..::.:..::|:..||...|::::.:...:|...:.|.:::..:.....   |:|:|:.::|..|
Worm   647 SQLEEVERKLESSREDDRVLKKMSQLCSLLKCERKVLMEMLETMETSNSMSIRELNEQMSSDPDL 711

  Fly  1935 NMLELTVSSPNGNQKLAVVFSKTEKRTQWEESFNEAKQKLAATLERHPIPEFLTSIPIRKTRAGL 1999
            :.:.|.|.:.||.:...:.|...|||:.:|..|.:||..||..|...|... |.:|...:||.||
Worm   712 SAVHLDVLTSNGFEPFVLEFPNAEKRSVFEAMFKDAKATLAKNLLAAPSCS-LKTIIAHQTRPGL 775

  Fly  2000 QFTCAAATLSDNR-----DVWVCNSDGYVGQVCIMSLHP-EPNVTSCNGVCNARILCVASVPAYS 2058
            |. |.|..:...|     .:|||.||.:.|||.:|:|.. |..:.||:.:.||.:..:.:||
Worm   776 QL-CTATVVPGKRVDSTPSLWVCASDKFSGQVAVMALDTGEITIESCSAIGNAAVTAMCTVP--- 836

  Fly  2059 SAASSRNSSSEQPAGSGGQEEKDKRHTPQSYTQQLRDYRKSISPSFQSASASATATPEKKKLTPT 2123
                       .|.....::.|.::.......:.:.|...|
Worm   837 -----------PPMKLRKRKIKSQKSLEHLLNETIMDINSS------------------------ 866

  Fly  2124 PTPVAGGEPADAATTGGSDTQLELNLSSSDDETEAAAASLNVAGSTGSTLVERVPSPAPSYHGHQ 2188
                            ||||:     ||||:.|..|
Worm   867 ----------------GSDTE-----SSSDEGTSTA----------------------------- 881

  Fly  2189 DSNPEEGESNQSTMWIGTEDGCIHVYNSTDNIRIKKNRIKIEHHSAVYSILYLDNRVFV--SLAN 2251
                     .|:|:|||.:||.:.|.|||:.:|.:.........:::.||...:..|.|  |.:|
Worm   882 ---------GQTTVWIGNDDGEVFVVNSTERVRSRARDRLARLRNSITSICAANGNVLVATSYSN 937

  Fly  2252 GDICVYLR---DGATSWNTCSSHCLSIGTV-TSPVNKLLNVNGRLWCSIQGIIKVLDVETLTVVN 2312
            ....:..|   ||  ||:.  .:..::|.| .:|:..:..:..|:..:....:....|:|.....
Worm   938 QVQLLLFRPASDG--SWDL--ENPQTVGHVCQAPITSMQLIGRRVIIASGNWLHAYFVDTGKFQP 998

  Fly  2313 QIQISSDSKPITNMTVSNNHVWISIQNSAHIKCFHSNTHQLVTEVNLAPAVNKMLSNCDEIIRQH 2377
            .::|...|..||.|.|:..:|::..:.|..:.........::...|:...|...||..:.|:|:|
Worm   999 PVEILPSSDVITLMYVTGQNVFLCGRKSTEVFVVDVFNLSIINHFNVVSFVRSQLSGREHILREH 1063

  Fly  2378 KAACLRVTSLLCCKDLIWIGTSAGVLLTIPAQGYEKGAINIVPTGIPH------GHTGHVRFLTF 2436
            |..|||::.|...:..:|||||||.:|:...|     :....||  |.      ||:|..|.|..
Worm  1064 KMGCLRISCLTVARSHLWIGTSAGCVLSTSVQ-----SARSQPT--PDLRVCEIGHSGPCRILLP 1121

  Fly  2437 VETTGLEGAASGAGGGRDAGSSNSDEYTKQGSIKHSKSKSETNNTLIISGGDGYEDFRNSGANSL 2501
            |.|              .:.|::.....|:.|:  :....:::..:::|.|:|.:|...:...|
Worm  1122 VHT--------------PSHSNHPSRKQKRSSL--NVPAQQSSQLMLVSCGEGLDDGTATQDPS- 1169

  Fly  2502 SEIAGREDSTNHLLIWQ 2518
                  .|:.|||:.|:
Worm  1170 ------TDAINHLIFWK 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43102	NP_001247156.1	RhoGEF	1576..1758	CDD:279015	65/181 (36%)
CG43102	NP_001247156.1	PH-like	1750..>1889	CDD:302622	40/138 (29%)
osg-1	NP_498172.3	RhoGEF	361..543	CDD:214619	67/183 (37%)
osg-1	NP_498172.3	PH-like	524..>612	CDD:302622	28/93 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I1438
eggNOG	1	0.900	-	-		E1_KOG3522
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D43489at33208
OrthoFinder	1	1.000	-	-		FOG0006214
OrthoInspector	1	1.000	-	-		oto17329
orthoMCL	1	0.900	-	-		OOG6_106017
Panther	1	1.100	-	-	LDO	PTHR12877
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5001
SonicParanoid	1	1.000	-	-		X5691
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.850