DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43102 and arhgef10

DIOPT Version :9

Sequence 1:NP_001247156.1 Gene:CG43102 / 42137 FlyBaseID:FBgn0262562 Length:2519 Species:Drosophila melanogaster
Sequence 2:XP_002935203.3 Gene:arhgef10 / 100490713 XenbaseID:XB-GENE-877296 Length:1376 Species:Xenopus tropicalis


Alignment Length:1845 Identity:359/1845 - (19%)
Similarity:619/1845 - (33%) Gaps:714/1845 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   907 EEIAPPDPGWVRIPLKKTELSINLNYGQEKSLDHDAIQEEDIFS-NELAASDSSGIVFPVATASS 970
            |:..||.|     .:...||::| ....||..|.||.::.|..| :|:..:|...:..|      
 Frog    10 EDFPPPPP-----EVYVDELTLN-GPAYEKDDDEDAGEKFDFDSGDEIPEADRQPLEVP------ 62

  Fly   971 VIAAHATMESLTDTIQSETDCLIKEDVPPPVQPVVEITPPASSVSGSAPNLATLMEEQLPLEAPP 1035
                              .|.||.:....|..||:             ||..|  :::||.|.. 
 Frog    63 ------------------GDTLIDQGFQFPDPPVL-------------PNEIT--KQELPTETS- 93

  Fly  1036 DNFLQTATTCEIPVPVYECAAQEWLETPAQEWVEVAPEEFGIVPETIQPPIPHAACKISQTPSTL 1100
               .:.||....|..:.:.|       |.||......|:.....|:..|.:|..    ...|...
 Frog    94 ---TKMATKKVNPYSIIDIA-------PFQEVDSATSEDLVSTDESTSPRVPSG----YSVPVPC 144

  Fly  1101 TTAVRSDLVPTISVSRSSEEGDELAKIEDEPQVEVATTA--RNTSMDRHIREYSQDDLDLANVDL 1163
            ..||.|:| |.:..:.|:........|:::...||....  ..||.|.|:......|.:|::.|.
 Frog   145 GYAVPSNL-PLLQPAYSTPVIIRNISIDEQGVQEVVPNPHFHFTSEDDHLSRPIGRDGELSSEDF 208

  Fly  1164 RSSLEA------IATPRHSTDERQRRHLDKSTKRKGMYIDNADWQAPTEAPQRGLALDISVANLN 1222
            :|:.|.      :|.|.                       |.:|.   |.|...:..|:      
 Frog   209 QSTREEDVLAKWVANPA-----------------------NTEWM---ENPDEVIYDDV------ 241

  Fly  1223 AIKPESPEANTPGASQMYISSPQSSYSFELNTPELEKGSPSWGSGGLVRDKAQLLSNFSCHSSEE 1287
                  |..|:..|     :.|:     |:...::|.|... |:..|         ::...|||.
 Frog   242 ------PRENSDSA-----TDPE-----EMIYDDVENGEDG-GNSSL---------DYGWSSSEF 280

  Fly  1288 KDDASCRSLSYLRTDSTSDNECDRAIRERERERITSSPTPSSGDYDYKRFSKRPLRGPYGQMLEA 1352
            :        ||   :..||:|....:             |:|.           |||        
 Frog   281 E--------SY---EEHSDSESKHGV-------------PNSF-----------LRG-------- 302

  Fly  1353 EMKKPNRMHFEEILEELRETDSLHLRGSAPGVAAGGTVGPSRNLPQYSNSMRVRKTSTFLPVPSH 1417
                .|:.|..:.|..|::                          .|...|:             
 Frog   303 ----NNKRHLSQDLTRLKQ--------------------------HYEKKMK------------- 324

  Fly  1418 ARAASTPSQLEHASKGISAATAQISVSAKNLSQAELDDQVHHMKRAASEAPAPKSNHSKRSQSMS 1482
                                    .:.|..:...|    :.|.|                     
 Frog   325 ------------------------DLVANRVGAVE----IQHFK--------------------- 340

  Fly  1483 TERPSQHHHHHGHGHGHSHGHHHAGKRSLDAGSGDKAAKNAPLAGGTSGSGSGGGGKAGLKPTPA 1547
                              |.|....:|.:      ||||.              |.|.||:.|.|
 Frog   341 ------------------HKHELKMQRLV------KAAKE--------------GTKDGLEKTKA 367

  Fly  1548 LLAELLKGSS----ENMISEQRKKTIAD-------------------------------TRTYVV 1577
            .:.   ||.|    ::.:...||.|..:                               .|.|::
 Frog   368 AVK---KGRSYIRTKSFVLHDRKSTSLEDDELNLFIDVDCMHIEAIMSPMPEGLSQQQVVRRYIL 429

  Fly  1578 QEIYRNEQSYVESLQTVVVKYLKVLKAPEHAGMIDTRTVDEIFFMVPDILEIHEKFLSDLKSRLD 1642
            ..|..:|::||:||:.::.:|.|.|...| ..::..|.:..:|:.:.:||:.|..|...|.||:.
 Frog   430 GSIVESEKNYVDSLKRILEQYEKPLWETE-PRLLSERKLKIVFYRIKEILQCHSLFQIALASRVA 493

  Fly  1643 DWDVQQKVGDAFMDTFSKLEVLEVYTSFVNNCNRAKNAIRSMKHQRPSFSKFLETTAREHKGKLT 1707
            :||..:.:||.|:.:|||..||:.|:.:|||.:.|...:|.....:|||.:||:........::|
 Frog   494 EWDTAEMIGDVFVASFSKSMVLDAYSEYVNNFSTAVGVLRKACATKPSFLEFLKQCQESSPDRIT 558

  Fly  1708 LDNLLIKPVQKFPNYELLFQRLIKHTDHDHPDTKHLQDVLKLVHDILVHINCKERE--------- 1763
            |..|::||:|:||.:.||.|.::|:|:..|||...||..|..:..:...:|.::|:         
 Frog   559 LYGLMMKPIQRFPQFILLLQDMLKNTNKGHPDRLPLQMALTELETLADKLNERKRDADQRCEIKQ 623

  Fly  1764 ------------IMENGQREATLRELEGVIEGITDLIAPERQFLLFDLVSMPSGQGARKDRGFFL 1816
                        ::.||.|  .|...:.::|.:.:    ||..::           ..|.|..|:
 Frog   624 IAKAMNERYLNKLLSNGSR--YLVRSDDMVETVFN----ERGEII-----------KTKQRRLFM 671

  Fly  1817 FNDLLVLTSIKKRSGTIRKPNSSICPGTVATTLDTNKYKFLTKISL-----DCLEIVKSKDENIK 1876
            .||:|:..:...||..         .|:.|.|  ||: |:|.|.|:     :.:|..:|:|:..:
 Frog   672 LNDVLMCATANARSSV---------EGSSAVT--TNQ-KYLLKWSVPLSHAEVIEYGESEDQGDQ 724

  Fly  1877 RIVS--------------------------EIETLAEDCNKLQQITDITVTIKYPHQYL------ 1909
            .:.|                          :::.|..|.:.:.||:.:...:|..:|.|      
 Frog   725 TLYSSLHVAEKVVVSSKPNKLYMGPGQLYNDLQNLLHDLDVVNQISQLVGQLKGNYQNLNHAVAQ 789

  Fly  1910 -------------EDVIRELHR-EVQRQLSERQTND---TQLNMLELTVS-----SPNGNQKLAV 1952
                         |:.||...| .:|.||..:|...   |....:..|.|     |...|.::|.
 Frog   790 DWSVGLQKLILKKENEIRAADRCRIQLQLPGKQDKSGRPTYFTAVFNTFSPAAKQSWLSNLQMAK 854

  Fly  1953 VFSKTEKRTQW---EESFNEAKQKLAATLERHPIPEFLTSIP-IRKTRAGLQFTCAAAT----LS 2009
            :....|..|.|   |:..::.|:      |:||:  .:..:| :...:...:..||...    ||
 Frog   855 LALGEENNTGWFCLEDEGHQVKK------EKHPL--LVKHLPVVMSKQQEFKIECAVYNPEPYLS 911

  Fly  2010 DNRD----------VWVCNSDGYVGQVCIMSLH-PEPNVTSCNGVCNARILCVASVPAYSSAASS 2063
            ...|          :|:.:....:||:.::||| ..|.|..|..| .:||||:..:|        
 Frog   912 SENDPDTLSMHHGFLWIGSCTNQMGQISVLSLHNRSPKVLECFNV-ESRILCMVYIP-------- 967

  Fly  2064 RNSSSEQPAGSGGQEEKDKRHTPQSYTQQLRDYRKSISPSFQSASASATATPEKKKLTPTPTPVA 2128
                         :|.|.|         ||.|     :|..::                      
 Frog   968 -------------EEAKQK---------QLSD-----APDLEN---------------------- 983

  Fly  2129 GGEPADAATTGGSDTQLELNLSSSDDETEAAAASLNVAGSTGSTLVERVPSPAPSYHGHQDSNPE 2193
                                                     ||:.|..||               
 Frog   984 -----------------------------------------GSSRVPDVP--------------- 992

  Fly  2194 EGESNQSTMWIGTEDGCIHVYNSTDNIRIKKNRIKIEH-----HSAVYSILYLDNRVFVSLANGD 2253
                   |:.:|.|:|.|.||.|:..    ..:::::|     .|.|.|:..:...::..|.||:
 Frog   993 -------TICLGMEEGSICVYKSSQG----SKKVRLQHFFTPEKSTVMSLASISQCLYAGLVNGN 1046

  Fly  2254 ICVYLRDGATSWNTCSSHCLSIGTVTSPVNKLLNVNGRLWCSIQGIIKVLDVETLTVVNQIQI-S 2317
            :..|.:....:|||.....:.:|.:  ||..||.:...:|.:....|.::..::..:.:|.:. |
 Frog  1047 LATYTKAEDGNWNTDQPKLIKLGVL--PVRSLLIMERTIWAASGEQIFIIGQDSNAIEHQFEAHS 1109

  Fly  2318 SDSKPITNMTVSNNHVWISIQNSAHIKCFHSNTHQLVTEVNLAPAVNKMLSNCDEIIRQHKAACL 2382
            .:...|::|.|:...:||:....:.::.||:.|.:.:.::|:|..::.||..      ||:.:  
 Frog  1110 EEGMVISHMAVAGVGIWIAFTTGSTLRLFHTETFEHLQDINIATPIHNMLPG------QHRVS-- 1166

  Fly  2383 RVTSLLCCKDLIWIGTSAGVLLTIPA---QGYEK----GAINIVPTGIPHGHTGHVRFLTFVETT 2440
             |||||.|..|:.:||:.||::::|.   ||..|    |.::.      |.|...|:||  |:.|
 Frog  1167 -VTSLLVCHGLLMVGTNLGVIVSLPVPRLQGIPKVTGRGMVSY------HAHHSPVKFL--VKAT 1222

  Fly  2441 GL---------------------------------EGAASGA----------GGGRDAGSSNSDE 2462
            .:                                 |.|||..          ||...:.:..||.
 Frog  1223 AINKKYRRTPSRCSQISHSELKNEDSHCTGVQQNDEAAASATNNNNDSAVWLGGSMGSIAQKSDL 1287

  Fly  2463 YTKQGSI--------------------------------KHSKSKS-ETNNTLIISGGDGYEDFR 2494
            .:..||:                                |..|:|. :.::.|:||||.|:... 
 Frog  1288 SSSSGSLTLSHGSNSCDAGKEDCTLSDLLGDPSMPLPNSKQQKAKRLKADSVLVISGGQGHRKL- 1351

  Fly  2495 NSGANSLSEIAGREDSTNHLLIWQI 2519
                |...:...:|:..:..::|||
 Frog  1352 ----NKKVKPQRQEELVSSAMVWQI 1372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43102NP_001247156.1 RhoGEF 1576..1758 CDD:279015 59/181 (33%)
PH-like 1750..>1889 CDD:302622 31/190 (16%)
arhgef10XP_002935203.3 RhoGEF 425..609 CDD:238091 61/184 (33%)
PH_19 632..781 CDD:408827 33/177 (19%)
WD40_2 889..1374 CDD:408826 121/633 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D43489at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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