DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43102 and arhgef10l

DIOPT Version :9

Sequence 1:	NP_001247156.1	Gene:	CG43102 / 42137	FlyBaseID:	FBgn0262562	Length:	2519	Species:	Drosophila melanogaster
Sequence 2:	XP_031760704.1	Gene:	arhgef10l / 100158460	XenbaseID:	XB-GENE-996306	Length:	1354	Species:	Xenopus tropicalis

Alignment Length:	1540	Identity:	324/1540 - (21%)
Similarity:	538/1540 - (34%)	Gaps:	464/1540 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1224 IKPESP--EANTP---GASQMYISSPQSSYSFELNTPELEKGSPSWGSGGLVRDKAQLLSNFSCH 1283
            ::|:.|  :.|.|   |:::..:.|.:|| .|..:|  :|..||..               ..|.
Frog    31 LEPKHPRHQFNQPSQKGSARRDMDSAESS-RFHFHT--VEDVSPKL---------------IGCS 77

  Fly  1284 SSEEKDDASCRSLSYLRTDSTSDNECDRAIRERERERITSSPTPSSGDYDYKRFSKRPLRGPYGQ 1348
            ..|:.||....:..:   ||..:.|....|.:.|.:..|||
Frog    78 QQEDDDDDQGEAFDF---DSEGEEEDSGTIPKAEVQLRTSS------------------------ 115

  Fly  1349 MLEAEMKKPNRMHFEEILEELR-ETDS---LHLRGSAPGVAAGGTVGPSRNLPQYSNSMR---VR 1406
               ..:::|...|..|..|.|: :|::   :.|..|:..|:.|..|| .:.|..|:.|::   |:
Frog   116 ---ISIERPPLAHTGEGTENLQNKTEAAAPVSLSRSSSSVSNGDPVG-RKKLEIYTCSLKRSSVK 176

  Fly  1407 KTST---------------FLPVPSHARAASTPSQLEHASKGISAATAQISVSAKNLSQAELDDQ 1456
            :.|:               :..||...............:.|.|..|...||   .|....:.:.
Frog   177 RDSSSEKVCGPRGTQDGAIYEDVPCEQENQDGKEPARTPTLGASTVTPCASV---GLGYHLIYEN 238

  Fly  1457 VHHMKRAASEAPAPKSNHSKRSQSMSTERPSQHHHHH--------------GHGHGHSHGHHHAG 1507
            |||............|:....|.|..:|...:.....              ..........:...
Frog   239 VHHEGSERDLEDTGWSSSEFESYSEDSEEEEEEERRKIKPAKPFVAFQPKLSPDLSRLKERYSRT 303

  Fly  1508 KRSLDA----GSGD---------------KAAKNAPLAG---------------------GTSGS 1532
            ||.|.|    |||.               |||::....|                     |.|..
Frog   304 KRDLLALRGRGSGAQELKHTYNWKMTQLMKAARSGTKDGLEKTRIAVMRKVTFLQRKETTGDSEE 368

  Fly  1533 GSGG-----GGKAGLKPTPALLAELLKGSSENMISEQRKKTIADTRTYVVQEIYRNEQSYVESLQ 1592
            ...|     |....|||.|:.|..:.:|.|...:          .|.:::..|.::|:|||||||
Frog   369 EESGFFEVIGLDLDLKPPPSELGPMPEGLSAQQV----------LRRHILASIVQSERSYVESLQ 423

  Fly  1593 TVVVKYLKVLKAPEHAGMIDTRTVDEIFFMVPDILEIHEKFLSDLKSRLDDWDVQQKVGDAFMDT 1657
            .|:..|...|...| ..::.||....:|..|.:||..|..|...|.||:.:|||.:||||.|:.:
Frog   424 RVLQDYRNPLMDME-PKLLSTRKCQMVFSRVKEILHCHSVFQIALSSRVAEWDVSEKVGDLFVAS 487

  Fly  1658 FSKLEVLEVYTSFVNNCNRAKNAIRSMKHQRPSFSKFLETTAREHKGKLTLDNLLIKPVQKFPNY 1722
            |||..||:||:.:|||...|...|:.....:|:|..||.........::||..|::||:|:||.:
Frog   488 FSKSIVLDVYSEYVNNFTNAMTVIKKACLTKPAFLDFLRKKQAASPDRVTLYGLMVKPIQRFPQF 552

  Fly  1723 ELLFQRLIKHTDHDHPDTKHLQDVLKLVHDILVHINCKEREIMENGQREATLRELEGVIEGITD- 1786
            .||.|.::|:|...|||...||..|..:..:...:| :::.:.:.      :.|::.:.:.|:|
Frog   553 ILLLQDMLKNTPCGHPDRLSLQLALTELETLAEKLN-EQKRVADQ------MAEIQQLCKSISDR 610

  Fly  1787 ------LIAPERQFLLFD-LVSMPSGQGAR----KDRGFFLFNDLLVLTSIKKRSGT-------- 1832
                  |.:.:.|.||.: |..|..|...:    |:|..||.||:||..:|..:...
Frog   611 SSLYKSLSSGQHQLLLCETLTEMVYGDKGQLLKSKERRLFLMNDVLVCANINFKGQPDIGNLVPL 675

  Fly  1833 ----IRKPNSSICP------GTVATTLDTN----------KYKFLT----KISLDCLEIVKSKDE 1873
                :.|.|:.:..      |......:.:          |:.|.:    |:||
Frog   676 GPRYVLKWNTPLAQIYVAELGQEGNAFEKDLAAGQQGVGRKHSFSSQLQNKVSL----------- 729

  Fly  1874 NIKRIVSEIETLAEDCNKLQQITDITVTIKYPHQYLEDVIRE-----LHREVQRQLSERQTNDTQ 1933
            ...|:..|::.:..|...::|||.:..|:...:|.|...:.:     |.|.|:.:..|.|:
Frog   730 GSPRLFQELQDVKRDLEVVEQITQLISTLHGTYQNLNMTVAQDWCLGLQRLVRLKEEEIQS---- 790

  Fly  1934 LNMLELTVSSPNGNQK------LAVVFSKTE--KRTQWEESFNEAKQKLAATLERHPIPEFLTSI 1990
            .|...|.:..|....|      ..|||....  .:..|....:.||                  |
Frog   791 ANKCHLQLQLPRKADKSGRPMSFMVVFITPNPLSKISWVNRLHLAK------------------I 837

  Fly  1991 PIRKTRAGLQFTCAAATLSDNRDVWVCNSDGYVGQVCIMSLHPEPNVTSCNGVCNARILCVASVP 2055
            .:|:               :|:..|:|               ||..........:..::|  .:|
Frog   838 ALRE---------------ENQPGWLC---------------PEEEKKVKAPFWSPTLVC--RLP 870

  Fly  2056 AYSSAASSRNSSSEQPAGSGGQEEKDKRHTPQSYTQQLRDYRKSISPSFQSASASATATPEKKKL 2120
            |:|:.|:...        .||..     |||             :..|....|:.:|:.|:....
Frog   871 AFSTKAADLQ--------LGGAV-----HTP-------------VQNSLLGFSSVSTSLPQGYLW 909

  Fly  2121 TPTPTPVAGGEPADAATTGGSDTQLELNLSSSDDETEAAAASLNVAGSTGSTLVERVPSP----- 2180
                  |.||:      .||:.              .....|||   .|...:::..|.|
Frog   910 ------VGGGQ------VGGAG--------------HIQIFSLN---HTSPRMLKAFPLPSCVLC 945

  Fly  2181 -------APSYHGHQDSNPEEGESNQSTMWIGTEDGCIHVYNSTDN-----IRIKK---NRIKIE 2230
                   ||..:..:|.......|.:..:.:|.:||.|.||.:.|.     :.:..   ..:|..
Frog   946 VENVCPRAPEGNDERDEEESAAGSARPAVCVGLQDGSIMVYGNVDTGTPCLMAVGSPGVQPVKCL 1010

  Fly  2231 HHSAVYSILYLDNRVFVSLANGDICVYLRDGATSWNTCSSHCLSIGTVTSPVNKLLNVNGRLWCS 2295
            .||..:        :...|.:|.:.:|.......|:..|...:.:|  ..||..||.::|.:|.|
Frog  1011 RHSPSF--------LCAGLQDGSVALYPATQGGLWDPGSPLVVKVG--DGPVQALLVIDGCVWAS 1065

  Fly  2296 IQGIIKVLDVETLTVVNQIQISSDSKPITNMTVSNNHVWISIQNSAHIKCFHSNTHQLVTEVNLA 2360
            .:..:.||:..||.......:..:...||:|..|...||::....:.|:.||:.|.:|:.|:|:|
Frog  1066 CRNRVTVLEPGTLKTQTFEAVQDEGISITHMVRSGGGVWMAFSGGSSIRLFHTETLELLQEINIA 1130

  Fly  2361 PAVNKMLSNCDEIIRQHKAACLRVTSLLCCKDLIWIGTSAGVLLTIPAQGYE-------KGAINI 2418
            .....:....:.          |:|:||.|:.|:|:||..|:|:|:|....|       ||.:::
Frog  1131 TRTMLLPGQKNP----------RITALLICQGLLWVGTDLGILVTLPVPKLEGIPKITGKGMVSL 1185

  Fly  2419 VPTGIPHGHTGHVRFLTFV-ETTGLEGAASGAGGGRDAGSSNSDEYTKQ---------------- 2466
                  :||.|.|:|||.. .:...:...:..|.|.|...|:.....|:
Frog  1186 ------NGHCGPVQFLTLACSSIAPDELRTDQGSGEDISQSDGPAEPKEDTPDGPDLPSDNAPPS 1244

  Fly  2467 -----------------------------------------GSI----------------KHSKS 2474
                                                     |||                ....:
Frog  1245 RLKGILLQYRLRGTSHLPGLHLSAREGSRTDSCTPATSEEDGSIYEMADEPDVWCRSRPCSKDAN 1309

  Fly  2475 KSETNNTLIISGGDGYEDFRNSGANSLSEIAGREDSTNHLLIWQI 2519
            :.|..:.:|:|||.|:..|..|..  .|:..|..|||  ||:||:
Frog  1310 RKEITSVVIVSGGAGHRTFHPSPC--ASQPGGDTDST--LLMWQL 1350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43102	NP_001247156.1	RhoGEF	1576..1758	CDD:279015	67/181 (37%)
CG43102	NP_001247156.1	PH-like	1750..>1889	CDD:302622	30/182 (16%)
arhgef10l	XP_031760704.1	RhoGEF	404..588	CDD:238091	68/184 (37%)
		PH_19	613..763	CDD:408827	31/160 (19%)
		WD40_2	871..1354	CDD:408826	116/565 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D43489at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010