DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43102 and si:ch211-248g20.5

DIOPT Version :9

Sequence 1:	NP_001247156.1	Gene:	CG43102 / 42137	FlyBaseID:	FBgn0262562	Length:	2519	Species:	Drosophila melanogaster
Sequence 2:	XP_003200462.1	Gene:	si:ch211-248g20.5 / 100002227	ZFINID:	ZDB-GENE-091204-478	Length:	1035	Species:	Danio rerio

Alignment Length:	1074	Identity:	402/1074 - (37%)
Similarity:	612/1074 - (56%)	Gaps:	142/1074 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1528 GTSGSGSGGG----------------GKAGLKPTPALLAELLKGSSENMISEQRKKTIADTRTYV 1576
            |.|.|..|||                |..|....|..:||                   |.|.:|
Zfish    22 GESISDDGGGVGEEVERSVTAEPNGNGIVGNTGAPQTIAE-------------------DMRRHV 67

  Fly  1577 VQEIYRNEQSYVESLQTVVVKYLKVLKAPEHAGMIDTRTVDEIFFMVPDILEIHEKFLSDLKSRL 1641
            :..:...||||||||:|::..|:|.||.||:..:.|...|||:|:.:|:|||.||:||..:...:
Zfish    68 MMNLLDAEQSYVESLRTLIQGYMKPLKHPENPPLCDPSLVDEMFYQIPEILEHHEQFLEQVLDCV 132

  Fly  1642 DDWDVQQKVGDAFMDTFSKLEVLEVYTSFVNNCNRAKNAIRSMKHQRPSFSKFLETTAREHKGKL 1706
            ..|..:|.:|...:.:|||..:..:|:::::|...||:|:|..|..:|:|.||||.:.||::.|.
Zfish   133 HQWHDKQTIGHVLIQSFSKETLANIYSAYIDNFMNAKDAVRIAKEAKPAFLKFLEQSMRENREKQ 197

  Fly  1707 TLDNLLIKPVQKFPNYELLFQRLIKHTDHDHPDTKHLQDVLKLVHDILVHINCKEREIMENGQRE 1771
            .|.:|:|||||:.|.||||.:.|:|||..||||...|.|..|.:..:...|| |.|...|..:||
Zfish   198 ALGDLMIKPVQRIPRYELLVKDLLKHTPEDHPDYLFLLDAQKNIKRLAERIN-KGRRSAEELERE 261

  Fly  1772 A-TLRELEGVIEGITDLIAPERQFLLFDLVSMPSGQGARKDRGFFLFNDLLVLTSIKKRSGTIRK 1835
            . .::|:|..|||:..::.|:|:||..::|......|.:|||..|||:|||:.|::|::||::|:
Zfish   262 TRVMQEIEAHIEGVEHILNPQRKFLRQEMVVEAKTVGGKKDRSLFLFSDLLICTTLKRKSGSLRR 326

  Fly  1836 PNSSICPGTVATTLDT-NKYKFLTKISLDCLEIVKSKD-----ENIKRIVSEIETLAEDCNKLQQ 1894
            .:.|:.  :.|:.:|| :|||||.|:.|:.:|:||..:     ||:::.:|.::   ||.:.|.|
Zfish   327 SSMSLY--SAASVIDTSSKYKFLWKLPLEDIEVVKGSNQATNRENVQKTISRLD---EDLSTLGQ 386

  Fly  1895 ITDITVTIKYPHQYLEDVIRELHREVQRQLSERQTNDTQLNML--ELTVSSPNGNQKLAVVFSKT 1957
            ::.::.|:.:|||.|:|||::|...|.|:|:|:|:....:.:|  :|.:|..:........||..
Zfish   387 VSKLSETLSFPHQSLDDVIKDLMASVHRELAEKQSLAFSMTLLPTKLELSCTSAESSFIFEFSSP 451

  Fly  1958 EKRTQWEESFNEAKQKLAATLERHPIPEFLTSIPIRKTRAGLQFTCAAATLS---DNRDVWVCNS 2019
            :.|:.:|::|.|||:|||...::.. ||||.:|||.|||:|:||:||:.:.|   :..:||||||
Zfish   452 DTRSNFEQAFEEAKKKLAMNKDQWD-PEFLKAIPIMKTRSGMQFSCASPSHSCPENTYEVWVCNS 515

  Fly  2020 DGYVGQVCIMSLHPEPNVTSCNGVCNARILCVASVPAYS----------SAASSRNSS------- 2067
            ||||||||::::..||.|.:|..||:|||:|:|:||...          :|.|..||:
Zfish   516 DGYVGQVCLLNIRDEPTVEACIAVCSARIICIATVPGLKNRERVVHSTPTAPSDSNSAATTQPQL 580

  Fly  2068 -----------SEQPAGSGGQ------EEKDKRHTPQ-SYTQQLRDYRKSISPSFQS-----ASA 2109
                       ||.||....:      ::.|...:|. |.|.|.:....:||.||.:     |..
Zfish   581 HICISGSSLELSEPPAVPTAELVPFDSDDTDDEDSPSPSSTLQSQASHSTISSSFGNDEAVVAKD 645

  Fly  2110 SATATPEKKKLTPTPTPVAGGEPADAATTGGSDTQLELNLSSSDDETEAAAASLNVAGSTGSTLV 2174
            .||.|...::....|.|.:.|.|.                .|::...:..|...:..||.....:
Zfish   646 MATETTSSEEEQEFPVPSSFGAPR----------------LSAESPMDGRAMRRSSRGSFTRASL 694

  Fly  2175 ERVPSPAPSYHGHQDSNPEEGESNQSTMWIGTEDGCIHVYNSTDNIRIKKNRIKIEHHSAVYSIL 2239
            |.:.|..|             |:.||::|:||||||||||.|:||||.:||.:|::|.::|..||
Zfish   695 EDLLSIDP-------------EAYQSSVWLGTEDGCIHVYQSSDNIRNRKNSMKMQHSASVLCIL 746

  Fly  2240 YLDNRVFVSLANGDICVYLRDGATSWNTCSSHCLSIGTVTSPVNKLLNVNGRLWCSIQGIIKVLD 2304
            ||||:||||||||::.||.|:..:.|:..||..|.:|:.:.||.|::.|.|:|||..|..|.:::
Zfish   747 YLDNKVFVSLANGEVIVYQREAGSFWDPQSSQTLCLGSPSGPVTKMVPVAGKLWCGCQNRILIIN 811

  Fly  2305 VETLTVVNQIQISSDS-KPITNMTVSNNHVWISIQNSAHIKCFHSNTHQLVTEVNLAPAVNKMLS 2368
            ..|||..:..|:..|| :.:|:|......|||::|.||.::.:||:|::.:|||::||||:|||:
Zfish   812 TSTLTQEHWFQVGQDSGRCVTSMVCFGKGVWIALQGSAQVRLYHSSTYESLTEVDVAPAVHKMLA 876

  Fly  2369 NCDEIIRQHKAACLRVTSLLCCKDLIWIGTSAGVLLT--IPAQGYEKGA----INIVPTGIPHGH 2427
            ..|.|||||||||||:|:||.||||:||||||||:||  :|......|:    :.::|.|..|||
Zfish   877 GSDAIIRQHKAACLRITALLACKDLLWIGTSAGVVLTLVVPPVSSSTGSGSLRVPLIPMGSAHGH 941

  Fly  2428 TGHVRFLTFVETTGLEGAASGAGGGRDAGSSNSDEYTKQGSIKHSKSKSET-------NNTLIIS 2485
            ||||||||.:|..  ||.........::.|.||.:....|..:...::...       :|.|:||
Zfish   942 TGHVRFLTCIELP--EGFDVSFPPPAESASQNSSDSGTGGLQRRDSARRRASTLLPTKSNLLVIS 1004

  Fly  2486 GGDGYEDFRNSGANSLSEIAGREDSTNHLLIWQI 2519
            |||||||||.:.:   ||..||:|||||||:|::
Zfish  1005 GGDGYEDFRLTNS---SETVGRDDSTNHLLLWRV 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43102	NP_001247156.1	RhoGEF	1576..1758	CDD:279015	74/181 (41%)
CG43102	NP_001247156.1	PH-like	1750..>1889	CDD:302622	50/145 (34%)
si:ch211-248g20.5	XP_003200462.1	RhoGEF	67..250	CDD:279015	76/183 (42%)
si:ch211-248g20.5	XP_003200462.1	PH-like	283..467	CDD:302622	65/188 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D43489at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010