Protein Alignment TyrR and TAAR2

DIOPT Version :10

• Sequence 1: NP_650652.1
• Gene: TyrR / 42136
• FlyBaseID: FBgn0038542
• Length: 631
• Species: Drosophila melanogaster
• Sequence 2: NP_001028252.1
• Gene: TAAR2 / 9287
• HGNCID: 4514
• Length: 351
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 100/528 - (18%)
• Similarity: 157/528 - (29%)
• Gaps: 262/528 - (49%)

  Fly   117 IILIAVFATFIVVTVIGNTLVILAILTTRRLRTITNCFVMSLAVADLLVGIFVMPPAVAVHLIGS 181
            :.:.:..|..|.:|:.||..:|::|...::|.|.||..::|:|:.|.|:|..:||.::...:...
Human    44 VAMYSFMAGSIFITIFGNLAMIISISYFKQLHTPTNFLILSMAITDFLLGFTIMPYSMIRSVENC 108

  Fly   182 WQLGWVLCDIWISLDVLLCTASILSLCAISVDRYLAVTRPLTYSRKRR---SKRLALIMILIVW- 242
            |..|...|.|:.|.|::|...||..||::::||:.|:..||.||.|..   .|||    :|:.|
Human   109 WYFGLTFCKIYYSFDLMLSITSIFHLCSVAIDRFYAICYPLLYSTKITIPVIKRL----LLLCWS 169

  Fly   243 ------------------------LLALAITCPPMLGWYEPGRRDLRECRYNQNEGYVIFSAMGS 283
                                    |:|.:.:||.|               :|:..|..:|  |..
Human   170 VPGAFAFGVVFSEAYADGIEGYDILVACSSSCPVM---------------FNKLWGTTLF--MAG 217

  Fly   284 FFIPMAVMIYVYARISCVIASRHDNMTDISVHNKKFKRYTAADVENELSEQEQHSSVGQRQRQAT 348
            ||.|.::|:.:|.:|..|
Human   218 FFTPGSMMVGIYGKIFAV----------------------------------------------- 235

  Fly   349 SRTFSNQTIAKELQDMMLSDSDNCAAMGAGGAGGGGGGASSATGGTHCQSLLALPSGGVGGSMGC 413
                                                                             
Human   236 ----------------------------------------------------------------- 235

  Fly   414 AKNGCYELTRPSSLKRASTASTTITTMTSGMGPGSSLLDAQWQSQPPGQTGQVQTHSLSQPPRTH 478
                                                                             
Human   236 ----------------------------------------------------------------- 235

  Fly   479 SFRHSHGERDRERLRSHHHHPHYHHQAGVTTTSTSGNTSANTNSKSLSNRITSLKKENKTTQTLS 543
            |.:|:|                           ...|...|.|::        :||:.|..:||.
Human   236 SRKHAH---------------------------AINNLRENQNNQ--------VKKDKKAAKTLG 265

  Fly   544 IVVGGFIACWLPFFINYLITPFLAEHQASQMLAKALTWLGWFNSAINPFIYAFYSVDFRAAFWRL 608
            ||:|.|:.||.|.|...|:.||| ......:|..||||.|:|||..||.||.|:...||.|...:
Human   266 IVIGVFLLCWFPCFFTILLDPFL-NFSTPVVLFDALTWFGYFNSTCNPLIYGFFYPWFRRALKYI 329

  Fly   609 TCKRFFSA 616
            ...:.||:
Human   330 LLGKIFSS 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrR	NP_650652.1	7tmA_tyramine_R-like	118..>304	CDD:320189	58/213 (27%)
		TM helix 1	118..144	CDD:320189	7/25 (28%)
		TM helix 2	151..177	CDD:320189	9/25 (36%)
		TM helix 3	189..219	CDD:320189	12/29 (41%)
		TM helix 4	232..255	CDD:320189	9/47 (19%)
		TM helix 5	272..297	CDD:320189	8/24 (33%)
		7tm_GPCRs	<533..605	CDD:475119	33/71 (46%)
		TM helix 6	539..561	CDD:320189	10/21 (48%)
		TM helix 7	573..598	CDD:320189	14/24 (58%)
TAAR2	NP_001028252.1	7tmA_TAAR2_3_4	44..326	CDD:320437	97/515 (19%)
		TM helix 1	45..71	CDD:320437	7/25 (28%)
		TM helix 2	78..104	CDD:320437	9/25 (36%)
		TM helix 3	116..146	CDD:320437	12/29 (41%)
		TM helix 4	158..181	CDD:320437	5/26 (19%)
		TM helix 5	206..235	CDD:320437	10/30 (33%)
		TM helix 6	255..285	CDD:320437	14/29 (48%)
		TM helix 7	294..319	CDD:320437	14/24 (58%)